Potential Epigenetic-Based Therapeutic Targets for Glioma

scientific article published on 15 November 2018

Potential Epigenetic-Based Therapeutic Targets for Glioma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FNMOL.2018.00408
P932PMC publication ID6249994
P698PubMed publication ID30498431

P2093author name stringLijuan Wang
Fengyuan Che
Xueyuan Heng
Lanlan Zang
Shukkoor Muhammed Kondengaden
P2860cites workA Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence.Q52593922
Composition and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease.Q52681632
Inhibition of NF-κB results in anti-glioma activity and reduces temozolomide-induced chemoresistance by down-regulating MGMT gene expression.Q52715991
Mutation of HELLS, a chromatin remodeling gene, gastric and colorectal cancers.Q54187067
Whole-exome sequencing reveals potential molecular predictors of relapse after discontinuation of the targeted therapy in chronic myeloid leukemia patients.Q54222671
Ionizing radiation-inducible miR-30e promotes glioma cell invasion through EGFR stabilization by directly targeting CBL-B.Q54289713
Prognostic relevance of SOCS3 hypermethylation in patients with glioblastoma multiforme.Q54517221
Immunotherapy With Human Gamma Delta T Cells-Synergistic Potential of Epigenetic Drugs?Q55030400
Loss of 5hmC identifies a new type of aberrant DNA hypermethylation in glioma.Q55456885
miR-145 inhibits migration and invasion of glioma stem cells by targeting ABCG2.Q55460959
MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin.Q55461065
MicroRNA-125b-2 confers human glioblastoma stem cells resistance to temozolomide through the mitochondrial pathway of apoptosis.Q55462882
Phase I trial of plerixafor combined with decitabine in newly diagnosed older patients with acute myeloid leukemia.Q64915559
Most methylation-susceptible DNA sequences in human embryonic stem cells undergo a change in conformation or flexibility upon methylationQ85977394
DNA methylation patterns and epigenetic memoryQ22065780
Functional analysis of the subunits of the chromatin assembly factor RSFQ24322794
Histone deacetylases (HDACs): characterization of the classical HDAC familyQ24535587
Identification of a CpG island methylator phenotype that defines a distinct subgroup of gliomaQ24612429
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1Q24651548
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivoQ24657924
Visualizing epigenetics: current advances and advantages in HDAC PET imaging techniquesQ26862755
Gene methylation in gastric cancerQ26991766
SWI/SNF chromatin remodeling complexes and cancerQ26998657
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294Q27653816
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agentsQ27777800
MGMT gene silencing and benefit from temozolomide in glioblastomaQ27824832
The prognostic IDH1( R132 ) mutation is associated with reduced NADP+-dependent IDH activity in glioblastomaQ27851550
EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma.Q48945472
Concerted action of histone methyltransferases G9a and PRMT-1 regulates PGC-1α-RIG-I axis in IFNγ treated glioma cellsQ49056915
Mutation analysis of DKK1 and in vivo evidence of predominant p53-independent DKK1 function in gliomasQ49116936
Phase II Study of Bevacizumab and Vorinostat for Patients with Recurrent World Health Organization Grade 4 Malignant Glioma.Q50042687
Models of Epigenetic Age Capture Patterns of DNA Methylation in Glioma Associated with Molecular Subtype, Survival, and Recurrence.Q50047153
Phase I/II Trial of Combination of Temozolomide Chemotherapy and Immunotherapy With Fusions of Dendritic and Glioma Cells in Patients With Glioblastoma.Q50220589
Initial testing (stage 1) of tazemetostat (EPZ-6438), a novel EZH2 inhibitor, by the Pediatric Preclinical Testing Program.Q50324483
Down-expression of miR-373 predicts poor prognosis of glioma and could be a potential therapeutic target.Q50583627
miR-152 regulated glioma cell proliferation and apoptosis via Runx2 mediated by DNMT1.Q50594880
MiR-181b modulates EGFR-dependent VCAM-1 expression and monocyte adhesion in glioblastoma.Q50894719
Phase I study of 5-aza-2'-deoxycytidine in combination with valproic acid in non-small-cell lung cancer.Q50933613
SAHA-based novel HDAC inhibitor design by core hopping method.Q51051882
Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity.Q51219859
Sodium Selenite Decreased HDAC Activity, Cell Proliferation and Induced Apoptosis in Three Human Glioblastoma Cells.Q52151062
DNA methylation in human epigenomes depends on local topology of CpG sitesQ37021507
