review article | Q7318358 |
scholarly article | Q13442814 |
P6179 | Dimensions Publication ID | 1021616527 |
P356 | DOI | 10.1038/NRM3769 |
P698 | PubMed publication ID | 24651544 |
P50 | author | Reinhard Fässler | Q28606518 |
P2093 | author name string | Benjamin Geiger | |
Kyle R Legate | |||
Sabina E Winograd-Katz | |||
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Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome | Q24532354 | ||
The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell | Q24598442 | ||
Gain of glycosylation in integrin α3 causes lung disease and nephrotic syndrome | Q36498046 | ||
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Efalizumab: a review of its use in the management of chronic moderate-to-severe plaque psoriasis | Q37377900 | ||
VP7 mediates the interaction of rotaviruses with integrin alphavbeta3 through a novel integrin-binding site | Q37567855 | ||
The role of focal adhesion kinase in tumor initiation and progression. | Q37582150 | ||
Oncogenic ILK, tumor suppression and all that JNK. | Q37634884 | ||
Kindler syndrome pathogenesis and fermitin family homologue 1 (kindlin-1) function. | Q37640777 | ||
Alopecia in epidermolysis bullosa | Q37640793 | ||
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Decoding signalling networks by mass spectrometry-based proteomics | Q37749492 | ||
Overview of epidermolysis bullosa | Q37761191 | ||
Frontiers of microscopy-based research into cell–matrix adhesions | Q37786076 | ||
Integrin-mediated uptake of fibronectin-binding bacteria | Q37874353 | ||
The role of β3-integrins in tumor angiogenesis: context is everything | Q37874786 | ||
Structural basis for activation and inhibition of class I phosphoinositide 3-kinases | Q37947094 | ||
Vedolizumab for the treatment of ulcerative colitis and Crohn's disease | Q24630083 | ||
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Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction | Q28190028 | ||
Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk | Q28206345 | ||
Congenital poikiloderma with traumatic bulla formation and progressive cutaneous atrophy | Q28210027 | ||
Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy | Q28244992 | ||
Integrin signalling adaptors: not only figurants in the cancer story | Q28299126 | ||
Nanoscale architecture of integrin-based cell adhesions | Q28299215 | ||
Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency | Q28301257 | ||
Mutations in ZASP define a novel form of muscular dystrophy in humans | Q28304080 | ||
A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast function | Q28364534 | ||
Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile | Q28390408 | ||
Role for the alpha7beta1 integrin in vascular development and integrity | Q28504523 | ||
Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis | Q28504659 | ||
Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells | Q28507135 | ||
The Kindlins: subcellular localization and expression during murine development | Q28513797 | ||
Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathy | Q28587879 | ||
The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration | Q28591521 | ||
Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice | Q28591790 | ||
Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival | Q28592841 | ||
Kindlin-3 is essential for integrin activation and platelet aggregation | Q28595084 | ||
Integrins in cancer: biological implications and therapeutic opportunities | Q29614536 | ||
Genetic mapping in human disease | Q29614943 | ||
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen | Q29615061 | ||
Environmental sensing through focal adhesions | Q29615211 | ||
Regulation of wound healing by growth factors and cytokines | Q29615242 | ||
Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment | Q29615852 | ||
Functional atlas of the integrin adhesome | Q29617077 | ||
The genetic association database | Q29617244 | ||
Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease | Q29619085 | ||
RNA sequencing: advances, challenges and opportunities | Q29619605 | ||
Requirement of vascular integrin alpha v beta 3 for angiogenesis | Q29619681 | ||
Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown | Q30437106 | ||
Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathy | Q35103087 | ||
Beta3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice | Q35144122 | ||
