HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells.

scientific article

HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10753-016-0343-1
P698PubMed publication ID27075590

P50authorHamid SharifiQ44683637
Gholamabbas MohammadiQ52145472
Mohsen SaravaniQ59157301
P2093author name stringB Kalantari-Khandani
M M Yaghoobi
A Gholamhoseinian Najar
P2860cites workStudy of 5HT3 and HT4 receptor expression in HT29 cell line and human colon adenocarcinoma tissuesQ39734637
Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cellsQ39910109
Nonsteroidal anti-inflammatory drugs suppress glioma via 15-hydroxyprostaglandin dehydrogenaseQ39945648
Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cellsQ40288602
Thioredoxin-1 modulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1alpha in non-small cell lung cancerQ40333166
Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancerQ40350277
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells.Q45980723
17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathwayQ46902088
Direct Transcriptional Up-regulation of Cyclooxygenase-2 by Hypoxia-Inducible Factor (HIF)-1 Promotes Colorectal Tumor Cell Survival and Enhances HIF-1 Transcriptional Activity during HypoxiaQ63362913
Cyclooxygenase-2 is a neuronal target gene of NF-kappaBQ24795366
HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative NeoplasmsQ26778548
HSP90 inhibition suppresses lipopolysaccharide-induced lung inflammation in vivoQ27320833
Nonsteroidal anti-inflammatory drugs in colorectal cancer: from prevention to therapyQ28195436
NF-kappaB in lung cancer, a carcinogenesis mediator and a prevention and therapy targetQ28611413
Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma preventionQ29620087
Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR dataQ33411668
Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cellsQ33757073
The Hsp90 chaperone complex as a novel target for cancer therapyQ34217071
The induction of S100p expression by the Prostaglandin E2(PGE2)/EP4 receptor signaling pathway in colon cancer cellsQ34616607
Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk FactorsQ34624887
Opposite effect of phorbol ester PMA on PTGS2 and PGDH mRNA expression in human chorion trophoblast cellsQ34739513
TGF-β Suppresses COX-2 Expression by Tristetraprolin-Mediated RNA Destabilization in A549 Human Lung Cancer CellsQ34977232
Cyclooxygenase-2: a target for the prevention and treatment of cancers of the upper digestive tractQ35148940
Targeting multiple conformations leads to small molecule inhibitors of the uPAR·uPA protein-protein interaction that block cancer cell invasionQ35563311
COX-2 inhibition as a tool to treat and prevent colorectal cancerQ35925958
PPARδ and PGE2 signaling pathways communicate and connect inflammation to colorectal cancerQ35963300
Anti-inflammatory effect of patchouli alcohol isolated from Pogostemonis Herba in LPS-stimulated RAW264.7 macrophagesQ36230620
Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapyQ36559283
New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential.Q37215989
Cyclooxygenase-2 expression is related to the epithelial-to-mesenchymal transition in human colon cancersQ37485661
15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARγ-mediated activation of p21WAF1/Cip1.Q37549404
15-Hydroxyprostaglandin dehydrogenase as a novel molecular target for cancer chemoprevention and therapyQ37920360
Multifaceted roles of PGE2 in inflammation and cancerQ38045226
Selective COX-2 Inhibitors: A Review of Their Structure-Activity RelationshipsQ38163980
The double-edged sword: conserved functions of extracellular hsp90 in wound healing and cancerQ38210012
Pharmacologic heat shock protein 70 induction confers cytoprotection against inflammation in gliovascular cellsQ38895909
17-Allylamino-17-Demethoxygeldanamycin and the Enhancement of PS-341-Induced Lung Cancer Cell Death by Blocking the NF-κB and PI3K/Akt PathwaysQ38915333
PGE2-induced colon cancer growth is mediated by mTORC1.Q38965450
Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma.Q39109064
Blocking NF-κB and Akt by Hsp90 inhibition sensitizes Smac mimetic compound 3-induced extrinsic apoptosis pathway and results in synergistic cancer cell deathQ39652497
P433issue3
P921main subjectcolorectal cancerQ188874
P304page(s)1116-1123
P577publication date2016-06-01
P1433published inInflammationQ2560341
P1476titleHSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells.
P478volume39

Reverse relations

cites work (P2860)
Q37465746Anti-Inflammatory Effects of Chloranthalactone B in LPS-Stimulated RAW264.7 Cells
Q40144941IL-4 up-regulates cyclooxygenase-1 expression in macrophages.
Q38696076Role of HSPA1L as a cellular prion protein stabilizer in tumor progression via HIF-1α/GP78 axis

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