Comparative Brain and Central Nervous System Tumor Incidence and Survival between the United States and Taiwan Based on Population-Based RegistryQ37112417
Role of cytosolic NADP+-dependent isocitrate dehydrogenase in ischemia-reperfusion injury in mouse kidneyQ37138815
MiR-145 functions as a tumor-suppressive RNA by targeting Sox9 and adducin 3 in human glioma cellsQ37187706
Valproic Acid and Other HDAC Inhibitors Upregulate FGF21 Gene Expression and Promote Process Elongation in Glia by Inhibiting HDAC2 and 3Q37220495
miR-101 inhibits glioma cell invasion via the downregulation of COX-2.Q37288437
HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activityQ37294988
Long Non-coding RNA TUSC7, a Target of miR-23b, Plays Tumor-Suppressing Roles in Human GliomasQ37314044
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.Q37432733
Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and gliomaQ37475389
Molecular-targeted therapy in malignant melanomaQ37483949
A phase I study of vorinostat in combination with bortezomib in patients with advanced malignanciesQ37512730
Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2.Q37533362
Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3β-E2F1 Axis Linking Reversely with Survival in GliomasQ37541852
An Insight into the Increasing Role of LncRNAs in the Pathogenesis of GliomasQ37670401
DNA Methylation Targeting: The DNMT/HMT Crosstalk ChallengeQ37729405
The DNMT3 family of mammalian de novo DNA methyltransferasesQ37867205
Metabolism of glioma and IDH1/IDH2 mutationsQ37925261
MicroRNAs in islet immunobiology and transplantationQ38163421
Epigenetic dysregulation in glioma.Q38213062
Assessing MGMT methylation status and its current impact on treatment in glioblastoma.Q38317424
Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells.Q38340158
Down-regulation of miR-124 target protein SCP-1 inhibits neuroglioma cell migrationQ38713163
Knockdown of HDAC1 expression suppresses invasion and induces apoptosis in glioma cellsQ38720882
Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.Q38725573
Mechanism of G9a inhibitor BIX‑01294 acting on U251 glioma cellsQ38737468
PTP4A3 is a target for inhibition of cell proliferatin, migration and invasion through Akt/mTOR signaling pathway in glioblastoma under the regulation of miR-137.Q38763008
MiR-153 as a Tumor Suppressor in Glioblastoma Multiforme is Downregulated by DNA Methylation.Q38769127
No Significant Cytotoxic Effect of the EZH2 Inhibitor Tazemetostat (EPZ-6438) on Pediatric Glioma Cells with Wildtype Histone 3 or Mutated Histone 3.3.Q38773933
MiR-424 functions as a tumor suppressor in glioma cells and is down-regulated by DNA methylationQ38784189
MiR-218 inhibits the tumorgenesis and proliferation of glioma cells by targeting Robo1.Q38793204
miR-373 Inhibits Glioma Cell U251 Migration and Invasion by Down-Regulating CD44 and TGFBR2.Q38795514
Downregulation of miR-195 via cyclosporin A in human glioblastoma cellsQ38822022
miR-124 suppresses the migration and invasion of glioma cells in vitro via Capn4.Q38822348
Regulation of IL-8 gene expression in gliomas by microRNA miR-93.Q38829417
The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death.Q38834894
Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via Krüppel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludinQ38836349
MiR-873 acts as a novel sensitizer of glioma cells to cisplatin by targeting Bcl-2.Q38839310
MiR-218 Inhibited Growth and Metabolism of Human Glioblastoma Cells by Directly Targeting E2F2.Q38870748
miR-20a mediates temozolomide-resistance in glioblastoma cells via negatively regulating LRIG1 expressionQ38876901
MiR-221/222 promote human glioma cell invasion and angiogenesis by targeting TIMP2.Q38904607
Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant gliomaQ38912327
Downregulation of HTATIP2 expression is associated with promoter methylation and poor prognosis in gliomaQ38916900
Inhibition of HDAC increases the senescence induced by natural polyphenols in glioma cellsQ38970906
MiR-15b targets cyclin D1 to regulate proliferation and apoptosis in glioma cellsQ38978071
MAGED4 expression in glioma and upregulation in glioma cell lines with 5-aza-2'-deoxycytidine treatmentQ38990776
Oncogenic miR-20a and miR-106a enhance the invasiveness of human glioma stem cells by directly targeting TIMP-2.Q39007403
miR-7 inhibits glioblastoma growth by simultaneously interfering with the PI3K/ATK and Raf/MEK/ERK pathwaysQ39017914
PCDH10 is required for the tumorigenicity of glioblastoma cellsQ39035983
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastomaQ27860910
