Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron

scientific article

Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1053/JHEP.2002.32487
P698PubMed publication ID11915039
P5875ResearchGate publication ID11449575

P2093author name stringDaniel W Nebert
Richard S Eisenstein
Glenn S Gerhard
Timothy P Dalton
Kerry L Ross
Jacqueline F Sinclair
Nadia Gorman
Peter R Sinclair
Heidi S Walton
Juliana G Szakacs
William J Bement
P2860cites workIron regulatory proteins and the molecular control of mammalian iron metabolismQ28143426
Inhibition of uroporphyrinogen decarboxylase by halogenated biphenyls in chick hepatocyte cultures. Essential role for induction of cytochrome P-448Q28366673
A mouse model of familial porphyria cutanea tardaQ28507743
Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolismQ28510829
Uroporphyria in Hfe mutant mice given 5-aminolevulinate: a new model of Fe-mediated porphyria cutanea tardaQ31921576
Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancerQ40992263
Iron Deficiency Prevents Liver Toxicity of 2,3,7,8-Tetrachlorodibenzo- p -DioxinQ41521465
Porphyria Cutanea Tarda of the Toxic and Sporadic VarietiesQ41745505
Inhibition of uroporphyrinogen decarboxylase activity. The role of cytochrome P-450-mediated uroporphyrinogen oxidationQ41868201
Synergism of iron and hexachlorobenzene inhibits hepatic uroporphyrinogen decarboxylase in inbred miceQ41938430
Genetic variation of iron-induced uroporphyria in miceQ41969993
Uroporphyria induced by 5-aminolaevulinic acid alone in Ahrd SWR miceQ42527457
Ascorbic acid deficiency in porphyria cutanea tardaQ42547915
Porphyria cutanea tarda, hepatitis C, and HFE gene mutations in north america†Q42988426
Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxinQ43624937
Multiple Roles of Polyhalogenated Biphenyls in Causing Increases in Cytochrome P450 and Uroporphyrin Accumulation in Cultured HepatocytesQ48771416
Chlorinated biphenyls induce cytochrome P450IA2 and uroporphyrin accumulation in cultures of mouse hepatocytesQ54317196
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)912-921
P577publication date2002-04-01
P1433published inHepatologyQ15724398
P1476titleUroporphyria in mice: thresholds for hepatic CYP1A2 and iron
P478volume35

Reverse relations

cites work (P2860)
Q24681370A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda
Q41730972Activity of cytochrome P450 1A2 in relation to hepatic iron accumulation in transfusion-dependent β-thalassaemia major patients
Q84587889Attenuation of polychlorinated biphenyl induced uroporphyria by iron deprivation
Q24815975Biomarker measurements in a coastal fish-eating population environmentally exposed to organochlorines
Q81247403Effect of an oral iron chelator or iron-deficient diets on uroporphyria in a murine model of porphyria cutanea tarda
Q79449900Effect of iron and ascorbate on uroporphyria in ascorbate-requiring mice as a model for porphyria cutanea tarda
Q44557689Export of a heterologous cytochrome P450 (CYP105D1) in Escherichia coli is associated with periplasmic accumulation of uroporphyrin
Q28586157For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential
Q45070103Genetic factors influence ethanol-induced uroporphyria in Hfe(-/-) mice
Q35212534Iron as a co-morbid factor in nonhemochromatotic liver disease
Q36871056Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs
Q39345761Uroporphyria in the Cyp1a2-/- mouse
Q44301824Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda

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