CXCR4 in Cancer and Its Regulation by PPARgamma

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CXCR4 in Cancer and Its Regulation by PPARgamma is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1155/2008/769413
P932PMC publication ID2528256
P698PubMed publication ID18779872
P5875ResearchGate publication ID23245646

P50authorJonathan BlayQ56256636
P2093author name stringCynthia Lee Richard
P2860cites workHIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled ReceptorQ22242268
Involvement of chemokine receptors in breast cancer metastasisQ24290909
Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1Q24310870
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entryQ24315492
Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytesQ24324518
MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail functionQ24538996
Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathwayQ24558745
Expression of functional CXCR4 chemokine receptors on human colonic epithelial cellsQ24563114
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodiesQ24681266
Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinomaQ24803472
International union of pharmacology. XXII. Nomenclature for chemokine receptorsQ28145705
Sequential induction of prostaglandin E and D synthases in inflammationQ28186256
Prostaglandins and leukotrienes: advances in eicosanoid biologyQ28208246
Altered eicosanoid levels in human colon cancerQ28255943
The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancersQ28262445
The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytesQ28267757
Genomic organization and promoter characterization of human CXCR4 geneQ28271622
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancerQ28274188
Quantification of prostaglandin D synthetase in cerebrospinal fluid: a potential marker for brain tumorQ28290831
CXCR4 regulates growth of both primary and metastatic breast cancerQ28296113
Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridomaQ28344144
Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX miceQ28368272
The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tractQ28504884
Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathwaysQ28511859
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar developmentQ28512895
15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancerQ28592082
Tumour-educated macrophages promote tumour progression and metastasisQ29614307
siRNAs can function as miRNAsQ29615070
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gammaQ29615221
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)Q29615693
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1Q29616092
The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1Q29616093
The biology of chemokines and their receptorsQ29619170
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiationQ29619212
Gene expression of cyclooxygenase-2, group II and cytosolic phospholipase A2 in human colorectal cancerQ77703474
Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cellsQ78710357
CXC chemokine receptor 4 expression and function in human anaplastic thyroid cancer cellsQ78767913
Association of CXCR4 and CCR7 chemokine receptor expression and lymph node metastasis in human cervical cancerQ79219726
SDF-1 plays a key role in the repairing and remodeling process on rat allo-orthotopic abdominal aorta graftsQ79715671
Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancerQ79790905
Expression of growth factor and chemokine receptors: new insights in the biology of inflammatory breast cancerQ79918235
The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularizationQ80376104
Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancerQ80506644
Association between expression of vascular endothelial growth factor C, chemokine receptor CXCR4 and lymph node metastasis in colorectal cancerQ80643044
CXC chemokine receptor-4 antagonist blocks both growth of primary tumor and metastasis of head and neck cancer in xenograft mouse modelsQ80726314
A significant correlation between nuclear CXCR4 expression and axillary lymph node metastasis in hormonal receptor negative breast cancerQ80975600
CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancerQ81098644
Chemokine receptor CXCR4 expression in breast cancer as a potential predictive marker of isolated tumor cells in bone marrowQ81139820
Possible involvement of SDF-1alpha/CXCR4-DPPIV axis in TGF-beta1-induced enhancement of migratory potential in human peritoneal mesothelial cellsQ81230145
Preferential expression of chemokine receptor CXCR4 by highly malignant human gliomas and its association with poor patient survivalQ81325774
Blockade of invasion and metastasis of breast cancer cells via targeting CXCR4 with an artificial microRNAQ81340909
Expression of CXCR4 is associated with axillary lymph node status in patients with early breast cancerQ81379933
Augmented mobilization and collection of CD34+ hematopoietic cells from normal human volunteers stimulated with granulocyte-colony-stimulating factor by single-dose administration of AMD3100, a CXCR4 antagonistQ81487164
Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancerQ82040938
CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasisQ82782774
Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatase(s) and reducing ERK1/2 activity via a novel pathwayQ83149943
Expression of chemokine CXCL12 and its receptor CXCR4 in human epithelial ovarian cancer: an independent prognostic factor for tumor progressionQ83187267
Chemokines and cancerQ83278273
Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancerQ48575675
High expression of the chemokine receptor CXCR4 predicts extramedullary organ infiltration in childhood acute lymphoblastic leukaemiaQ48694724
CXC chemokine receptor 4 expression and function in human astroglioma cellsQ49071824
A pharmacokinetic-pharmacodynamic model for the mobilization of CD34+ hematopoietic progenitor cells by AMD3100.Q50767910
CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion.Q52834072
Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer.Q53276834
Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer.Q53362101
Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in vivo.Q53461247
A gene expression signature associated with metastatic cells in effusions of breast carcinoma patients.Q53558013
CXCR4 is a prognostic marker in acute myelogenous leukemia.Q53607339
The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study.Q53644477
Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells.Q54628926
Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival.Q54669043
Peroxisome proliferator-activated receptor gamma induces growth arrest and differentiation markers of human colon cancer cells.Q54948587
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomasQ29620630
Molecular biology of bone metastasisQ30444749
Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazoneQ31399843
Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection.Q33362778
In vivo distribution of the human immunodeficiency virus/simian immunodeficiency virus coreceptors: CXCR4, CCR3, and CCR5.Q33784206
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinaseQ33886831
Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteersQ33979799
Structure and function of adenosine receptors and their genes.Q34101838
CXCR4/CXCL12 expression and signalling in kidney cancerQ34123763
Expression of cytosolic and group X secretory phospholipase A(2) genes in human colorectal adenocarcinomasQ34131695
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.Q34178157
Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency diseaseQ34190328
CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivoQ34357222
Patients with adenomatous polyps and carcinomas have increased colonic mucosal prostaglandin E2Q34378716
An overview on biological mechanisms of PPARs.Q34381038
Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axisQ34418159
The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF aloneQ34418466
International Union of Pharmacology. XLVI. G protein-coupled receptor list.Q34421152
The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasiaQ34423141
COX-2: a target for colon cancer preventionQ34504020
Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2.Q34568144
Adenosine down-regulates the surface expression of dipeptidyl peptidase IV on HT-29 human colorectal carcinoma cells: implications for cancer cell behaviorQ35102870
The bicyclam AMD3100 storyQ35158014
Differential expression of cyclooxygenase 2 in human colorectal cancerQ35357611
15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.Q35698498
Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progressionQ35735316
Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha.Q35786830
The significance of cancer cell expression of the chemokine receptor CXCR4.Q35832343
Tumor microenvironmental physiology and its implications for radiation oncologyQ35837012
CXCR4/CXCL12 axis promotes VEGF-mediated tumor angiogenesis through Akt signaling pathwayQ36003309
The role of prostaglandins and other eicosanoids in the gastrointestinal tractQ36123763
Matrigel: basement membrane matrix with biological activityQ36173565
Regulation of the chemokine receptor CXCR4 by hypoxiaQ36371842
The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood.Q36376700
Recapitulation of short RNA-directed translational gene silencing in vitroQ56899069
Blockade of the Stromal Cell–Derived Factor-1/CXCR4 Axis AttenuatesIn vivoTumor Growth by Inhibiting Angiogenesis in a Vascular Endothelial Growth Factor–Independent MannerQ57078137
CXCL12-3′A Polymorphism and lung cancer metastases protection: new perspectives in immunotherapy?Q58835521
Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to boneQ60504419
Expression of tumour necrosis factor (TNFα) and its receptors in benign and malignant breast tissueQ61819262
Inhibitory effects of anti-CXCR4 antibodies on human colon cancer cellsQ63247802
Expression of CXCR4 Predicts Poor Prognosis in Patients with Malignant MelanomaQ63247804
Differences of metabolism of prostaglandin E2 and F2 alpha by decidual stromal cells and macrophages in cultureQ67856549
