Priming the pancreatic cancer tumor microenvironment for checkpoint-inhibitor immunotherapy

scientific article published on November 2014

Priming the pancreatic cancer tumor microenvironment for checkpoint-inhibitor immunotherapy is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4161/21624011.2014.962401
P932PMC publication ID4292514
P698PubMed publication ID25941589

P50authorElizabeth JaffeeQ29452184
Lei ZhengQ59833013
P2093author name stringEric R Lutz
Heather Kinkead
P2860cites workSafety, activity, and immune correlates of anti-PD-1 antibody in cancerQ24633070
Characteristics of tertiary lymphoid structures in primary cancersQ27012852
Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in MelanomaQ27860650
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Cancer statistics, 2014Q27861018
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Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activationQ28141319
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapyQ29617774
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escapeQ29620881
Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulationQ33848077
Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: a pilot study of safety, feasibility, and immune activationQ33887648
Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancerQ34362516
A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A Phase II trial of safety, efficacy, and immune activationQ34904065
Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profilingQ35070183
Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinomaQ36810574
12-Chemokine gene signature identifies lymph node-like structures in melanoma: potential for patient selection for immunotherapy?Q41883987
Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials.Q42818041
Neogenesis of lymphoid structures and antibody responses occur in human melanoma metastases.Q43785551
Phase 2 Trial of Single Agent Ipilimumab (Anti-CTLA-4) for Locally Advanced or Metastatic Pancreatic AdenocarcinomaQ56899396
Long-Term Survival for Patients With Non–Small-Cell Lung Cancer With Intratumoral Lymphoid StructuresQ56965922
P433issue11
P921main subjectpancreatic cancerQ212961
immunotherapyQ1427096
P304page(s)e962401
P577publication date2014-11-01
P1433published inOncoImmunologyQ18026500
P1476titlePriming the pancreatic cancer tumor microenvironment for checkpoint-inhibitor immunotherapy
P478volume3

Reverse relations

cites work (P2860)
Q37265792Actionable Intelligence Provided by Pancreatic Cancer Genomic Landscape: Are Targets for Curative Therapy On The Map?
Q33753714Cancer-FOXP3 directly activated CCL5 to recruit FOXP3+Treg cells in pancreatic ductal adenocarcinoma
Q48290538Clinical evaluation of macrophages in cancer: role in treatment, modulation and challenges.
Q60922811Combination immunotherapy and radiation therapy strategies for pancreatic cancer-targeting multiple steps in the cancer immunity cycle
Q38787052Considerations for the combination of anticancer vaccines and immune checkpoint inhibitors.
Q26768252Dendritic cell-based vaccine for pancreatic cancer in Japan
Q26778793Fueling the engine and releasing the break: combinational therapy of cancer vaccines and immune checkpoint inhibitors
Q56890107Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options
Q61448030Pancreatic cancer microenvironment: a current dilemma
Q30250026Pancreatic cancer: yesterday, today and tomorrow.
Q90749121Pancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects
Q47701712Precision Immuno-Oncology: Prospects of Individualized Immunotherapy for Pancreatic Cancer
Q53850924Rekindling cancer vaccines.
Q88318271The Immune Revolution: A Case for Priming, Not Checkpoint
Q64113812Therapeutic challenges and current immunomodulatory strategies in targeting the immunosuppressive pancreatic tumor microenvironment
Q92173942Tumour microenvironment of pancreatic cancer: immune landscape is dictated by molecular and histopathological features

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