Deletion of the signalling molecule synthase ScbA has pleiotropic effects on secondary metabolite biosynthesis, morphological differentiation and primary metabolism in Streptomyces coelicolor A3(2)

scientific article published on 8 December 2010

Deletion of the signalling molecule synthase ScbA has pleiotropic effects on secondary metabolite biosynthesis, morphological differentiation and primary metabolism in Streptomyces coelicolor A3(2) is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1751-7915.2010.00232.X
P953full work available at URLhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1751-7915.2010.00232.x
P932PMC publication ID3818864
P698PubMed publication ID21342469
P5875ResearchGate publication ID49856389

P7228access restriction statusopen accessQ232932
P50authorRainer BreitlingQ38305239
Eriko TakanoQ39657894
P2093author name stringKay Nieselt
Wei-Shou Hu
Daniela Eggle
Davide D'Alia
P2860cites workGenome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350Q24650517
Bacterial small-molecule signaling pathwaysQ24657011
Purification and structural determination of SCB1, a gamma-butyrolactone that elicits antibiotic production in Streptomyces coelicolor A3(2)Q28375889
Involvement of SigT and RstA in the differentiation of Streptomyces coelicolorQ28504064
BldG and SCO3548 interact antagonistically to control key developmental processes in Streptomyces coelicolorQ28504086
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)Q29547307
Genetic and transcriptional analysis of absA, an antibiotic gene cluster-linked two-component system that regulates multiple antibiotics in Streptomyces coelicolorQ31906918
The dynamic architecture of the metabolic switch in Streptomyces coelicolor.Q33522311
A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseusQ34775777
Noncoding RNA of glutamine synthetase I modulates antibiotic production in Streptomyces coelicolor A3(2).Q35016286
Engineering of primary carbohydrate metabolism for increased production of actinorhodin in Streptomyces coelicolorQ35129974
AfsR as an integrator of signals that are sensed by multiple serine/threonine kinases in Streptomyces coelicolor A3(2).Q35186294
Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces.Q35844627
Control of tylosin biosynthesis in Streptomyces fradiae.Q37292992
The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor.Q37388902
ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and is able to synthesize -butyrolactonesQ56879474
Mutants blocked in streptomycin production in Streptomyces griseus - the role of A-factorQ71601744
The A-factor, responsible for streptomycin biosynthesis by mutant strains of Actinomyces streptomyciniQ71985493
Expression of the Csp protein family upon cold shock and production of tetracycline in Streptomyces aureofaciensQ73175376
Enhancement of kasugamycin production by pH shock in batch cultures of Streptomyces kasugaensisQ74138491
Actinorhodin production by Streptomyces coelicolor A3(2) in iron-restricted mediaQ77300055
Proteins encoded by the conservon of Streptomyces coelicolor A3(2) comprise a membrane-associated heterocomplex that resembles eukaryotic G protein-coupled regulatory systemQ79327901
LuxR-family 'solos': bachelor sensors/regulators of signalling moleculesQ37454006
Reciprocal regulation between SigK and differentiation programs in Streptomyces coelicolorQ37481398
Molecular mechanisms of compounds affecting bacterial biofilm formation and dispersal.Q37694372
Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in StreptomycesQ37715314
Engineering of primary carbon metabolism for improved antibiotic production in Streptomyces lividansQ39648780
Mycelium differentiation and antibiotic production in submerged cultures of Streptomyces coelicolorQ39753216
Environmental signals triggering methylenomycin production by Streptomyces coelicolor A3(2).Q39847018
A novel class of secreted hydrophobic proteins is involved in aerial hyphae formation in Streptomyces coelicolor by forming amyloid-like fibrilsQ39895836
DevA, a GntR-like transcriptional regulator required for development in Streptomyces coelicolor.Q42575928
Identification of an AfsA homologue (BarX) from Streptomyces virginiae as a pleiotropic regulator controlling autoregulator biosynthesis, virginiamycin biosynthesis and virginiamycin M1 resistanceQ42625433
Cloning, heterologous expression and purification of an isocitrate lyase from Streptomyces clavuligerus NRRL 3585.Q42665624
afsR2: a previously undetected gene encoding a 63-amino-acid protein that stimulates antibiotic production in Streptomyces lividansQ42691800
Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2).Q43071552
The role of absC, a novel regulatory gene for secondary metabolism, in zinc-dependent antibiotic production in Streptomyces coelicolor A3(2).Q43244311
Null mutation analysis of an afsA-family gene, barX, that is involved in biosynthesis of the {gamma}-butyrolactone autoregulator in Streptomyces virginiaeQ43271790
Analysis of two additional signaling molecules in Streptomyces coelicolor and the development of a butyrolactone-specific reporter systemQ43271838
Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymesQ43713841
A complex role for the gamma-butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2).Q43736205
Cloning of the conserved regulatory operon by its aerial mycelium-inducing activity in an amfR mutant of Streptomyces griseusQ44376336
The promoter of a cold-shock-like gene has pleiotropic effects on Streptomyces antibiotic biosynthesisQ44387136
Disruption of sabR affects nikkomycin biosynthesis and morphogenesis in Streptomyces ansochromogenesQ44627365
Differential production of two antibiotics of Streptomyces coelicolor A3(2), actinorhodin and undecylprodigiosin, upon salt stress conditionsQ44822577
Multiple pathways for acetate assimilation in Streptomyces cinnamonensisQ44913854
Identification of a cluster of genes that directs desferrioxamine biosynthesis in Streptomyces coelicolor M145.Q45188178
DNA microarray analysis of global gene regulation by A-factor in Streptomyces griseus.Q46038862
A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolorQ46424889
Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerusQ46429005
Cloning and in vivo functional analysis by disruption of a gene encoding the gamma-butyrolactone autoregulator receptor from Streptomyces natalensisQ46755926
The Streptomyces coelicolor GlnR regulon: identification of new GlnR targets and evidence for a central role of GlnR in nitrogen metabolism in actinomycetesQ46819701
Dissecting the component reactions catalyzed by the actinorhodin minimal polyketide synthase.Q46885569
Discovery of a new peptide natural product by Streptomyces coelicolor genome miningQ46891015
NepA is a structural cell wall protein involved in maintenance of spore dormancy in Streptomyces coelicolor.Q51816902
P4510describes a project that useslimmaQ112236343
P433issue2
P921main subjectdeferoxamineQ419618
secondary metaboliteQ522244
pleiotropyQ1134884
StreptomycesQ1144013
Streptomyces avermitilisQ1946562
Streptomyces coelicolorQ2355919
actinorhodineQ4676996
Streptomyces albidoflavusQ22286833
Streptomyces albusQ7623378
Streptomyces griseusQ7623385
Streptomyces parvulusQ26291671
Streptomyces pilosusQ26291829
Streptomyces violaceoruberQ26293287
Streptomyces anthocyanicusQ22286907
Streptomyces chartreusisQ22287085
Streptomyces hebeiensisQ22665886
Streptomyces hiroshimensisQ22665893
Streptomyces lydicusQ26291044
Streptomyces werraensisQ26293473
Streptomyces xinghaiensisQ26293545
Bis-1,2-{[(Z)-2carboxy-2-methyl-1,3-dioxane]-5-yloxycarbonyl}-piperazineQ105013122
(2Z,5Z)-3-methoxy-5-pyrrol-2-ylidene-2-[(5-undecyl-1H-pyrrol-2-yl)methylidene]pyrroleQ105029113
undecylprodigiosinQ105119472
Streptomyces lividansQ68792845
Streptomyces bingchenggensisQ103817234
Streptomyces malaysienseQ104095570
Streptomyces argillaceusQ104096702
Streptomyces wadayamensisQ104917214
Streptomyces refuineusQ105004259
P6954online access statusopen accessQ232932
P304page(s)239-251
P577publication date2010-12-08
P1433published inMicrobial BiotechnologyQ15766695
P1476titleDeletion of the signalling molecule synthase ScbA has pleiotropic effects on secondary metabolite biosynthesis, morphological differentiation and primary metabolism in Streptomyces coelicolor A3(2)
P478volume4

