Genetic variation of iron-induced uroporphyria in mice

scientific article published on April 1993

Genetic variation of iron-induced uroporphyria in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BJ2910029
P932PMC publication ID1132476
P698PubMed publication ID8471047
P5875ResearchGate publication ID14728360

P2093author name stringSmith AG
Francis JE
P2860cites workInvestigations on the role of free radical processes in hexachlorobenzene-induced porphyria in miceQ68050343
Iron and uroporphyrin in hepatocytes of inbred mice in experimental porphyria: a biochemical and morphological studyQ68071090
Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 allelesQ68478197
Sex-linked hepatic uroporphyria and the induction of cytochromes P450IA in rats caused by hexachlorobenzene and polyhalogenated biphenylsQ68486268
Protection against iron-induced uroporphyria in C57BL/10ScSn mice by the peroxisome proliferator nafenopinQ68644646
Role of inducer binding in cytochrome P-450 IA2-mediated uroporphyrinogen oxidationQ68671012
Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylationsQ69114474
Measurement of cytochrome P-450 dependent dealkylation of alkoxyphenoxazones in hepatic S9s and hepatocyte homogenates: effects of dicumarolQ69381361
Uroporphyria caused by acetone and 5-aminolevulinic acid in iron-loaded miceQ69403215
Pleiotropic effect of the gene hairless on hepatotoxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in miceQ69416113
Iron removal therapy in porphyria cutanea tarda: phlebotomy versus slow subcutaneous desferrioxamine infusionQ69540081
Effect of desferrioxamine on the development of hexachlorobenzene-induced porphyriaQ69586167
The murine Ah locus: a new allele and mapping to chromosome 12Q69810190
Oxidation of uroporphyrinogens by hydroxyl radicals. Evidence for nonporphyrin products as potential inhibitors of uroporphyrinogen decarboxylaseQ69830407
The role of iron in the toxicity of 2,3,7,8-tetrachlorodibenzo-(p)-dioxin (TCDD)Q70959490
Dependence of the porphyrogenic effect of 2,3,7,8-tetrachlorodibenzo(p)dioxin upon inheritance of aryl hydrocarbon hydroxylase responsivenessQ71225920
In vitro inhibitory effect on porphyrinogen carboxylyase of liver extracts from TCDD treated miceQ71266021
Urine and faecal porphyrin profiles by reversed-phase high-performance liquid chromatography in the porphyriasQ71350915
Iron storage in porphyria cutanea tardaQ71665335
Induction of Hepatic δ-Aminolevulinic Acid Synthetase Activity in Strains of Inbred MiceQ71755429
A simple technique for measuring storage iron concentrations in formalinised liver samplesQ72104635
Protein measurement with the Folin phenol reagentQ20900776
Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2Q28319534
The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J miceQ28359863
Rare structural variants of human and murine uroporphyrinogen I synthaseQ36389804
The Ah receptor and the mechanism of dioxin toxicityQ36390569
Isolation of a rat liver delta-aminolevulinate dehydrase (ALAD) cDNA clone: evidence for unequal ALAD gene dosage among inbred mouse strainsQ36460920
The pathology of hepatic iron overload: a free radical--mediated process?Q37870467
Oxidative injury mediated by the hepatic cytochrome P-450 system in conjunction with cellular iron. Effects on the pathway of haem biosynthesisQ37990265
Experimental porphyriaQ39312894
Toxicological aspects of liver heme biosynthesisQ39556858
Porphyria cutanea tarda, or the uroporphyrinogen decarboxylase deficiency diseasesQ39729523
Uroporphyria produced in mice by iron and 5-aminolevulinic acidQ41186367
HLA-linked hemochromatosis alleles in sporadic porphyria cutanea tardaQ41326433
Role of iron in the hydrogen peroxide-dependent oxidation of hexahydroporphyrins (porphyrinogens): a possible mechanism for the exacerbation by iron of hepatic uroporphyria.Q41388086
Heterozygosity for HLA-linked hemochromatosis as a likely cause of the hepatic siderosis associated with sporadic porphyria cutanea tardaQ41496135
Iron Deficiency Prevents Liver Toxicity of 2,3,7,8-Tetrachlorodibenzo- p -DioxinQ41521465
Identification of meso-hydroxyuroporphyrin I in the urine of a patient with congenital erythropoietic porphyriaQ41763290
Chemically-induced formation of an inhibitor of hepatic uroporphyrinogen decarboxylase in inbred mice with iron overloadQ41860271
Oxidation of uroporphyrinogen by methylcholanthrene-induced cytochrome P-450. Essential role of cytochrome P-450dQ41894823
Synergism of iron and hexachlorobenzene inhibits hepatic uroporphyrinogen decarboxylase in inbred miceQ41938430
Multiple forms of cytochrome P-450 related to forms induced marginally by phenobarbital. Differences in structure and in the metabolism of alkoxyresorufinsQ42165163
Distinction between octachlorostyrene and hexachlorobenzene in their potentials to induce ethoxyphenoxazone deethylase and cause porphyria in rats and miceQ42212237
Mechanistic studies of the inhibition of hepatic uroporphyrinogen decarboxylase in C57BL/10 mice by iron-hexachlorobenzene synergismQ42854602
Uroporphyria produced in mice by 20-methylcholanthrene and 5-aminolaevulinic acidQ42858662
Iron and hepatic uroporphyrin synthesis. Relation in porphyria cutanea tardaQ43545586
Free radical mechanism of oxidation of uroporphyrinogen in the presence of ferrous ironQ44278223
Experimental porphyrias as models for human hepatic porphyriasQ44701010
Immunoreactive uroporphyrinogen decarboxylase in the liver in porphyria cutanea tardaQ44872150
Carcinogenicity of iron in conjunction with a chlorinated environmental chemical, hexachlorobenzene, in C57BL/10ScSn miceQ45137320
Linkage analyses using biochemical variants in mice. II. Levulinate dehydratase and autosomal glucose 6-phosphate dehydrogenaseQ45269597
Investigations on the presence of porphyrinogen carboxy-lyase inhibitor in the liver of rats intoxicated with hexachlorobenzeneQ52535345
Induction of 8-hydroxydeoxyguanosine in Ah-responsive mouse liver by iron and Aroclor 1254Q53492356
Iron as a synergist for hepatocellular carcinoma induced by polychlorinated biphenyls in Ah-responsive C57BL/10ScSn miceQ53509364
Low rate of NADPH/ADP-iron dependent lipid peroxidation in hepatic microsomes of DBA/2 miceQ54449975
Incomplete correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin hepatotoxicity with Ah phenotype in miceQ54472965
Genetic variance of laboratory outbred Swiss miceQ59062723
P407language of work or nameEnglishQ1860
P921main subjectgenetic variationQ349856
P304page(s)29-35
P577publication date1993-04-01
P1433published inBiochemical JournalQ864221
P1476titleGenetic variation of iron-induced uroporphyria in mice
P478volume291 ( Pt 1)

