Inhibition of insulin metabolism by hydroxychloroquine and its enantiomers in cytosolic fraction of liver homogenates from healthy and diabetic rats

scientific article published on January 1999

Inhibition of insulin metabolism by hydroxychloroquine and its enantiomers in cytosolic fraction of liver homogenates from healthy and diabetic rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0024-3205(98)00568-2
P698PubMed publication ID10072192

P2093author name stringPasutto FM
Mercer JR
Jamali F
Emami J
P2860cites workInsulin degradation by human skeletal muscleQ71468888
Purification and Characterization of a Protease with Specificity for Insulin from Rat MuscleQ71778363
A randomized trial of hydroxychloroquine in early rheumatoid arthritis: the HERA StudyQ72524724
Insulin degradation: mechanisms, products, and significanceQ28289497
Effect of chloroquine on insulin and glucose homoeostasis in normal subjects and patients with non-insulin-dependent diabetes mellitusQ34068803
A dose-ranging study of the pharmacokinetics of hydroxy-chloroquine following intravenous administration to healthy volunteersQ34417966
Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiographyQ37038758
The potential role of lysosomes in tissue distribution of weak basesQ39563115
Insulin metabolism and degradationQ40318035
Clinical pharmacokinetics of slow-acting antirheumatic drugsQ40619935
Accelerated Insulin Degradation: An Alternate Mechanism for Insulin ResistanceQ41030978
Enantioselective disposition of hydroxychloroquine after a single oral dose of the racemate to healthy subjectsQ41898692
In vitro binding of chloroquine to rat muscle preparationsQ41914838
Receptor-mediated 125I-labelled insulin degradation in the rat hepatocyte. Studies using chloroquineQ41920673
Chloroquine stimulation of insulin binding to IM-9 lymphocytes: evidence for action at a nonlysosomal siteQ41924095
Hydroxychloroquine compared with placebo in rheumatoid arthritis. A randomized controlled trialQ41936586
Hydroxychloroquine in decompensated, treatment-refractory noninsulin-dependent diabetes mellitus. A new job for an old drug?Q41943988
Hepatic processing of insulin. Characterization of differential inhibition by weak basesQ41945927
Degradation of insulin and proinsulin by various organ homogenates of rat.Q48718867
Insulin degradation I. Purification and properties of glutathione-insulin transhydrogenase of rat liverQ54231139
Analytical and semi-preparative high-performance liquid chromatographic separation and assay of hydroxychloroquine enantiomersQ67578604
Effect of receptor up-regulation on insulin pharmacokinetics in streptozotocin-treated diabetic ratsQ67936320
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectenantiomerQ494483
hydroxychloroquineQ421094
P304page(s)325-335
P577publication date1999-01-01
P1433published inLife SciencesQ5256275
P1476titleInhibition of insulin metabolism by hydroxychloroquine and its enantiomers in cytosolic fraction of liver homogenates from healthy and diabetic rats
P478volume64

Reverse relations

cites work (P2860)
Q34389286A favorable effect of hydroxychloroquine on glucose and lipid metabolism beyond its anti-inflammatory role
Q91828431COVID-19 and diabetes: Knowledge in progress
Q88917533Cardiovascular Safety of Biologics and JAK Inhibitors in Patients with Rheumatoid Arthritis
Q34354276Changes in glycosylated hemoglobin after initiation of hydroxychloroquine or methotrexate treatment in diabetes patients with rheumatic diseases
Q35013063Does atorvastatin work more effectively than biguanides in reducing cardiovascular risk factors?
Q33819280Effect of atorvastatin and hydroxychloroquine combination on blood glucose in alloxan-induced diabetic rats
Q35519392Hydroxychloroquine as a glucose lowering drug
Q88400696Hydroxychloroquine-induced hypoglycaemia in non-diabetic renal patient on peritoneal dialysis
Q37827403Hydroxychloroquine: from malaria to autoimmunity
Q94680079Parallel epidemics, or nearly so: certainties and uncertainties about sars-cov-2 in italy
Q52316454Protective Effects of Hydroxychloroquine against Accelerated Atherosclerosis in Systemic Lupus Erythematosus.
Q35607534Stereoselectivity in the pharmacodynamics and pharmacokinetics of the chiral antimalarial drugs.
Q41917902The effectiveness of hydroxychloroquine in patients with type 2 diabetes mellitus who are refractory to sulfonylureas--a randomized trial
Q38561490Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases
Q41942164Vascular elasticity of systemic lupus erythematosus patients is associated with steroids and hydroxychloroquine treatment

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