MicroRNAs: genomics, biogenesis, mechanism, and functionQ27861070
Post-translational modifications regulate class IIa histone deacetylase (HDAC) function in health and diseaseQ28088517
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancersQ28115840
Suppression of miR-184 in malignant gliomas upregulates SND1 and promotes tumor aggressivenessQ28247786
Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytomaQ28269109
De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid culturesQ28277249
Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drugQ28282479
RSF governs silent chromatin formation via histone H2Av replacementQ28472344
MiR-15b and miR-152 reduce glioma cell invasion and angiogenesis via NRP-2 and MMP-3Q28564217
Functions of DNA methylation: islands, start sites, gene bodies and beyondQ29547260
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastomaQ29616862
Phase II study of panobinostat in combination with bevacizumab for recurrent glioblastoma and anaplastic gliomaQ30300986
miR-873 suppresses H9C2 cardiomyocyte proliferation by targeting GLI1.Q33292456
Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomasQ33361466
Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group studyQ33383828
Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiformeQ33387317
Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children's Oncology Group phase I consortium reportQ33390536
Phase I study of vorinostat in combination with temozolomide in patients with high-grade gliomas: North American Brain Tumor Consortium Study 04-03.Q33402978
A pediatric phase 1 trial of vorinostat and temozolomide in relapsed or refractory primary brain or spinal cord tumors: a Children's Oncology Group phase 1 consortium studyQ33406813
A mutation in the mouse Chd2 chromatin remodeling enzyme results in a complex renal phenotypeQ33637832
Low-dose decitabine-based chemoimmunotherapy for patients with refractory advanced solid tumors: a phase I/II reportQ33744733
Slit2/Robo1 signaling in glioma migration and invasionQ34152186
Chromatin-modifying drugs induce miRNA-153 expression to suppress Irs-2 in glioblastoma cell linesQ34157966
Prognostic prediction of glioblastoma by quantitative assessment of the methylation status of the entire MGMT promoter regionQ34168829
Phase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant gliomaQ34208293
Epigenomic alterations define lethal CIMP-positive ependymomas of infancyQ34240198
Down-regulation of neogenin accelerated glioma progression through promoter Methylation and its overexpression in SHG-44 Induced ApoptosisQ34292791
Rsf-1, a chromatin remodeling protein, induces DNA damage and promotes genomic instability.Q34352173
Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastomaQ34381578
Novel insights into DNA methylation features in spermatozoa: stability and peculiaritiesQ34446771
Insulator dysfunction and oncogene activation in IDH mutant gliomasQ34506441
Genome-wide methylation profiling identifies an essential role of reactive oxygen species in pediatric glioblastoma multiforme and validates a methylome specific for H3 histone family 3A with absence of G-CIMP/isocitrate dehydrogenase 1 mutation.Q34511715
Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant gliomaQ34544319
DNA hypermethylation and aberrant expression of the EMP3 gene at 19q13.3 in Human GliomasQ34645950
miR-125b inhibits Connexin43 and promotes glioma growthQ39094461
TFAM is directly regulated by miR-23b in gliomaQ39100619
Cytostatic and apoptotic effects of DNMT and HDAC inhibitors in endometrial cancer cellsQ39120070
Deletion of the Polycomb-Group Protein EZH2 Leads to Compromised Self-Renewal and Differentiation Defects in Human Embryonic Stem Cells.Q39123593
Epigenetic Targeted Therapy for Diffuse Intrinsic Pontine GliomaQ39154575
The Chromatin Assembly Factor Complex 1 (CAF1) and 5-Azacytidine (5-AzaC) Affect Cell Motility in Src-transformed Human Epithelial Cells.Q39166548
Poly(amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cellsQ39195279
MIR-137 suppresses growth and invasion, is downregulated in oligodendroglial tumors and targets CSE1L.Q39223766
MiR-16-1 plays a role in reducing migration and invasion of glioma cells.Q39240322
Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasivenessQ39266398
MiR-296-3p regulates cell growth and multi-drug resistance of human glioblastoma by targeting ether-à-go-go (EAG1).Q39274181
Co-inhibition of microRNA-10b and microRNA-21 exerts synergistic inhibition on the proliferation and invasion of human glioma cellsQ39319105
