Reinhard Fässler

researcher

Reinhard Fässler is …
instance of (P31):
humanQ5

External links are
P8168FactGrid item IDQ885240
P10299Leopoldina member ID (new)reinhard-faessler
P3413Leopoldina member ID (superseded)7527
P496ORCID iD0000-0002-0145-6937

P108employerMax Planck SocietyQ158085
P734family nameFässlerQ66737788
FässlerQ66737788
FässlerQ66737788
P735given nameReinhardQ18177338
ReinhardQ18177338
P463member ofGerman Academy of Sciences LeopoldinaQ543804
P106occupationresearcherQ1650915
P21sex or gendermaleQ6581097

Reverse relations

author (P50)
Q46158180A VASP-Rac-soluble guanylyl cyclase pathway controls cGMP production in adipocytes
Q40423523A firm grip does not always pay off: a new Phact(r) 4 integrin signaling
Q48099760A forceful connection: mechanoregulation of oncogenic YAP.
Q36512219A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy
Q44965368A molecular toolkit for the functionalization of titanium-based biomaterials that selectively control integrin-mediated cell adhesion
Q30528487A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis
Q40364120ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins
Q28511542All four members of the Ten-m/Odz family of transmembrane proteins form dimers
Q36661709An essential requirement for β1 integrin in the assembly of extracellular matrix proteins within the vascular wall
Q36909825Analysis of integrin functions in peri-implantation embryos, hematopoietic system, and skin
Q30541878Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis
Q36161003Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activity
Q45986472Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.
Q35216941Beta1 integrin cytoplasmic tyrosines promote skin tumorigenesis independent of their phosphorylation
Q37137984Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells
Q35227393Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism
Q36676760Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity
Q33441380Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion
Q28269425Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance
Q30486061Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity
Q28508685Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis
Q36571060Beta1 integrins: zip codes and signaling relay for blood cells
Q37475103Biological role of prolyl 3-hydroxylation in type IV collagen
Q28512175Bral1: its role in diffusion barrier formation and conduction velocity in the CNS
Q28511300Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory
Q37166768CD98hc facilitates B cell proliferation and adaptive humoral immunity
Q112301144CDK1-cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry
Q24537474Cartilage oligomeric matrix protein-deficient mice have normal skeletal development
Q51442060Cell-Intrinsic Adaptation Arising from Chronic Ablation of a Key Rho GTPase Regulator.
Q40234901Chondroitin sulfate perlecan enhances collagen fibril formation. Implications for perlecan chondrodysplasias
Q39681478Chondromodulin I is dispensable during enchondral ossification and eye development
Q54483880Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type Iγ in vivo.
Q44315309Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo
Q52088676Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system.
Q31021873Consequences of loss of PINCH2 expression in mice
Q49644293Corrigendum: Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second
Q38298213Cre recombinase induces DNA damage and tetraploidy in the absence of loxP sites
Q28588278Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling
Q36324123Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain
Q42845718Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts - role of TGFβ1 levels and RhoA activity
Q28585295Differential gene expression between sensory neocortical areas: potential roles for Ten_m3 and Bcl6 in patterning visual and somatosensory pathways
Q57385104Differentiation of Embryonal Stem Cells into Keratinocytes: Comparison of Wild-Type and β1Integrin-Deficient Cells
Q24324657Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha
Q34130320Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography
Q30514206Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation
Q37061845Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma
Q40549682Dystroglycan in skin and cutaneous cells: beta-subunit is shed from the cell surface
Q36228711ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability
Q28585722Elimination of epiplakin by gene targeting results in acceleration of keratinocyte migration in mice
Q36149239Ena/VASP is required for endothelial barrier function in vivo
Q28508460Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities
Q53600682Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts.
Q44508747Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration
Q51812706Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1.
Q47370705Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second
Q46340921Formation and activation of fibroblast spheroids depend on fibronectin-integrin interaction
Q48368670Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon
Q39205680Functionalizing αvβ3- or α5β1-selective integrin antagonists for surface coating: a method to discriminate integrin subtypes in vitro
Q37855339Genetic analyses of integrin signaling
Q39741501Genetic analysis of beta1 integrin "activation motifs" in mice
Q28586728Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis
Q28512972Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes
Q47931618Guido Tarone, Ph.D. (1951-2015).
Q44010133Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin
Q37533427How ILK and kindlins cooperate to orchestrate integrin signaling
Q36403372ILK, PINCH and parvin: the tIPP of integrin signalling
Q40014118Improvement of reporter activity by IRES-mediated polycistronic reporter system
Q43565259In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis
Q35846812Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function
Q54527822Induction of membrane circular dorsal ruffles requires co-signalling of integrin-ILK-complex and EGF receptor.
Q42153207Insulin resistance in striated muscle-specific integrin receptor beta1-deficient mice
Q90854393Integrin activation by talin, kindlin and mechanical forces
Q39938242Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis
Q46803220Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability
Q39937866Integrin trafficking regulated by Rab21 is necessary for cytokinesis
Q55056187Integrin-linked kinase at a glance.
Q42066604Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae
Q42579182Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction
Q28261429Integrin-linked kinase is an adaptor with essential functions during mouse development
Q30480583Integrin-linked kinase is required for epidermal and hair follicle morphogenesis
Q28587844Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system
Q40771629Integrin-linked kinase regulates chondrocyte shape and proliferation
Q42077991Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development
Q36491774Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage
Q35885660Integrin-linked kinase: integrin's mysterious partner
Q39016068Integrin-mediated mechanotransduction
Q33944185Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling
Q51928095Integrins anchor the invasive machinery.
Q37271595Integrins are required for the differentiation of visceral endoderm
