Blocking NF-κB and Akt by Hsp90 inhibition sensitizes Smac mimetic compound 3-induced extrinsic apoptosis pathway and results in synergistic cancer cell death

scientific article published on January 2011

Blocking NF-κB and Akt by Hsp90 inhibition sensitizes Smac mimetic compound 3-induced extrinsic apoptosis pathway and results in synergistic cancer cell death is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10495-010-0542-4
P932PMC publication ID3079540
P698PubMed publication ID20862547
P5875ResearchGate publication ID46404578

P2093author name stringHong Tang
Xia Wang
Yong Lin
Zi Li
Lang Bai
Wenshu Chen
Shanling Xu
P2860cites workThe Hallmarks of CancerQ221226
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosisQ24300707
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosisQ24300734
TNF-alpha induces two distinct caspase-8 activation pathwaysQ24313656
Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosisQ24609324
Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activationQ28140363
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitinationQ28284721
Shared principles in NF-kappaB signalingQ29547234
Nuclear factor-kappaB in cancer development and progressionQ29547879
NF-kappaB: linking inflammation and immunity to cancer development and progressionQ29614597
Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosisQ33714703
Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expressionQ33978041
DNA damage-induced apoptosisQ34312499
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteinsQ34377284
The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapyQ34596902
TRAF2 exerts its antiapoptotic effect by regulating the expression of Krüppel-like factor LKLFQ35169970
Nuclear factor-kappaB: the enemy withinQ35893620
Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an updateQ36066038
Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugsQ36085634
The Akt/PKB pathway: molecular target for cancer drug discoveryQ36313193
Heat shock protein 90: the cancer chaperoneQ36834685
Akt-dependent and -independent mechanisms of mTOR regulation in cancerQ37114404
Drug discovery approaches targeting the PI3K/Akt pathway in cancerQ37270455
Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cellsQ37273453
Targeting the PI3K/AKT pathway for the treatment of prostate cancerQ37564760
Akt is a downstream target of NF-kappa B.Q38288465
Concurrent blockade of the NF-kappaB and Akt pathways potently sensitizes cancer cells to chemotherapeutic-induced cytotoxicityQ39731546
Attenuating Smac mimetic compound 3-induced NF-kappaB activation by luteolin leads to synergistic cytotoxicity in cancer cellsQ39801796
IKKbeta-mediated nuclear factor-kappaB activation attenuates smac mimetic-induced apoptosis in cancer cellsQ39840485
Blockage of NF-kappaB by IKKbeta- or RelA-siRNA rather than the NF-kappaB super-suppressor IkappaBalpha mutant potentiates adriamycin-induced cytotoxicity in lung cancer cellsQ39959876
Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cellsQ40123984
Sensitization of TNF-induced cytotoxicity in lung cancer cells by concurrent suppression of the NF-kappaB and Akt pathwaysQ40168027
A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cellsQ40171730
The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activationQ40263696
Phase I pharmacokinetic-pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancersQ40425901
17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathwayQ46902088
Association of constitutive nuclear factor-kappaB activation with aggressive aspects and poor prognosis in cervical cancer.Q53303723
Potential biomarkers involving IKK/RelA signal in early stage non-small cell lung cancerQ80539024
P433issue1
P921main subjectNF-κBQ411114
P304page(s)45-54
P577publication date2011-01-01
P1433published inApoptosisQ15749546
P1476titleBlocking NF-κB and Akt by Hsp90 inhibition sensitizes Smac mimetic compound 3-induced extrinsic apoptosis pathway and results in synergistic cancer cell death
P478volume16

Reverse relations

cites work (P2860)
Q35549167A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis
Q33861908Abrus agglutinin suppresses human hepatocellular carcinoma in vitro and in vivo by inducing caspase-mediated cell death.
Q41959409Geldanamycin-mediated inhibition of heat shock protein 90 partially activates dendritic cells, but interferes with their full maturation, accompanied by impaired upregulation of RelB.
Q53123340HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells.
Q43610455Heat effect induces production of inflammatory cytokines through heat shock protein 90 pathway in cornea cells.
Q35517613Heat shock protein-90 inhibitors enhance antigen expression on melanomas and increase T cell recognition of tumor cells
Q37615208Histone H4 expression is cooperatively maintained by IKKβ and Akt1 which attenuates cisplatin-induced apoptosis through the DNA-PK/RIP1/IAPs signaling cascade
Q35823157Hsp90 inhibitors and drug resistance in cancer: the potential benefits of combination therapies of Hsp90 inhibitors and other anti-cancer drugs
Q39552773Quantifying nuclear p65 as a parameter for NF-κB activation: Correlation between ImageStream cytometry, microscopy, and Western blot
Q37151621RIP1 potentiates BPDE-induced transformation in human bronchial epithelial cells through catalase-mediated suppression of excessive reactive oxygen species
Q91522941RIP1 promotes proliferation through G2/M checkpoint progression and mediates cisplatin-induced apoptosis and necroptosis in human ovarian cancer cells
Q38721721Revealing protein networks and gene-drug connectivity in cancer from direct information.
Q37900640The role of inflammation in the pathogenesis of lung cancer

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