MiR-410 regulates MET to influence the proliferation and invasion of gliomaQ39322020
Epigenetic modulation in cancer immunotherapyQ39369845
MiR-483-5p suppresses the proliferation of glioma cells via directly targeting ERK1.Q39371347
miR-221/222 is the regulator of Cx43 expression in human glioblastoma cellsQ39403463
Human miR-31 targets radixin and inhibits migration and invasion of glioma cellsQ39442069
A phase I/II study of decitabine in combination with panitumumab in patients with wild-type (wt) KRAS metastatic colorectal cancerQ39450048
RUNX3 expression is lost in glioma and its restoration causes drastic suppression of tumor invasion and migrationQ39472960
Knockdown of TFPI-2 promotes migration and invasion of glioma cellsQ39550861
Aberrant CpG island hypermethylation and down-regulation of Oct-6 mRNA expression in human hepatocellular carcinomaQ39568502
Downregulation of Spry2 by miR-21 triggers malignancy in human gliomasQ39600647
miR-124a is frequently down-regulated in glioblastoma and is involved in migration and invasion.Q39613292
MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8Q39642605
Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesisQ39642619
MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2.Q39732104
Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cellsQ39745087
Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma.Q39752244
Frequent promoter hypermethylation of Wnt pathway inhibitor genes in malignant astrocytic gliomasQ39784672
Synergistic induction of NY-ESO-1 antigen expression by a novel histone deacetylase inhibitor, valproic acid, with 5-aza-2'-deoxycytidine in glioma cellsQ39912679
Hypermethylation of the RASSF1A gene in gliomas.Q40477489
Epigenetic inactivation of RASSF1A candidate tumor suppressor gene at 3p21.3 in brain tumorsQ40621367
Methylation of the p73 gene in gliomasQ40708036
NDRG2 and NDRG4 Expression Is Altered in Glioblastoma and Influences Survival in Patients with MGMT-methylated TumorsQ40853627
Regulation of human glioma cell apoptosis and invasion by miR-152-3p through targeting DNMT1 and regulating NF2 : MiR-152-3p regulate glioma cell apoptosis and invasionQ41206487
Impact on prognosis of the regional distribution of MGMT methylation with respect to the CpG island methylator phenotype and age in glioma patients.Q41435886
Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51Q42014579
Structure based design, synthesis and activity studies of small hybrid molecules as HDAC and G9a dual inhibitorsQ42064958
Blocking of the interaction between Wnt proteins and their co-receptors contributes to the anti-tumor effects of adenovirus-mediated DKK3 in glioblastomaQ42183976
MicroRNA‑21 promotes migration and invasion of glioma cells via activation of Sox2 and β‑catenin signaling.Q42315668
Gross total but not incomplete resection of glioblastoma prolongs survival in the era of radiochemotherapyQ42623558
Phase I/II Trial of Vorinostat Combined with Temozolomide and Radiation Therapy for Newly Diagnosed Glioblastoma: Final Results of Alliance N0874/ABTC 02.Q42696115
Assessing the MGMT status in glioblastoma: one step forward, two steps back?Q43242881
MiR-195, miR-196b, miR-181c, miR-21 expression levels and O-6-methylguanine-DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patientsQ44273844
The role of DNA methylation in setting up chromatin structure during developmentQ44436568
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignanciesQ44646952
Impact of Natural Compounds on DNA Methylation Levels of the Tumor Suppressor Gene RASSF1A in CancerQ45814721
Growth inhibitory effect on glioma cells of adenovirus-mediated p16/INK4a gene transfer in vitro and in vivoQ45871582
Molecular Pathways: At the Crossroads of Cancer Epigenetics and ImmunotherapyQ46047090
The RNA methyltransferase Dnmt2 methylates DNA in the structural context of a tRNA.Q46057425
A General Non-Radioactive ATPase Assay for Chromatin Remodeling ComplexesQ46196399
Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine gliomaQ47151280
PRMT5 as a druggable target for glioblastoma therapy.Q47437818
Glioma CpG Island Methylator Phenotype (G-CIMP): Biological and Clinical ImplicationsQ47894744
EZH2 Palmitoylation Mediated by ZDHHC5 in p53-Mutant Glioma Drives Malignant Development and ProgressionQ47992918
Epigenetic inactivation of the hMLH1 gene in progression of gliomasQ48156262
Aberrant hypermethylation of p14ARF and O6-methylguanine-DNA methyltransferase genes in astrocytoma progressionQ48173093
miR-34a attenuates glioma cells progression and chemoresistance via targeting PD-L1.Q48189611
HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growthQ48227278
Associations between TFPI-2 methylation and poor prognosis in glioblastomasQ48351776
2016 World Health Organization Classification of Central Nervous System TumorsQ48508591
Long non-coding RNA TUG1 acts as a miR-26a sponge in human glioma cellsQ48647907
Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumorsQ48718306
CGCG clinical practice guidelines for the management of adult diffuse gliomasQ48843889
Decreased miRNA-146a in glioblastoma multiforme and regulation of cell proliferation and apoptosis by target Notch1.Q48877188
Phase I trial of panobinostat and fractionated stereotactic re-irradiation therapy for recurrent high grade gliomas.Q48943751
Phase 1 study of valproic acid in pediatric patients with refractory solid or CNS tumors: a children's oncology group reportQ34722045
Downregulation of TES by hypermethylation in glioblastoma reduces cell apoptosis and predicts poor clinical outcomeQ34787109
MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells.Q34819445
Targeting the SMO oncogene by miR-326 inhibits glioma biological behaviors and stemnessQ34886908
A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03.Q34977381
Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivoQ34979824
miR-221/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTPμQ34988052
DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell linesQ35098017
Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolinesQ35209782
Promoter methylation and downregulation of SLC22A18 are associated with the development and progression of human gliomaQ35252433
Upregulation of miR-184 enhances the malignant biological behavior of human glioma cell line A172 by targeting FIH-1.Q35296213
CAMTA1 is a novel tumour suppressor regulated by miR-9/9* in glioblastoma stem cellsQ35422357
Constitutional tandem duplication of 9q34 that truncates EHMT1 in a child with gangliogliomaQ35448951
Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potentialQ35589633
A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With GlioblastomaQ35701142
MicroRNAome genome: a treasure for cancer diagnosis and therapy.Q35704188
MicroRNA-195 plays a tumor-suppressor role in human glioblastoma cells by targeting signaling pathways involved in cellular proliferation and invasionQ35760644
Deletion or epigenetic silencing of AJAP1 on 1p36 in glioblastomaQ35783190
The emerging role of NG2 in pediatric diffuse intrinsic pontine gliomaQ35828522
Discovery of novel small molecule inhibitors of lysine methyltransferase G9a and their mechanism in leukemia cell linesQ36072085
RANK (TNFRSF11A) is epigenetically inactivated and induces apoptosis in gliomasQ36088188
High level of miR-221/222 confers increased cell invasion and poor prognosis in gliomaQ36112656
Selective increase in subtelomeric DNA methylation: an epigenetic biomarker for malignant gliomaQ36135415
Low MiR-149 expression is associated with unfavorable prognosis and enhanced Akt/mTOR signaling in gliomaQ36261690
A phase I trial of vorinostat and bortezomib in children with refractory or recurrent solid tumors: a Children's Oncology Group phase I consortium study (ADVL0916)Q36438027
miR-128 regulates the apoptosis and proliferation of glioma cells by targeting RhoEQ36502836
Molecular-targeted therapy for elderly patients with advanced non-small cell lung cancerQ36502935
Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.Q36606033
HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven MedulloblastomaQ36694288
MiR-218 sensitizes glioma cells to apoptosis and inhibits tumorigenicity by regulating ECOP-mediated suppression of NF-κB activityQ36713464
MiR-138 exerts anti-glioma efficacy by targeting immune checkpointsQ36785139
Wnt pathway antagonists, SFRP1, SFRP2, SOX17, and PPP2R2B, are methylated in gliomas and SFRP1 methylation predicts shorter survival.Q36795811
Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomasQ36953248
Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor GrowthQ36963419
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectmolecular biologyQ7202
P304page(s)408
P577publication date2018-11-15
P1433published inFrontiers in Molecular NeuroscienceQ27721913
P1476titlePotential Epigenetic-Based Therapeutic Targets for Glioma
P478volume11

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Q90401711Specific Glioma Prognostic Subtype Distinctions Based on DNA Methylation Patterns
Q90682138Systematic Profiling of Alternative mRNA Splicing Signature for Predicting Glioblastoma Prognosis

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