delta 12-Prostaglandin J2, an ultimate metabolite of prostaglandin D2 exerting cell growth inhibitionQ69835332
Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitroQ70915009
Overexpression of the chemokine receptor CXCR4 in B cell chronic lymphocytic leukemia is associated with increased functional response to stromal cell-derived factor-1 (SDF-1)Q73283069
The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosineQ73470605
The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastasesQ73608635
Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic miceQ73693790
T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancerQ73847638
CXCR4 neutralization, a novel therapeutic approach for non-Hodgkin's lymphomaQ74198916
CXCR4 expression is associated with survival in familial chronic lymphocytic leukemia, but CD38 expression is notQ74545601
A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastomaQ74601897
Inhibitory effects of prostaglandin D2 against the proliferation of human colon cancer cell lines and hepatic metastasis from colorectal cancerQ77063686
Activation of PPARgamma leads to inhibition of anchorage-independent growth of human colorectal cancer cellsQ77494182
TNF-alpha in promotion and progression of cancerQ36585132
Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4.Q36612087
Bone-derived SDF-1 stimulates IL-6 release via CXCR4, ERK and NF-kappaB pathways and promotes osteoclastogenesis in human oral cancer cellsQ36838004
Breast cancer brain metastasesQ36918681
Silencing of CXCR4 blocks breast cancer metastasisQ37074006
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.Q37089440
Prostaglandin levels in human colorectal mucosa: effects of sulindac in patients with familial adenomatous polyposisQ37237357
Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancerQ37269372
Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effectQ37605758
15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implicationsQ38329568
Inactivation of HIV-1 chemokine co-receptor CXCR-4 by a novel intrakine strategyQ38941762
Inhibition of CXCR4 activity with AMD3100 decreases invasion of human colorectal cancer cells in vitroQ39991423
Up-regulation of stromal cell-derived factor-1alpha and its receptor CXCR4 expression accompanied with epithelial-mesenchymal transition in human oral squamous cell carcinoma.Q39999861
Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cellsQ40002532
15-Deoxy-delta(12,14)-prostaglandin J(2) down-regulates CXCR4 on carcinoma cells through PPARgamma- and NFkappaB-mediated pathways.Q40091899
Role of CXCL12 in metastasis of human ovarian cancer.Q40094482
Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cellsQ40108758
Rho activation regulates CXCL12 chemokine stimulated actin rearrangement and restitution in model intestinal epithelia.Q40119156
Thiazolidinedione drugs down-regulate CXCR4 expression on human colorectal cancer cells in a peroxisome proliferator activated receptor gamma-dependent manner.Q40153588
Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasionQ40213967
Adenosine upregulates CXCR4 and enhances the proliferative and migratory responses of human carcinoma cells to CXCL12/SDF-1alpha.Q40258406
Lower expression of CXCR4 in lymph node metastases than in primary breast cancers: potential regulation by ligand-dependent degradation and HIF-1alphaQ40271040
Overexpression of both CXC chemokine receptor 4 and vascular endothelial growth factor proteins predicts early distant relapse in stage II-III colorectal cancer patientsQ40283597
Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancerQ40314315
The inflammatory cytokine tumor necrosis factor-alpha regulates chemokine receptor expression on ovarian cancer cellsQ40351465
The elevated level of CXCR4 is correlated with nodal metastasis of human breast cancerQ40363410
Activation of chemokine receptor CXCR4 in malignant glioma cells promotes the production of vascular endothelial growth factorQ40387859
CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activationQ40390514
Suppression of prostate tumor cell growth by stromal cell prostaglandin D synthase-derived productsQ40396841
Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesisQ40400042
The expression of functional chemokine receptor CXCR4 is associated with the metastatic potential of human nasopharyngeal carcinomaQ40401192
SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion.Q40406965
Characterization and enumeration of cells secreting tumor markers in the peripheral blood of breast cancer patients.Q40417804
Expression of CXCR4 and its down-regulation by IFN-gamma in head and neck squamous cell carcinomaQ40429792
Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcomaQ40438081
CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells.Q40439589
Alpha,beta-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma.Q40461294
Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4.Q40490606
15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins.Q40501213
CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasionQ40507455
Interaction of ligand-receptor system between stromal-cell-derived factor-1 and CXC chemokine receptor 4 in human prostate cancer: a possible predictor of metastasisQ40538377
Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cellsQ40538962
A single treatment with microcapsules containing a CXCR4 antagonist suppresses pulmonary metastasis of murine melanomaQ40543358
Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4.Q40543795
Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasisQ40548697
Stromal cell-derived factor-1alpha-induced cell proliferation and its possible regulation by CD26/dipeptidyl peptidase IV in endometrial adenocarcinomaQ40555406
Stromal cell-derived factor-1alpha promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities.Q40570934
Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor gamma (PPAR gamma) ligand, 15-deoxy-delta 12,14prostaglandin J2 (15-d-PGJ2).Q40586826
Stromal-derived factor-1alpha/CXCL12-CXCR 4 axis is involved in the dissemination of NSCLC cells into pleural spaceQ40607879
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.Q40633683
Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cellsQ40692637
Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancerQ40696855
T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activitiesQ40747044
Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophyQ40747279
15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processesQ40757735
Expression of functional chemokine receptors CXCR3 and CXCR4 on human melanoma cellsQ40778652
The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells.Q40780948
Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progressionQ40853389
Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cellsQ40925778
Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) geneQ41312923
Chemokine receptor expression by human intestinal epithelial cellsQ41681584
Role of prostaglandin E2 receptors in migration of murine and human breast cancer cells.Q42450323
Chemokine receptor expression in non-melanoma skin cancerQ42525321
A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating propertiesQ42538023
Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.Q42807023
Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.Q42823593
Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cellsQ43006369
Prostaglandin synthesis in human T cells: its partial inhibition by lectins and anti-CD3 antibodies as a possible step in T cell activation.Q43487588
Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1.Q43518303
Epithelial cancer cell migration: a role for chemokine receptors?Q43657321
Adenosine acts through an A3 receptor to prevent the induction of murine anti-CD3-activated killer T cells.Q43981136
Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.Q44001857
Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma and levels of prostaglandin E2 and 15-deoxy-delta12,14-prostaglandin J2 in human breast cancer and metastasisQ44231772
Expression of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1 in human brain tumors and their involvement in glial proliferation in vitroQ44251647
Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells.Q44342291
Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cellsQ44430440
Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors.Q44435157
CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrinQ44635459
Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receQ45003981
Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascadeQ45309112
The effects of prostaglandin A2 on cell growth, cell cycle status and apoptosis induction in HeLa and MCF-7 cells.Q46334228
Characterization of the CXCR4 signaling in pancreatic cancer cellsQ46823256
High molecular weight phospholipase A2 and fatty acids in human colon tumours and associated normal tissueQ47325239
Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomasQ47376060
CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers.Q47853213
Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivoQ47895026
Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcomeQ47917544
CXCR4 is expressed in ductal carcinoma in situ of the breast and in atypical ductal hyperplasiaQ47936188
Rapid mobilization of CD34+ cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple myeloma and non-Hodgkin's lymphomaQ47951335
Nestin, PDGFRbeta, CXCL12 and VEGF in glioma patients: different profiles of (pro-angiogenic) molecule expression are related with tumor grade and may provide prognostic information.Q48115693
CXCR-4, a chemokine receptor, is overexpressed in and required for proliferation of glioblastoma tumor cellsQ48354586
CXCR4 is a major chemokine receptor on glioma cells and mediates their survivalQ48464729
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P304page(s)769413
P577publication date2008-01-01
P1433published inPPAR ResearchQ15756406
P1476titleCXCR4 in Cancer and Its Regulation by PPARgamma
P478volume2008

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