Human telomerase reverse transcriptase binds to a pre-organized hTR in vivo exposing its template

scientific article published on 19 October 2015

Human telomerase reverse transcriptase binds to a pre-organized hTR in vivo exposing its template is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKV1065
P932PMC publication ID4705647
P698PubMed publication ID26481359
P5875ResearchGate publication ID283050246

P2093author name stringChristina Waldsich
Georgeta Zemora
Stefan Handl
P2860cites workSpecificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivoQ24305098
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRTQ24313396
A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesisQ24323178
Analysis of the structure of human telomerase RNA in vivoQ24514779
Dissecting RNA folding by nucleotide analog interference mapping (NAIM)Q24610481
The telomere syndromesQ24632444
Linking the group II intron catalytic domains: tertiary contacts and structural features of domain 3.Q39705177
Comprehensive structure-function analysis of the core domain of human telomerase RNA.Q39887663
A triple helix within a pseudoknot is a conserved and essential element of telomerase RNA.Q41894058
Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal.Q42057695
RNA conformation in catalytically active human telomeraseQ42766494
Chemical probing of RNA in living cells.Q53086141
Crystal structure of an H/ACA box ribonucleoprotein particle.Q53589609
Structure and function of the smallest vertebrate telomerase RNA from teleost fish.Q54659396
Transfer RNA shields specific nucleotides in 16S ribosomal RNA from attack by chemical probes.Q54771573
A folding control element for tertiary collapse of a group II intron ribozymeQ79401541
Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongationQ81340565
Solution structure and dynamics of the wild-type pseudoknot of human telomerase RNAQ24653322
The solution structure of an essential stem-loop of human telomerase RNAQ27641175
Structural and functional characterization of human telomerase RNA processing and cajal body localization signalsQ27648441
Effect of pseudouridylation on the structure and activity of the catalytically essential P6.1 hairpin in human telomerase RNAQ27662381
Structurally conserved five nucleotide bulge determines the overall topology of the core domain of human telomerase RNAQ27665306
Pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivoQ27678680
Structure and sequence elements of the CR4/5 domain of medaka telomerase RNA important for telomerase functionQ27680870
Structural basis for protein-RNA recognition in telomeraseQ27683630
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptaseQ28138478
Secondary structure of vertebrate telomerase RNAQ28138961
Structure and function of telomerase RNAQ28241332
Identification of a specific telomere terminal transferase activity in Tetrahymena extractsQ28306745
A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenonQ28639770
Triple-helix structure in telomerase RNA contributes to catalysisQ28756914
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesisQ29614741
A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' endQ29615761
Mutation in TERT separates processivity from anchor-site functionQ30446605
Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT.Q30458501
FastCloning: a highly simplified, purification-free, sequence- and ligation-independent PCR cloning methodQ31033460
Template boundary definition in mammalian telomeraseQ33589597
Investigation of human telomerase holoenzyme assembly, activity, and processivity using disease-linked subunit variantsQ33717429
A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA.Q34012344
A self-regulating template in human telomerase.Q34025617
Architecture of human telomerase RNA.Q34208265
The structure of an enzyme-activating fragment of human telomerase RNA.Q34366284
Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for functionQ34400229
Telomere length homeostasis requires that telomerase levels are limitingQ34410927
Telomerase RNA structure and function: implications for dyskeratosis congenita.Q34547087
The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificityQ34687302
Functional importance of telomerase pseudoknot revealed by single-molecule analysisQ35650828
Biogenesis of telomerase ribonucleoproteinsQ36246606
Mapping pseudouridines in RNA moleculesQ38291750
Use of dimethyl sulfate to probe RNA structure in vivoQ38310641
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageQuantQ112270642
P433issue1
P1104number of pages13
P304page(s)413-425
P577publication date2015-10-19
P1433published inNucleic Acids ResearchQ135122
P1476titleHuman telomerase reverse transcriptase binds to a pre-organized hTR in vivo exposing its template
P478volume44

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cites work (P2860)
Q90243303How RNAi machinery enters the world of telomerase
Q89475689Mechanisms of template handling and pseudoknot folding in human telomerase and their manipulation to expand the sequence repertoire of processive repeat synthesis
Q47184251New perspectives on telomerase RNA structure and function
Q39450767Structural biology of telomerase and its interaction at telomeres
Q36035090Telomerase RNA is more than a DNA template
Q28075938Telomerase Regulation from Beginning to the End

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