Q34603045Integrins in invasive growth
Q38794531Integrins synergise to induce expression of the MRTF-A-SRF target gene ISG15 for promoting cancer cell invasion
Q30830770Interactions with fibronectin attenuate the virulence of Streptococcus pyogenes
Q38716553Introduction to the ECR special issue, "Mechanosensing via Cell-Matrix Adhesions".
Q39466114Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation
Q28507652Kindlin-2 controls bidirectional signaling of integrins
Q38358692Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin
Q40045183Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading.
Q28595084Kindlin-3 is essential for integrin activation and platelet aggregation
Q28507135Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells
Q30552379Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells
Q27308783Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells
Q42197118Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption
Q51733905Knockdown and knockout of β1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling.
Q40512860Laminin isoforms differentially regulate adhesion, spreading, proliferation, and ERK activation of beta1 integrin-null cells
Q35705635Laminin: the crux of basement membrane assembly
Q35622419Lentiviral transgene vectors
Q33389852Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction
Q34394834Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes
Q51891549Loss of migfilin expression has no overt consequences on murine development and homeostasis.
Q34726698Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo
Q36382181Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice
Q55171163Lucky kindlin: A cloverleaf at the integrin tail.
Q36324592Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation
Q37360853Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails
Q30505376Mechanoinduction of lymph vessel expansion
Q26849684Mechanosensitivity and compositional dynamics of cell-matrix adhesions
Q41965697Membrane tension drives ligand-independent integrin signaling
Q60955777Microenvironment-derived ADAM28 prevents cancer dissemination
Q28590384Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation
Q40965315Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice
Q44650514Modulation of Ca2+ sensitivity by cyclic nucleotides in smooth muscle from protein kinase G-deficient mice
Q34269023Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets☆
Q42164315Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation
Q28508913Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice
Q112645503Neutrophils direct preexisting matrix to initiate repair in damaged tissues
Q28510333None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion
Q33502785Nonviral in situ green fluorescent protein labeling and culture of primary, adult human hair follicle epithelial progenitor cells
Q54486346PINCH-1 promotes Bcl-2-dependent survival signalling and inhibits JNK-mediated apoptosis in the primitive endoderm.
Q33968025PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha
Q28586746PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage
Q28589673PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions
Q30497801PIPKIγ90 Negatively Regulates LFA-1–Mediated Adhesion and Activation in Antigen-Induced CD4+ T Cells
Q42254716Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation
Q30477630Plasma fibronectin promotes thrombus growth and stability in injured arterioles
Q30487678Profilin 1 is required for abscission during late cytokinesis of chondrocytes
Q39589743Profilin1 regulates sternum development and endochondral bone formation
Q43232698Protein kinase G controls brown fat cell differentiation and mitochondrial biogenesis
Q30482362Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin
Q30498837Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins
Q41782395Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD
Q46975937Regulation of integrin activity by MIA.
Q37858134Regulation of membrane traffic by integrin signaling
Q28253861Regulation of neural progenitor proliferation and survival by beta1 integrins
Q53906565Role of collagen type II and perlecan in skeletal development.
Q46458771SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function
Q39227376Sensing the mechano-chemical properties of the extracellular matrix
Q39860911Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry
Q38975551Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability
Q30445390Staphylococcus aureus fibronectin binding protein-A induces motile attachment sites and complex actin remodeling in living endothelial cells
Q47674930Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development
Q34462862Targeted disruption of the murine zyxin gene
Q27334204Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision
Q30979772Tenomodulin is necessary for tenocyte proliferation and tendon maturation
Q57713422The Kank family proteins in adhesion dynamics
Q37600289The Kindlin protein family: new members to the club of focal adhesion proteins
Q28513797The Kindlins: subcellular localization and expression during murine development
Q39743726The RGD motif in fibronectin is essential for development but dispensable for fibril assembly
Q40344279The contribution of beta1 integrins to neuronal migration and differentiation depends on extracellular matrix molecules
Q30441899The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis
Q35126974The focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites
Q38197886The integrin adhesome: from genes and proteins to human disease
Q47692376The integrin coactivator Kindlin-3 is not required for lymphocyte diapedesis
Q24676735The integrin-actin connection, an eternal love affair
Q28077899The kindlin family: functions, signaling properties and implications for human disease
Q37769018The kindlins at a glance
Q37552184The mechanism of kindlin-mediated activation of integrin αIIbβ3.
Q30818120The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain
Q37202232The role of integrin binding sites in fibronectin matrix assembly in vivo
Q41610666The role of integrin-linked kinase in the molecular architecture of focal adhesions
Q35123983The role of laminin in embryonic cell polarization and tissue organization
Q46005089The stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase.
Q37483142The tail of integrins, talin, and kindlins
Q40308782The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation
Q40331797Threonine 788 in integrin subunit beta1 regulates integrin activation
Q52583362Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling.
Q28511662Type IX collagen knock-out mouse shows progressive hearing loss
Q28591920Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice
Q45964944Versican V2 assembles the extracellular matrix surrounding the nodes of ranvier in the CNS.
Q39807801beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity
Q46482139beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia
Q42124473gamma-Parvin is dispensable for hematopoiesis, leukocyte trafficking, and T-cell-dependent antibody response
Q33809470β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain
Q42519298β1 integrins with individually disrupted cytoplasmic NPxY motifs are embryonic lethal but partially active in the epidermis
Q39147447β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

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