Reverse relations

cites work (P2860)
Q54353911A novel role of 'pseudo'γ-butyrolactone receptors in controlling γ-butyrolactone biosynthesis in Streptomyces.
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Q57979653Analysis of Streptomyces ghanaensis ATCC14672 gene SSFG_07725 for putative γ-butyrolactone synthase
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Q41784290Directed evolution, natural products for cancer chemotherapy, and micro-biosensing robots
Q42177167Diverse control of metabolism and other cellular processes in Streptomyces coelicolor by the PhoP transcription factor: genome-wide identification of in vivo targets.
Q41840399Engineering of N-acetylglucosamine metabolism for improved antibiotic production in Streptomyces coelicolor A3(2) and an unsuspected role of NagA in glucosamine metabolism
Q36328529In conditions of over-expression, WblI, a WhiB-like transcriptional regulator, has a positive impact on the weak antibiotic production of Streptomyces lividans TK24
Q46237083Molecular characterization of a Rhodococcus jostii RHA1 γ-butyrolactone(-like) signalling molecule and its main biosynthesis gene gblA.
Q36667387Molecular regulation of antibiotic biosynthesis in streptomyces.
Q93092649Multi-level regulation of coelimycin synthesis in Streptomyces coelicolor A3(2)
Q42248917Plasticity of Streptomyces coelicolor Membrane Composition Under Different Growth Conditions and During Development.
Q27015037Signals and regulators that govern Streptomyces development
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Q38134377The TetR family of regulators
Q38101244Towards a new science of secondary metabolism
Q38125903Triggers and cues that activate antibiotic production by actinomycetes

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