Talin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations

scientific article published on 25 September 2014

Talin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PROT.24540
P932PMC publication ID5156318
P698PubMed publication ID24677266
P5875ResearchGate publication ID261188577

P50authorMarta FilizolaQ41045386
P2093author name stringAna Negri
Barry S Coller
Davide Provasi
P2860cites workDetermination of the Border between the Transmembrane and Cytoplasmic Domains of Human Integrin SubunitsQ57083866
The inner world of cell adhesion: integrin cytoplasmic domainsQ75293376
The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signallingQ24320948
Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effectsQ24657848
A specific interface between integrin transmembrane helices and affinity for ligandQ24793060
A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic faceQ27639651
Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micellesQ27649993
Structure of the Integrin  IIb Transmembrane SegmentQ27650343
Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied ForcesQ27653293
The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.Q27657634
Structure of an integrin  IIb 3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activationQ27657684
NMR analysis of the αIIbβ3 cytoplasmic interaction suggests a mechanism for integrin regulationQ27666309
All-atom empirical potential for molecular modeling and dynamics studies of proteinsQ27860468
Integrins: bidirectional, allosteric signaling machinesQ27860700
The phosphotyrosine binding-like domain of talin activates integrinsQ28212748
Kindlin-3 is essential for integrin activation and platelet aggregationQ28595084
Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulationsQ29547631
Structural basis of integrin regulation and signalingQ29617618
Prediction of membrane protein structures with complex topologies using limited constraintsQ30374712
Determination of N- and C-terminal borders of the transmembrane domain of integrin subunitsQ33199390
The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bendQ33381441
Recreation of the terminal events in physiological integrin activationQ33616477
A push-pull mechanism for regulating integrin functionQ33817633
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.Q33928601
The final steps of integrin activation: the end gameQ34106011
Kindlins, Integrin Activation and the Regulation of Talin Recruitment to αIIbβ3Q34212141
Tests of Integrin Transmembrane Domain Homo-oligomerization during Integrin Ligand Binding and SignalingQ34503113
Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helicesQ35034161
Multiscale simulations suggest a mechanism for integrin inside-out activationQ35123059
Intact αIIbβ3 Integrin Is Extended after Activation as Measured by Solution X-ray Scattering and Electron MicroscopyQ35266840
Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment.Q35735180
Talin activates integrins by altering the topology of the β transmembrane domainQ36002154
Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signalingQ36007725
Toward high-resolution prediction and design of transmembrane helical protein structuresQ36023705
Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activationQ37187555
On the activation of integrin αIIbβ3: outside-in and inside-out pathwaysQ37204375
Molecular mechanism of inside‐out integrin regulationQ37903927
Integrin bi‐directional signaling across the plasma membraneQ38024314
The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3.Q41543290
Integrin αIIbβ3 inside-out activation: an in situ conformational analysis reveals a new mechanismQ41952463
The structure of the talin/integrin complex at a lipid bilayer: an NMR and MD simulation studyQ42588609
Simulaid: A simulation facilitator and analysis programQ42925390
Breaking the integrin hinge. A defined structural constraint regulates integrin signalingQ43482152
Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signalingQ44136286
Bidirectional transmembrane signaling by cytoplasmic domain separation in integrinsQ44590985
Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity stateQ45182918
Computational design of peptides that target transmembrane helicesQ51035378
TRAJELIX: a computational tool for the geometric characterization of protein helices during molecular dynamics simulationsQ51939563
Anton, a special-purpose machine for molecular dynamics simulationQ56019494
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)3231-3240
P577publication date2014-09-25
P1433published inProteinsQ7251514
P1476titleTalin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations
P478volume82

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cites work (P2860)
Q37369037A model for cyclic mechanical reinforcement
Q64245553Emerging Diversity in Lipid-Protein Interactions
Q92020137Kindlin Is Mechanosensitive: Force-Induced Conformational Switch Mediates Cross-Talk among Integrins
Q46703119Mechanisms of integrin and filamin binding and their interplay with talin during early focal adhesion formation
Q51347457No genetic abnormalities identified in α2IIb and β3: phenotype overcomes genotype in Glanzmann thrombasthenia
Q52365137Regulation of inside-out β1-integrin activation by CDCP1.
Q39552692The Integrin Receptor in Biologically Relevant Bilayers: Insights from Molecular Dynamics Simulations.
Q41271593The dual structural roles of the membrane distal region of the α-integrin cytoplasmic tail during integrin inside-out activation
Q90389303[Special type of Glanzmann's thrombasthenia]
Q58122368[The progresses in research and treatment of inherited platelet disorders]
Q46767135α-Actinin Induces a Kink in the Transmembrane Domain of β3-Integrin and Impairs Activation via Talin
Q33421611αIIbβ3 variants defined by next-generation sequencing: predicting variants likely to cause Glanzmann thrombasthenia
Q36955873αIIbβ3: structure and function

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