Pharmacodynamics, pharmacokinetics, and safety of ticagrelor in Chinese patients with stable coronary artery disease

scientific article published on April 2016

Pharmacodynamics, pharmacokinetics, and safety of ticagrelor in Chinese patients with stable coronary artery disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/BCP.12950
P932PMC publication ID4972151
P698PubMed publication ID27038001

P50authorJingchuan GuoQ49794743
P2093author name stringHaiyan Li
Glenn F Carlson
Renli Teng
P2860cites workPersonalized antiplatelet and anticoagulation therapy: applications and significance of pharmacogenomicsQ26822796
Ticagrelor: Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Profile: An UpdateQ27006031
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Ticagrelor versus clopidogrel in patients with acute coronary syndromesQ29619002
Determination of ticagrelor and two metabolites in plasma samples by liquid chromatography and mass spectrometryQ33447413
Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteersQ34019342
Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study.Q34020220
Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND studyQ34021458
Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjectsQ34120974
Platelet function tests: a comparative reviewQ35121464
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Polymorphism of human cytochrome P450 enzymes and its clinical impactQ37514326
Ticagrelor: the first reversibly binding oral P2Y12 receptor antagonistQ37552005
Evaluating the risk-benefit profile of the direct-acting P2Y(12) inhibitor ticagrelor in acute coronary syndromesQ37959155
Cytochrome P450 variations in different ethnic populationsQ37979866
Racial/ethnic differences in drug disposition and response: review of recently approved drugsQ38351175
Pharmacokinetics and tolerability of single and multiple doses of ticagrelor in healthy Chinese subjects: an open-label, sequential, two-cohort, single-centre studyQ38479485
Long-term use of ticagrelor in patients with prior myocardial infarctionQ40263764
Inhibitory effects of ticagrelor compared with clopidogrel on platelet function in patients with acute coronary syndromes: the PLATO (PLATelet inhibition and patient Outcomes) PLATELET substudyQ42910350
Pharmacokinetics, pharmacodynamics, tolerability and safety of single ascending doses of ticagrelor, a reversibly binding oral P2Y(12) receptor antagonist, in healthy subjectsQ43187673
Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation.Q45954831
Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1.Q46707933
Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome: primary results of the DISPERSEQ46916592
In vitro evaluation of potential drug-drug interactions with ticagrelor: cytochrome P450 reaction phenotyping, inhibition, induction, and differential kineticsQ48302970
Pharmacodynamics, pharmacokinetics and safety of ticagrelor in Asian patients with stable coronary artery disease.Q50468521
Platelet function testing in acute cardiac care - is there a role for prediction or prevention of stent thrombosis and bleeding?Q53388110
Systematic screening for polymorphisms in the CYP3A4 gene in the Chinese population.Q54580627
Are P2Y12 reaction unit (PRU) and % inhibition index equivalent for the expression of P2Y12 inhibition by the VerifyNow assay? Role of haematocrit and haemoglobin levels.Q54790334
[Guideline for diagnosis and treatment of patients with chronic stable angina (no abstract)]Q80507634
Pharmacokinetics, Pharmacodynamics, and Safety of Ticagrelor in Volunteers With Mild Hepatic ImpairmentQ85167435
Pharmacokinetics, pharmacodynamics, and tolerability of single and multiple doses of ticagrelor in Japanese and Caucasian volunteersQ87730194
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectpharmacokineticsQ323936
pharmacodynamicsQ725307
P304page(s)352-361
P577publication date2016-04-01
P1433published inBritish Journal of Clinical PharmacologyQ176044
P1476titlePharmacodynamics, pharmacokinetics, and safety of ticagrelor in Chinese patients with stable coronary artery disease
P478volume82