Mahogunin-mediated α-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation

scientific article published on 20 February 2014

Mahogunin-mediated α-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/CDDIS.2014.1
P932PMC publication ID3944237
P698PubMed publication ID24556679
P5875ResearchGate publication ID260370928

P2093author name stringD Srivastava
O Chakrabarti
P2860cites workFamilial Parkinson disease gene product, parkin, is a ubiquitin-protein ligaseQ22254584
The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sitesQ24293033
Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal traffickingQ24293322
Huntingtin is required for mitotic spindle orientation and mammalian neurogenesisQ24294765
The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitinQ24312959
Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residuesQ24313165
BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome numberQ37515419
p53 regulation by ubiquitinQ37882073
Ubiquitin editing enzyme UCH L1 and microtubule dynamics: implication in mitosisQ39738670
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseasesQ40056959
BRCA1 regulates gamma-tubulin binding to centrosomesQ41922227
Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathwayQ41993614
Support for the selective chromatid segregation hypothesis advanced for the mechanism of left-right body axis development in mice.Q51946212
Mice with mutations in Mahogunin ring finger-1 (Mgrn1) exhibit abnormal patterning of the left-right axis.Q52003130
Dynein and dynactin are localized to astral microtubules and at cortical sites in mitotic epithelial cells.Q52187841
Novel multiubiquitin chain linkages catalyzed by the conjugating enzymes E2EPF and RAD6 are recognized by 26 S proteasome subunit 5Q70937723
Microtubule basis for left-handed helical growth in ArabidopsisQ74054031
Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosisQ24315967
The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolaseQ24527361
Formation of spindle poles by dynein/dynactin-dependent transport of NuMAQ24670127
Non-canonical ubiquitin-based signals for proteasomal degradationQ26825366
Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae.Q27932166
Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligaseQ28187365
Microtubule polymerization dynamicsQ28259930
Spongiform degeneration in mahoganoid mutant miceQ28506434
Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradationQ28572388
Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashionQ30477500
Reduced translocation of nascent prion protein during ER stress contributes to neurodegenerationQ30483989
Mutations in a beta-tubulin disrupt spindle orientation and microtubule dynamics in the early Caenorhabditis elegans embryoQ30487651
Cell movements at Hensen's node establish left/right asymmetric gene expression in the chick.Q30497478
The cilia protein IFT88 is required for spindle orientation in mitosisQ30499405
Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegenerationQ33289413
The BRCA1 E3 ubiquitin ligase controls centrosome dynamicsQ33343140
E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alphaQ33953327
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibilityQ34157005
Post-translational modifications of microtubulesQ34182922
Early, nonciliary role for microtubule proteins in left-right patterning is conserved across kingdomsQ34288592
Microtubule defects and cell morphogenesis in the lefty1lefty2 tubulin mutant of Arabidopsis thalianaQ34301692
Ubiquitin enters the new millenniumQ34388963
Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex.Q34434485
Transgenic analysis of the physiological functions of Mahogunin Ring Finger-1 isoformsQ34564123
Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion diseaseQ34576746
Prion protein biosynthesis and its emerging role in neurodegenerationQ35094535
Huntingtin facilitates dynein/dynactin-mediated vesicle transport.Q35840466
Ubiquitin-proteasome system and Parkinson's diseasesQ35998400
Human laterality disordersQ36388233
Left-right patterning from the inside out: widespread evidence for intracellular control.Q36733988
The functions of UCH-L1 and its relation to neurodegenerative diseasesQ36856806
Strategies to establish left/right asymmetry in vertebrates and invertebratesQ36888189
Control at the cell center: the role of spindle poles in cytoskeletal organization and cell cycle regulationQ36995003
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectprotein ubiquitinationQ3547638
P304page(s)e1064
P577publication date2014-02-20
P1433published inCell Death and DiseaseQ2197222
P1476titleMahogunin-mediated α-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation
P478volume5

Reverse relations

cites work (P2860)
Q33746251Cellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario.
Q27334688Conserved roles for cytoskeletal components in determining laterality
Q64915295Dissecting the role of the tubulin code in mitosis.
Q39002176From cytoskeletal dynamics to organ asymmetry: a nonlinear, regulative pathway underlies left-right patterning
Q88796724K6 linked polyubiquitylation of FADD by CHIP prevents death inducing signaling complex formation suppressing cell death
Q58257407Lnx2b, an E3 ubiquitin ligase, in dorsal forerunner cells and Kupffer's vesicle is required for specification of zebrafish left–right laterality
Q48115125MGRN1-mediated ubiquitination of α-tubulin regulates microtubule dynamics and intracellular transport
Q38563041Mahogunin Ring Finger-1 (MGRN1), a Multifaceted Ubiquitin Ligase: Recent Unraveling of Neurobiological Mechanisms
Q38821869Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101.
Q51607668Mahogunin-mediated regulation of Gαi localisation during mitosis and its effect on spindle positioning.
Q90350244Posttranslational modification of plant microtubules
Q104482079Tubulin post-translational modifications control neuronal development and functions
Q41662068Tumor susceptibility gene 101 regulates predisposition to apoptosis via ESCRT machinery accessory proteins
Q38537596Ubiquitin in regulation of spindle apparatus and its positioning: implications in development and disease

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