Activation of RhoA in podocytes induces focal segmental glomerulosclerosis | Q35210190 | ||
Focal adhesion kinase regulation of neovascularization | Q35269444 | ||
miR-31 is a broad regulator of β1-integrin expression and function in cancer cells | Q35560738 | ||
Cooperation between VEGF and beta3 integrin during cardiac vascular development | Q35642757 | ||
Integrin alphavbeta3 is a coreceptor for human cytomegalovirus | Q35865693 | ||
Integrin α3 mutations with kidney, lung, and skin disease | Q35925648 | ||
MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits | Q36004007 | ||
Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling | Q36117214 | ||
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts | Q36232642 | ||
Complementary distributions of vinculin and dystrophin define two distinct sarcolemma domains in smooth muscle | Q36233031 | ||
α3β1 Integrin Is Required for Normal Development of the Epidermal Basement Membrane | Q36274145 | ||
CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria-induced detachment of epithelial cells | Q36320615 | ||
ILK, PINCH and parvin: the tIPP of integrin signalling | Q36403372 | ||
Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice. | Q36416832 | ||
Cellular adhesion molecules as targets for bacterial infection | Q36425003 | ||
Leukocyte adhesion deficiency-III in an African-American patient | Q46512487 | ||
Identification of a metavinculin missense mutation, R975W, associated with both hypertrophic and dilated cardiomyopathy | Q46763552 | ||
ZASPopathy with childhood-onset distal myopathy | Q47726322 | ||
Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. | Q52200996 | ||
Metavinculin mutations alter actin interaction in dilated cardiomyopathy. | Q52545136 | ||
Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis. | Q53627788 | ||
Podocyte Wnt/ß-catenin pathway is activated by integrin-linked kinase in clinical and experimental focal segmental glomerulosclerosis. | Q54559229 | ||
A ZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathy | Q57185441 | ||
Terminal B cell differentiation is skewed by deregulated interleukin-6 secretion in 2 integrin-deficient mice | Q57339920 | ||
Tailoring of Integrin Ligands: Probing the Charge Capability of the Metal Ion-Dependent Adhesion Site | Q58855708 | ||
Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins | Q61631829 | ||
Targeting Focal Adhesion Kinase With Small Interfering RNA Prevents and Reverses Load-Induced Cardiac Hypertrophy in Mice | Q61737469 | ||
Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis | Q71849956 | ||
A role for apoptosis in the control of neutrophil homeostasis in the circulation: insights from CD18-deficient mice | Q78410382 | ||
The role of alpha3beta1 integrin in determining the supramolecular organization of laminin-5 in the extracellular matrix of keratinocytes | Q78880917 | ||
Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice | Q79334337 | ||
Obstructive hypertrophic cardiomyopathy is associated with reduced expression of vinculin in the intercalated disc | Q80204091 | ||
Increased expression and phosphorylation of focal adhesion kinase correlates with dysfunction in the volume-overloaded human heart | Q80322424 | ||
Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in beta3-integrin-deficient mice | Q81085089 | ||
Contemporary use of glycoprotein IIb/IIIa inhibitors | Q83205856 | ||
A missense mutation in a ubiquitously expressed protein, vinculin, confers susceptibility to hypertrophic cardiomyopathy | Q83377734 | ||
Natalizumab for moderate to severe Crohn's disease in clinical practice: the Mayo Clinic Rochester experience | Q83656106 | ||
Recurrence of focal segmental glomerular sclerosis (FSGS) after renal transplantation | Q84816545 | ||
Conditional ablation of integrin alpha-6 in mouse epidermis leads to skin fragility and inflammation | Q85237428 | ||
Myocyte-restricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophy | Q30439445 | ||
Spontaneous skin ulceration and defective T cell function in CD18 null mice | Q30441234 | ||
Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells | Q30443448 | ||
Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction | Q30490566 | ||
Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins | Q30498837 | ||
Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization. | Q30506115 | ||
LAD-III, a novel group of leukocyte integrin activation deficiencies. | Q30882084 | ||
