Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51

scientific article published on 6 March 2016

Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51 is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/NEUONC/NOW022
P932PMC publication ID4933483
P698PubMed publication ID26951384
P5875ResearchGate publication ID297661747

P50authorJuan José Martínez-IrujoQ46762838
Naiara Martinez-VélezQ47095339
Marisol Gonzalez-HuarrizQ59684682
Chris JonesQ60537395
Tomas AragonQ73802503
P2093author name stringMarta M Alonso
Frederick F Lang
Candelaria Gomez-Manzano
Juan Fueyo
Miguel Angel Idoate
Beatriz Vera
Enric Xipell
Arlet M Acanda
Antonia García Garzón
P2860cites workThe therapeutic effects of 4-phenylbutyric acid in maintaining proteostasisQ38347258
Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastomaQ39060215
ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51.Q39097758
Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactive oxygen speciesQ39115194
Salinomycin sensitizes antimitotic drugs-treated cancer cells by increasing apoptosis via the prevention of G2 arrestQ39412485
Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death.Q39455351
Salinomycin Effects on Mitochondrial Ion Translocation and RespirationQ39768003
Acquired resistance to combination treatment with temozolomide and ABT-888 is mediated by both base excision repair and homologous recombination DNA repair pathwaysQ39787856
Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell deathQ40016108
P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycinQ40025134
Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomideQ40522471
The activity of yeast Hog1 MAPK is required during endoplasmic reticulum stress induced by tunicamycin exposureQ41192860
Measuring ER Stress and the Unfolded Protein Response Using Mammalian Tissue Culture SystemQ41898554
Association of elevated GRP78 expression with increased astrocytoma malignancy via Akt and ERK pathwaysQ53287003
An implantable guide-screw system for brain tumor studies in small animals.Q55476199
Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independentQ73144195
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That which does not kill me makes me stronger: adapting to chronic ER stressQ81405125
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Endoplasmic reticulum stress in malignancyQ27006434
MGMT gene silencing and benefit from temozolomide in glioblastomaQ27824832
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastomaQ27860910
Identification of selective inhibitors of cancer stem cells by high-throughput screeningQ28255115
Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastomaQ28286168
The Unfolded Protein Response: From Stress Pathway to Homeostatic RegulationQ29547396
Drug combination studies and their synergy quantification using the Chou-Talalay methodQ29617422
ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agentsQ34287713
Inhibition of Mitochondria- and Endoplasmic Reticulum Stress-Mediated Autophagy Augments Temozolomide-Induced Apoptosis in Glioma CellsQ34321143
Current and future developments in the use of temozolomide for the treatment of brain tumoursQ34571908
The Unfolded Protein Response, Degradation from Endoplasmic Reticulum and CancerQ34576070
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.Q34702354
Messenger RNA targeting to endoplasmic reticulum stress signalling sites.Q34903088
Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor-derived cellsQ34977354
Salinomycin induces calpain and cytochrome c-mediated neuronal cell deathQ35202272
Alkylpurine–DNA–N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patientsQ35640624
Recent advances in the treatment of malignant astrocytomaQ36416748
Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenanceQ36892078
GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosisQ36926745
Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells.Q37043022
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPaseQ37726811
Brca2, Rad51 and Mre11: Performing balancing acts on replication forksQ37928803
Complex DNA repair pathways as possible therapeutic targets to overcome temozolomide resistance in glioblastomaQ38066230
Endoplasmic reticulum stress and the unfolded protein response: targeting the Achilles heel of multiple myeloma.Q38111315
The impact of the endoplasmic reticulum protein-folding environment on cancer developmentQ38241996
P433issue8
P921main subjectendoplasmic reticulumQ79927
temozolomideQ425088
P304page(s)1109-1119
P577publication date2016-03-06
P1433published inNeuro-OncologyQ15724471
P1476titleEndoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51
P478volume18

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cites work (P2860)
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