Mutation in the U2 snRNA influences exon interactions of U5 snRNA loop 1 during pre-mRNA splicing

scientific article published on 3 August 2006

Mutation in the U2 snRNA influences exon interactions of U5 snRNA loop 1 during pre-mRNA splicing is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.EMBOJ.7601258
P932PMC publication ID1553196
P698PubMed publication ID16888626
P5875ResearchGate publication ID6897466

P2093author name stringRaymond T O'Keefe
Joanne C McGrail
Elaine M Tatum
P2860cites worksnRNA interactions at 5' and 3' splice sites monitored by photoactivated crosslinking in yeast spliceosomesQ24539157
Analysis of Snu13p mutations reveals differential interactions with the U4 snRNA and U3 snoRNAQ27932103
Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicingQ27933470
Yeast vectors for the controlled expression of heterologous proteins in different genetic backgroundsQ28131643
Spliceosomal UsnRNP biogenesis, structure and functionQ28188106
A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosomeQ28201291
A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicingQ28259233
ATP-dependent interaction of yeast U5 snRNA loop 1 with the 5' splice siteQ28343834
Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiaeQ29620268
Mutations in U5 snRNA loop 1 influence the splicing of different genes in vivoQ31121941
Functional analysis of the U5 snRNA loop 1 in the second catalytic step of yeast pre-mRNA splicingQ33888130
Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1Q33960716
A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeastQ34362402
Identification of a U2/U6 helix la mutant that influences 3' splice site selection during nuclear pre-mRNA splicingQ34362884
The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assemblyQ34364667
Randomization-selection analysis of snRNAs in vivo: evidence for a tertiary interaction in the spliceosomeQ36723537
In vitro reconstitution of functional yeast U2 snRNPsQ38342925
Site-specific crosslinks of yeast U6 snRNA to the pre-mRNA near the 5' splice site.Q40926230
A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicingQ41354468
Multiple functions for the invariant AGC triad of U6 snRNA.Q41815683
Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome.Q42679830
Genetic interaction between U6 snRNA and the first intron nucleotide in Saccharomyces cerevisiaeQ43206190
A role for U2/U6 helix Ib in 5' splice site selectionQ43206273
Genomic-scale quantitative analysis of yeast pre-mRNA splicing: implications for splice-site recognitionQ43206495
A handful of intron-containing genes produces the lion's share of yeast mRNA.Q43206498
Two domains of yeast U6 small nuclear RNA required for both steps of nuclear precursor messenger RNA splicingQ44931710
Mutational analysis of the yeast U2 snRNA suggests a structural similarity to the catalytic core of group I intronsQ45974493
In vitro assembly of yeast U6 snRNP: a functional assayQ46978210
U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junctionQ57080150
The U5 and U6 small nuclear RNAs as active site components of the spliceosomeQ64383669
U5 snRNA interacts with exon sequences at 5′ and 3′ splice sitesQ67753779
Functionally redundant interactions between U2 and U6 spliceosomal snRNAsQ70997761
The invariant U5 snRNA loop 1 sequence is dispensable for the first catalytic step of pre-mRNA splicing in yeastQ71382076
Dynamic exchanges of RNA interactions leading to catalytic core formation in the U12-dependent spliceosomeQ73427970
P433issue16
P407language of work or nameEnglishQ1860
P304page(s)3813-3822
P577publication date2006-08-03
P1433published inThe EMBO JournalQ1278554
P1476titleMutation in the U2 snRNA influences exon interactions of U5 snRNA loop 1 during pre-mRNA splicing
P478volume25

Reverse relations

cites work (P2860)
Q42251299Analysis of synthetic lethality reveals genetic interactions between the GTPase Snu114p and snRNAs in the catalytic core of the Saccharomyces cerevisiae spliceosome
Q41764126Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps
Q27935202Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing
Q42110809In vitro reconstitution of yeast splicing with U4 snRNA reveals multiple roles for the 3' stem-loop
Q39978710Insights into branch nucleophile positioning and activation from an orthogonal pre-mRNA splicing system in yeast
Q34248744Mutation of a U2 snRNA gene causes global disruption of alternative splicing and neurodegeneration
Q43103473Mutations in the U5 snRNA result in altered splicing of subsets of pre-mRNAs and reduced stability of Prp8.
Q50961823Powering a two-stroke RNA engine.
Q34132148Spliceosomal snRNA modifications and their function
Q34528466Splint ligation of RNA with T4 DNA ligase
Q41878070The NineTeen Complex (NTC) and NTC-associated proteins as targets for spliceosomal ATPase action during pre-mRNA splicing
Q35783047The Prp18 protein stabilizes the interaction of both exons with the U5 snRNA during the second step of pre-mRNA splicing
Q27931506The RNA binding protein Cwc2 interacts directly with the U6 snRNA to link the nineteen complex to the spliceosome during pre-mRNA splicing
Q36457093The U1, U2 and U5 snRNAs crosslink to the 5' exon during yeast pre-mRNA splicing
Q40949360The U5 snRNA internal loop 1 is a platform for Brr2, Snu114 and Prp8 protein binding during U5 snRNP assembly
Q37947529The mechanism of the second step of pre-mRNA splicing

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