Reverse relations

cites work (P2860)
Q28507743A mouse model of familial porphyria cutanea tarda
Q24681370A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda
Q46290725Absolute requirement for iron in the development of chemically induced uroporphyria in mice treated with 3-methylcholanthrene and 5-aminolevulinate
Q34555359Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal
Q44448362Experimental hepatic uroporphyria induced by the diphenyl-ether herbicide fomesafen in male DBA/2 mice
Q33609861Hyper- and hypo-induction of cytochrome P450 activities with Aroclor 1254 and 3-methylcholanthrene in Cyp1a2(-/-) mice
Q73048056Increased frequency of the haemochromatosis Cys282Tyr mutation in sporadic porphyria cutanea tarda
Q46497692Inducing coproporphyria in rat hepatocyte cultures using cyclic AMP and cyclic AMP-releasing agents
Q42545416Interaction between Iron Metabolism and 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mice with Variants of the Ahr Gene: A Hepatic Oxidative Mechanism
Q72285937Isolation and characterization of extragenic mutations affecting the expression of the uroporphyrinogen decarboxylase gene (HEM12) in Sacharomyces cerevisiae
Q77893629Liver preneoplastic changes in mice treated with the herbicide fomesafen
Q48771719Minimal ischaemic neuronal damage and HSP70 expression in MF1 strain mice following bilateral common carotid artery occlusion.
Q78049632Role of small differences in CYP1A2 in the development of uroporphyria produced by iron and 5-aminolevulinate in C57BL/6 and SWR strains of mice
Q74178122Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice
Q28579667The decrease in uroporphyrinogen decarboxylase activity induced by ethanol predisposes rats to the development of porphyria and accelerates xenobiotic-triggered porphyria, regardless of hepatic damage
Q42519264Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron
Q39345761Uroporphyria in the Cyp1a2-/- mouse
Q42527457Uroporphyria induced by 5-aminolaevulinic acid alone in Ahrd SWR mice
Q28506791Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(−/−) null mutant mice
Q40433950Uroporphyrinogen decarboxylase

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