Cell invasion by Neisseria meningitidis requires a functional interplay between the focal adhesion kinase, Src and cortactin | Q31071346 | ||
Quantitative multicolor compositional imaging resolves molecular domains in cell-matrix adhesions | Q33326632 | ||
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction | Q33389852 | ||
Molecular mechanism of alpha2beta1 integrin interaction with human echovirus 1. | Q33598453 | ||
Pathogenic hantaviruses bind plexin-semaphorin-integrin domains present at the apex of inactive, bent alphavbeta3 integrin conformers | Q33762496 | ||
Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. | Q33835366 | ||
Quantitative, high-resolution proteomics for data-driven systems biology | Q33891413 | ||
Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts | Q33939357 | ||
Reconstructing adhesion structures in tissues by cryo-electron tomography of vitrified frozen sections | Q34074961 | ||
Analysis of the mammalian talin2 gene TLN2. | Q34088569 | ||
The switchable integrin adhesome. | Q34111432 | ||
Wound-healing defect of CD18(-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiation | Q34116215 | ||
Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography | Q34130320 | ||
Increased expression of integrin-linked kinase improves cardiac function and decreases mortality in dilated cardiomyopathy model of rats | Q34163462 | ||
Proteomic analysis of integrin adhesion complexes | Q34176055 | ||
Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models | Q34216342 | ||
ILK induces cardiomyogenesis in the human heart | Q34292636 | ||
Recurrent mutations in kindlin-1, a novel keratinocyte focal contact protein, in the autosomal recessive skin fragility and photosensitivity disorder, Kindler syndrome. | Q34298513 | ||
Identification of nephropathy candidate genes by comparing sclerosis-prone and sclerosis-resistant mouse strain kidney transcriptomes | Q34343895 | ||
Vinculin knockout results in heart and brain defects during embryonic development. | Q34458643 | ||
Integrins in invasive growth | Q34603045 | ||
Absence of preference for social novelty and increased grooming in integrin β3 knockout mice: initial studies and future directions | Q34777773 | ||
Cortactin: a multifunctional regulator of cellular invasiveness | Q34891306 | ||
microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C. | Q34993968 | ||
Molecular architecture and function of matrix adhesions | Q35006506 | ||
Three novel beta-propeller mutations causing Glanzmann thrombasthenia result in production of normally stable pro-alphaIIb, but variably impaired progression of pro-alphaIIbbeta3 from endoplasmic reticulum to Golgi | Q35039053 | ||
Monoclonal antibodies and recombinant immunoglobulins for the treatment of multiple sclerosis. | Q37968620 | ||
Integrins as therapeutic targets. | Q38013361 | ||
Opening the floodgates: proteomics and the integrin adhesome | Q38021231 | ||
The ever-expanding spectrum of congenital muscular dystrophies | Q38029277 | ||
Cilengitide: a prototypic integrin inhibitor for the treatment of glioblastoma and other malignancies | Q38032282 | ||
A single amino acid substitution flanking the fourth calcium binding domain of alpha IIb prevents maturation of the alpha IIb beta 3 integrin complex | Q38311244 | ||
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments | Q39147447 | ||
Enhanced radiosensitivity of head and neck squamous cell carcinoma cells by β1 integrin inhibition | Q39322499 | ||
ZEB2 upregulates integrin α5 expression through cooperation with Sp1 to induce invasion during epithelial-mesenchymal transition of human cancer cells | Q39415949 | ||
IL-8 increases integrin expression and cell motility in human chondrosarcoma cells | Q39540610 | ||
Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase | Q39577792 | ||
Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by Rho family GTPases. | Q39581979 | ||
IGF-I enhances α5β1 integrin expression and cell motility in human chondrosarcoma cells | Q39587526 | ||
miR-124a is frequently down-regulated in glioblastoma and is involved in migration and invasion. | Q39613292 | ||
Major host factors involved in epithelial cell invasion of Campylobacter jejuni: role of fibronectin, integrin beta1, FAK, Tiam-1, and DOCK180 in activating Rho GTPase Rac1. | Q39614214 | ||
TNF-α increases αvβ3 integrin expression and migration in human chondrosarcoma cells | Q39653288 | ||
Beta2 integrins are required for skin homing of primed T cells but not for priming naive T cells | Q39737395 | ||
