gamma-Parvin is dispensable for hematopoiesis, leukocyte trafficking, and T-cell-dependent antibody response

scientific article published on March 2006

gamma-Parvin is dispensable for hematopoiesis, leukocyte trafficking, and T-cell-dependent antibody response is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.26.5.1817-1825.2006
P8608Fatcat IDrelease_gsizmajgtbhz7hg7u64lrom6ey
P932PMC publication ID1430247
P698PubMed publication ID16479001

P50authorReinhard FässlerQ28606518
Ari WaismanQ41560798
P2093author name stringAngelika A Noegel
Haiyan Chu
Tim Lämmermann
Michael Sixt
Attila Braun
Ingo Thievessen
P2860cites workParvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamilyQ24290812
A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreadingQ24291182
The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factorQ24314888
Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sitesQ24318346
The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cellsQ24554520
Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interactionQ24676556
The integrin-actin connection, an eternal love affairQ24676735
A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interactionQ24679147
Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesionQ24685749
Integrins: bidirectional, allosteric signaling machinesQ27860700
Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalkQ28206345
PINCH-1 Is an Obligate Partner of Integrin-linked Kinase (ILK) Functioning in Cell Shape Modulation, Motility, and SurvivalQ28208706
Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migrationQ28217164
Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signalingQ28218983
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulationQ28585627
PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stageQ28586746
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathwaysQ28645754
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrowQ29615498
Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.Q33835366
Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humansQ34103242
Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survivalQ34337340
The PINCH-ILK-parvin complexes: assembly, functions and regulation.Q35832718
Integrin-linked kinase: integrin's mysterious partnerQ35885660
Integrin signalling during tumour progressionQ35906078
Recognition of the laminin E8 cell-binding site by an integrin possessing the alpha 6 subunit is essential for epithelial polarization in developing kidney tubulesQ36223725
A role for the alphavbeta3 integrin in the transmigration of monocytesQ36256245
CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/AktQ36323145
Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interactionQ36363287
Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activationQ40657196
Role of integrin-linked kinase in leukocyte recruitment.Q40749395
C. elegans PAT-6/actopaxin plays a critical role in the assembly of integrin adhesion complexes in vivoQ42442207
Lack of beta 1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocystsQ42771254
Differential immunocompetence of macrophages derived using macrophage or granulocyte-macrophage colony-stimulating factorQ43559633
Formation and phosphorylation of the PINCH-1-integrin linked kinase-alpha-parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture, and survival.Q52564100
Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrinsQ57006559
Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody responseQ57510587
Fetal and adult hematopoietic stem cells require beta1 integrin function for colonizing fetal liver, spleen, and bone marrowQ57510593
Regulation of fibronectin matrix deposition and cell proliferation by the PINCH-ILK-CH-ILKBP complexQ64378764
A critical role of the PINCH-integrin-linked kinase interaction in the regulation of cell shape change and migrationQ77123038
CD4+CD3- cells induce Peyer's patch development: role of alpha4beta1 integrin activation by CXCR5Q78298267
P433issue5
P407language of work or nameEnglishQ1860
P921main subjecthemopoiesisQ919283
antibodyQ79460
P304page(s)1817-1825
P577publication date2006-03-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titlegamma-Parvin is dispensable for hematopoiesis, leukocyte trafficking, and T-cell-dependent antibody response
P478volume26

Reverse relations

cites work (P2860)
Q33323130A small molecule inhibitor of alpha4 integrin-dependent cell migration
Q28588987Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling
Q45986472Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.
Q36464719Focal adhesions: what's new inside
Q33761772Functional annotation of proteome encoded by human chromosome 22.
Q37855339Genetic analyses of integrin signaling
Q36735258Integrin-Linked Kinase: It's Role in the Vascular System
Q28261429Integrin-linked kinase is an adaptor with essential functions during mouse development
Q36491774Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage
Q42021259Parvin-ILK: An intimate relationship
Q33668166The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!
Q35078592The integrin-linked kinase-PINCH-parvin complex supports integrin αIIbβ3 activation
Q90263534α-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity

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