A derivatized scorpion toxin reveals the functional output of heteromeric KCNQ1-KCNE K+ channel complexes

scientific article published on 29 June 2007

A derivatized scorpion toxin reveals the functional output of heteromeric KCNQ1-KCNE K+ channel complexes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/CB700089S
P932PMC publication ID2561296
P698PubMed publication ID17602620
P5875ResearchGate publication ID6234248

P2093author name stringTrevor J Morin
William R Kobertz
P2860cites workA constitutively open potassium channel formed by KCNQ1 and KCNE3Q22011154
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channelQ24318271
KCNE4 is an inhibitory subunit to the KCNQ1 channelQ24642042
Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2Q28145423
The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretionQ28244406
Expression and transcriptional control of human KCNE genesQ28283081
The MinK-related peptidesQ28291767
K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium currentQ28295470
Nuclear magnetic resonance structural studies of a potassium channel-charybdotoxin complex.Q30351969
Expression of multiple KCNE genes in human heart may enable variable modulation of I(Ks).Q34392041
Inner ear defects induced by null mutation of the isk geneQ34412325
In vitro molecular interactions and distribution of KCNE family with KCNQ1 in the human heartQ34436223
KCNE1 subunits require co-assembly with K+ channels for efficient trafficking and cell surface expressionQ40215685
KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channelsQ41882406
Small vertical movement of a K+ channel voltage sensor measured with luminescence energy transferQ43247729
KCNE2 is colocalized with KCNQ1 and KCNE1 in cardiac myocytes and may function as a negative modulator of I(Ks) current amplitude in the heartQ44925365
Tethered blockers as molecular 'tape measures' for a voltage-gated K+ channelQ48893608
Subunit composition of minK potassium channels.Q49051317
The charybdotoxin receptor of a Shaker K+ channel: peptide and channel residues mediating molecular recognitionQ49104191
Mutational spectrum in the cardioauditory syndrome of Jervell and Lange-Nielsen.Q50493312
Alteration of channel activities and gating by mutations of slow ISK potassium channel.Q50796495
Engineering a uniquely reactive thiol into a cysteine-rich peptide.Q54637204
Charybdotoxin Binding in the IKs Pore Demonstrates Two MinK Subunits in Each Channel ComplexQ58482877
Purification of charybdotoxin, a specific inhibitor of the high-conductance Ca2+-activated K+ channelQ68976598
MinK-KvLQT1 fusion proteins, evidence for multiple stoichiometries of the assembled IsK channelQ77677778
P433issue7
P304page(s)469-473
P577publication date2007-06-29
P1433published inACS Chemical BiologyQ165583
P1476titleA derivatized scorpion toxin reveals the functional output of heteromeric KCNQ1-KCNE K+ channel complexes
P478volume2

Reverse relations

cites work (P2860)
Q35165386Chemical control of metabolically-engineered voltage-gated K+ channels
Q42081611Chemical derivatization and purification of peptide-toxins for probing ion channel complexes
Q33396331Chemical tools for K(+) channel biology
Q36446328Counting membrane-embedded KCNE beta-subunits in functioning K+ channel complexes
Q37580457Delayed rectifier K(+) currents and cardiac repolarization.
Q41296959Does a physiological role for KCNE subunits exist in the immune system?
Q24647091Dynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2
Q28235159Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits
Q36667897KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains
Q46078668Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome
Q41433606SUMOylation determines the voltage required to activate cardiac IKs channels
Q28583726Stoichiometry of the KCNQ1 - KCNE1 ion channel complex.
Q37412583Structural basis for K(V)7.1-KCNE(x) interactions in the I(Ks) channel complex
Q37187059Tethering chemistry and K+ channels
Q57490689The I Channel Response to cAMP Is Modulated by the KCNE1:KCNQ1 Stoichiometry
Q46677905The envenomation of general physiology throughout the last century
Q34117222The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner
Q39477676Unnatural amino acid photo-crosslinking of the IKs channel complex demonstrates a KCNE1:KCNQ1 stoichiometry of up to 4:4.

Search more.