Identification of genes that regulate epithelial cell migration using an siRNA screening approach | Q39892281 | ||
Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma. | Q39954054 | ||
Increase of integrin-linked kinase activity in cultured podocytes upon stimulation with plasma from patients with recurrent FSGS. | Q39971911 | ||
Integrin-linked kinase is an essential link between integrins and uptake of bacterial pathogens by epithelial cells. | Q40324201 | ||
Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice. | Q40454581 | ||
High affinity interactions of Coxsackievirus A9 with integrin alphavbeta3 (CD51/61) require the CYDMKTTC sequence of beta3, but do not require the RGD sequence of the CAV-9 VP1 protein. | Q40885324 | ||
Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus | Q41869916 | ||
Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption | Q42197118 | ||
Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration | Q42480617 | ||
Partial loss of epithelial phenotype in kindlin-1-deficient keratinocytes | Q42501974 | ||
Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice | Q42519143 | ||
Human-Restricted Bacterial Pathogens Block Shedding of Epithelial Cells by Stimulating Integrin Activation | Q42919010 | ||
Genetic background strongly influences the severity of glomerulosclerosis in mice | Q43059362 | ||
Focal adhesion kinase is critical for entry of Kaposi's sarcoma-associated herpesvirus into target cells | Q43181946 | ||
FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complex | Q43206192 | ||
Beta(2) integrin deficiency yields unconventional double-negative T cells distinct from mature classical natural killer T cells in mice | Q43279065 | ||
Gene targeting yields a CD18-mutant mouse for study of inflammation. | Q44297775 | ||
Defective integrin switch and matrix composition at alpha 7-deficient myotendinous junctions precede the onset of muscular dystrophy in mice. | Q44316959 | ||
A novel genetic leukocyte adhesion deficiency in subsecond triggering of integrin avidity by endothelial chemokines results in impaired leukocyte arrest on vascular endothelium under shear flow. | Q44321392 | ||
Beta3 integrin deficiency promotes cardiac hypertrophy and inflammation | Q44356848 | ||
A novel homozygous splice junction mutation in GPIIb associated with alternative splicing, nonsense-mediated decay of GPIIb-mRNA, and type II Glanzmann's thrombasthenia. | Q44518825 | ||
Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins | Q44956435 | ||
Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling. | Q45227038 | ||
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment. | Q45986472 | ||
LAD-1/variant syndrome is caused by mutations in FERMT3. | Q46209404 | ||
Cellular invasion by Staphylococcus aureus reveals a functional link between focal adhesion kinase and cortactin in integrin-mediated internalisation | Q46458595 | ||
SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function | Q46458771 | ||
P433 | issue | 4 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 273-288 | |
P577 | publication date | 2014-04-01 | |
P1433 | published in | Nature Reviews Molecular Cell Biology | Q1573120 |
P1476 | title | The integrin adhesome: from genes and proteins to human disease | |
P478 | volume | 15 |
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Q38851702 | Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix |
Q92643473 | Integrins as biomechanical sensors of the microenvironment |
Q49989826 | Integrins promote axonal regeneration after injury of the nervous system. |
Q38496617 | Intracellular signalling during neutrophil recruitment |
Q39776870 | Isolation of integrin-based adhesion complexes |
Q90484439 | KANK2 Links αVβ5 Focal Adhesions to Microtubules and Regulates Sensitivity to Microtubule Poisons and Cell Migration |
Q38358692 | Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin |
Q51153513 | Laminins in Epithelial Cell Polarization: Old Questions in Search of New Answers. |
Q55446080 | Live cell imaging reveals focal adhesions mechanoresponses in mammary epithelial cells under sustained equibiaxial stress. |
Q59800401 | Long non-coding RNA PICSAR decreases adhesion and promotes migration of squamous carcinoma cells by downregulating α2β1 and α5β1 integrin expression |
Q46840753 | Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy. |
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