Geldanamycin-mediated inhibition of heat shock protein 90 partially activates dendritic cells, but interferes with their full maturation, accompanied by impaired upregulation of RelB.

scientific article published on 13 February 2014

Geldanamycin-mediated inhibition of heat shock protein 90 partially activates dendritic cells, but interferes with their full maturation, accompanied by impaired upregulation of RelB. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1042770763
P356DOI10.1186/1756-9966-33-16
P932PMC publication ID3926270
P698PubMed publication ID24524692
P5875ResearchGate publication ID260194349

P2093author name stringMatthias Bros
Angelika B Reske-Kunz
Stefanie Trojandt
P2860cites workAn interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machineQ21134999
I kappa B: a specific inhibitor of the NF-kappa B transcription factorQ24296774
A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1betaQ24300765
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformationQ24564127
Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancersQ27022514
Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancerQ28264693
The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cellsQ28268683
NF-kappaB and the immune responseQ28271031
Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathwaysQ28585900
Expression of relB is required for the development of thymic medulla and dendritic cellsQ28594949
Characteristics of a human cell line transformed by DNA from human adenovirus type 5Q29547863
HSP90 at the hub of protein homeostasis: emerging mechanistic insightsQ29616824
HSP90 and the chaperoning of cancerQ29617504
Taking dendritic cells into medicineQ29619243
Cancer immunotherapy comes of ageQ29619918
A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-alpha, and contact sensitizersQ32133166
Th1/Th2 balance in cancer, transplantation and pregnancyQ33833226
Differential expression of Rel/NF-kappaB and octamer factors is a hallmark of the generation and maturation of dendritic cellsQ33884442
Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyteQ33935976
Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cellsQ35239937
Prostaglandin E2 induces matrix metalloproteinase 9 expression in dendritic cells through two independent signaling pathways leading to activator protein 1 (AP-1) activationQ35604210
Exploiting dendritic cells for cancer immunotherapy: genetic modification of dendritic cellsQ35910661
Turning NF-kappaB and IRFs on and off in DC.Q37183815
Targeting Hsp90: small-molecule inhibitors and their clinical developmentQ37222845
Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cellsQ37286051
A phase II study of 17-allylamino-17-demethoxygeldanamycin in metastatic or locally advanced, unresectable breast cancerQ37338986
HSP90 as a platform for the assembly of more effective cancer chemotherapyQ37973573
The network interaction of the human cytosolic 90 kDa heat shock protein Hsp90: A target for cancer therapeutics.Q37975002
HSP90 inhibition: two-pronged exploitation of cancer dependenciesQ37975881
The specialized roles of immature and mature dendritic cells in antigen cross-presentationQ37997315
Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequentialQ39549098
HSP90 modulates actin dynamics: Inhibition of HSP90 leads to decreased cell motility and impairs invasionQ39649592
Blocking NF-κB and Akt by Hsp90 inhibition sensitizes Smac mimetic compound 3-induced extrinsic apoptosis pathway and results in synergistic cancer cell deathQ39652497
Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70.Q39715278
Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradation.Q40120827
Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IkappaB kinase (IKK).Q40211366
The Hsp90-specific inhibitor geldanamycin selectively disrupts kinase-mediated signaling events of T-lymphocyte activationQ40425004
Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharideQ40431320
The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanismsQ42808605
Role of c-Jun N-terminal kinase on lipopolysaccharide induced maturation of human monocyte-derived dendritic cellsQ45101254
Identification of prostaglandin E2 receptor subtype 2 as a receptor activated by OxPAPC.Q46079127
Differential activation of NF-kappa B subunits in dendritic cells in response to Gram-negative bacteria and to lipopolysaccharide.Q50115551
A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma.Q51549127
Characterization of a human ovarian adenocarcinoma line, IGROV1, in tissue culture and in nude miceQ69842539
Fascin is involved in the antigen presentation activity of mature dendritic cellsQ73311874
Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinasesQ73520518
Comparison of allergen-stimulated dendritic cells from atopic and nonatopic donors dissecting their effect on autologous naive and memory T helper cells of such donorsQ73784782
Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditionsQ74179201
Expression of the actin-bundling protein fascin in cultured human dendritic cells correlates with dendritic morphology and cell differentiationQ74347120
Dendritic cell maturation requires STAT1 and is under feedback regulation by suppressors of cytokine signalingQ75424784
Immune modulation and tolerance induction by RelB-silenced dendritic cells through RNA interferenceQ80178345
Phenotypic and functional effects of heat shock protein 90 inhibition on dendritic cellQ80427928
Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapyQ81343360
Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory responseQ82252356
P304page(s)16
P577publication date2014-02-13
P1433published inJournal of Experimental & Clinical Cancer ResearchQ13739415
P1476titleGeldanamycin-mediated inhibition of heat shock protein 90 partially activates dendritic cells, but interferes with their full maturation, accompanied by impaired upregulation of RelB.
P478volume33

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cites work (P2860)
Q40120736Addition of 17-(allylamino)-17-demethoxygeldanamycin to a suboptimal caspofungin treatment regimen in neutropenic rats with invasive pulmonary aspergillosis delays the time to death but does not enhance the overall therapeutic efficacy
Q55467257BRAF inhibitors stimulate inflammasome activation and interleukin 1 beta production in dendritic cells.
Q36358976HSP90 Inhibitor Geldanamycin as a Radiation Response Modificator in Human Blood Cells
Q58729712Immunogenic Effect of Hyperthermia on Enhancing Radiotherapeutic Efficacy

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