The integrin adhesome: from genes and proteins to human disease

scientific article published on April 2014

The integrin adhesome: from genes and proteins to human disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1021616527
P356DOI10.1038/NRM3769
P698PubMed publication ID24651544

P50authorReinhard FässlerQ28606518
P2093author name stringBenjamin Geiger
Kyle R Legate
Sabina E Winograd-Katz
P2860cites workZASP: a new Z-band alternatively spliced PDZ-motif proteinQ22010444
Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic informationQ24288912
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturationQ24297812
Kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation, and motility of epidermal keratinocytesQ24305400
A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humansQ24313548
Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activationQ24313629
Mutations in the integrin alpha7 gene cause congenital myopathyQ24317420
Absence of integrin alpha 7 causes a novel form of muscular dystrophyQ24323372
Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndromeQ24532354
The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cellQ24598442
Gain of glycosylation in integrin α3 causes lung disease and nephrotic syndromeQ36498046
Current insights into the formation and breakdown of hemidesmosomes.Q36498608
Subversion of CtBP1-controlled macropinocytosis by human adenovirus serotype 3.Q36570681
Precision proteomics: the case for high resolution and high mass accuracyQ36985018
Integrins in angiogenesis and lymphangiogenesisQ37170752
Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death.Q37292925
Leukocyte adhesion deficiency type 1 (LAD-1)/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrinsQ37372862
Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complexQ37374506
Efalizumab: a review of its use in the management of chronic moderate-to-severe plaque psoriasisQ37377900
VP7 mediates the interaction of rotaviruses with integrin alphavbeta3 through a novel integrin-binding siteQ37567855
The role of focal adhesion kinase in tumor initiation and progression.Q37582150
Oncogenic ILK, tumor suppression and all that JNK.Q37634884
Kindler syndrome pathogenesis and fermitin family homologue 1 (kindlin-1) function.Q37640777
Alopecia in epidermolysis bullosaQ37640793
A polygenic mouse model of psoriasiform skin disease in CD18-deficient miceQ37710538
Decoding signalling networks by mass spectrometry-based proteomicsQ37749492
Overview of epidermolysis bullosaQ37761191
Frontiers of microscopy-based research into cell–matrix adhesionsQ37786076
Integrin-mediated uptake of fibronectin-binding bacteriaQ37874353
The role of β3-integrins in tumor angiogenesis: context is everythingQ37874786
Structural basis for activation and inhibition of class I phosphoinositide 3-kinasesQ37947094
Vedolizumab for the treatment of ulcerative colitis and Crohn's diseaseQ24630083
Deleted in liver cancer-1 (DLC-1): a tumor suppressor not just for liverQ24645379
Immunolocalization of meta-vinculin in human smooth and cardiac musclesQ24679776
Integrins: versatility, modulation, and signaling in cell adhesionQ27860844
Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombastheniaQ28118972
Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compactionQ28190028
Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalkQ28206345
Congenital poikiloderma with traumatic bulla formation and progressive cutaneous atrophyQ28210027
Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathyQ28244992
Integrin signalling adaptors: not only figurants in the cancer storyQ28299126
Nanoscale architecture of integrin-based cell adhesionsQ28299215
Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiencyQ28301257
Mutations in ZASP define a novel form of muscular dystrophy in humansQ28304080
A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast functionQ28364534
Mice carrying a complete deletion of the talin2 coding sequence are viable and fertileQ28390408
Role for the alpha7beta1 integrin in vascular development and integrityQ28504523
Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosisQ28504659
Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cellsQ28507135
The Kindlins: subcellular localization and expression during murine developmentQ28513797
Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathyQ28587879
The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migrationQ28591521
Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in miceQ28591790
Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survivalQ28592841
Kindlin-3 is essential for integrin activation and platelet aggregationQ28595084
Integrins in cancer: biological implications and therapeutic opportunitiesQ29614536
Genetic mapping in human diseaseQ29614943
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screenQ29615061
Environmental sensing through focal adhesionsQ29615211
Regulation of wound healing by growth factors and cytokinesQ29615242
Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachmentQ29615852
Functional atlas of the integrin adhesomeQ29617077
The genetic association databaseQ29617244
Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex diseaseQ29619085
RNA sequencing: advances, challenges and opportunitiesQ29619605
Requirement of vascular integrin alpha v beta 3 for angiogenesisQ29619681
Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdownQ30437106
Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathyQ35103087
Beta3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic miceQ35144122
Activation of RhoA in podocytes induces focal segmental glomerulosclerosisQ35210190
Focal adhesion kinase regulation of neovascularizationQ35269444
miR-31 is a broad regulator of β1-integrin expression and function in cancer cellsQ35560738
Cooperation between VEGF and beta3 integrin during cardiac vascular developmentQ35642757
Integrin alphavbeta3 is a coreceptor for human cytomegalovirusQ35865693
Integrin α3 mutations with kidney, lung, and skin diseaseQ35925648
MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunitsQ36004007
Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodelingQ36117214
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblastsQ36232642
Complementary distributions of vinculin and dystrophin define two distinct sarcolemma domains in smooth muscleQ36233031
α3β1 Integrin Is Required for Normal Development of the Epidermal Basement MembraneQ36274145
CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria-induced detachment of epithelial cellsQ36320615
ILK, PINCH and parvin: the tIPP of integrin signallingQ36403372
Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice.Q36416832
Cellular adhesion molecules as targets for bacterial infectionQ36425003
Leukocyte adhesion deficiency-III in an African-American patientQ46512487
Identification of a metavinculin missense mutation, R975W, associated with both hypertrophic and dilated cardiomyopathyQ46763552
ZASPopathy with childhood-onset distal myopathyQ47726322
Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice.Q52200996
Metavinculin mutations alter actin interaction in dilated cardiomyopathy.Q52545136
Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis.Q53627788
Podocyte Wnt/ß-catenin pathway is activated by integrin-linked kinase in clinical and experimental focal segmental glomerulosclerosis.Q54559229
A ZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathyQ57185441
Terminal B cell differentiation is skewed by deregulated interleukin-6 secretion in 2 integrin-deficient miceQ57339920
Tailoring of Integrin Ligands: Probing the Charge Capability of the Metal Ion-Dependent Adhesion SiteQ58855708
Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrinsQ61631829
Targeting Focal Adhesion Kinase With Small Interfering RNA Prevents and Reverses Load-Induced Cardiac Hypertrophy in MiceQ61737469
Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesisQ71849956
A role for apoptosis in the control of neutrophil homeostasis in the circulation: insights from CD18-deficient miceQ78410382
The role of alpha3beta1 integrin in determining the supramolecular organization of laminin-5 in the extracellular matrix of keratinocytesQ78880917
Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic miceQ79334337
Obstructive hypertrophic cardiomyopathy is associated with reduced expression of vinculin in the intercalated discQ80204091
Increased expression and phosphorylation of focal adhesion kinase correlates with dysfunction in the volume-overloaded human heartQ80322424
Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in beta3-integrin-deficient miceQ81085089
Contemporary use of glycoprotein IIb/IIIa inhibitorsQ83205856
A missense mutation in a ubiquitously expressed protein, vinculin, confers susceptibility to hypertrophic cardiomyopathyQ83377734
Natalizumab for moderate to severe Crohn's disease in clinical practice: the Mayo Clinic Rochester experienceQ83656106
Recurrence of focal segmental glomerular sclerosis (FSGS) after renal transplantationQ84816545
Conditional ablation of integrin alpha-6 in mouse epidermis leads to skin fragility and inflammationQ85237428
Myocyte-restricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophyQ30439445
Spontaneous skin ulceration and defective T cell function in CD18 null miceQ30441234
Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cellsQ30443448
Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransductionQ30490566
Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteinsQ30498837
Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization.Q30506115
LAD-III, a novel group of leukocyte integrin activation deficiencies.Q30882084
Cell invasion by Neisseria meningitidis requires a functional interplay between the focal adhesion kinase, Src and cortactinQ31071346
Quantitative multicolor compositional imaging resolves molecular domains in cell-matrix adhesionsQ33326632
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunctionQ33389852
Molecular mechanism of alpha2beta1 integrin interaction with human echovirus 1.Q33598453
Pathogenic hantaviruses bind plexin-semaphorin-integrin domains present at the apex of inactive, bent alphavbeta3 integrin conformersQ33762496
Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.Q33835366
Quantitative, high-resolution proteomics for data-driven systems biologyQ33891413
Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclastsQ33939357
Reconstructing adhesion structures in tissues by cryo-electron tomography of vitrified frozen sectionsQ34074961
Analysis of the mammalian talin2 gene TLN2.Q34088569
The switchable integrin adhesome.Q34111432
Wound-healing defect of CD18(-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiationQ34116215
Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomographyQ34130320
Increased expression of integrin-linked kinase improves cardiac function and decreases mortality in dilated cardiomyopathy model of ratsQ34163462
Proteomic analysis of integrin adhesion complexesQ34176055
Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse modelsQ34216342
ILK induces cardiomyogenesis in the human heartQ34292636
Recurrent mutations in kindlin-1, a novel keratinocyte focal contact protein, in the autosomal recessive skin fragility and photosensitivity disorder, Kindler syndrome.Q34298513
Identification of nephropathy candidate genes by comparing sclerosis-prone and sclerosis-resistant mouse strain kidney transcriptomesQ34343895
Vinculin knockout results in heart and brain defects during embryonic development.Q34458643
Integrins in invasive growthQ34603045
Absence of preference for social novelty and increased grooming in integrin β3 knockout mice: initial studies and future directionsQ34777773
Cortactin: a multifunctional regulator of cellular invasivenessQ34891306
microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C.Q34993968
Molecular architecture and function of matrix adhesionsQ35006506
Three novel beta-propeller mutations causing Glanzmann thrombasthenia result in production of normally stable pro-alphaIIb, but variably impaired progression of pro-alphaIIbbeta3 from endoplasmic reticulum to GolgiQ35039053
Monoclonal antibodies and recombinant immunoglobulins for the treatment of multiple sclerosis.Q37968620
Integrins as therapeutic targets.Q38013361
Opening the floodgates: proteomics and the integrin adhesomeQ38021231
The ever-expanding spectrum of congenital muscular dystrophiesQ38029277
Cilengitide: a prototypic integrin inhibitor for the treatment of glioblastoma and other malignanciesQ38032282
A single amino acid substitution flanking the fourth calcium binding domain of alpha IIb prevents maturation of the alpha IIb beta 3 integrin complexQ38311244
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironmentsQ39147447
Enhanced radiosensitivity of head and neck squamous cell carcinoma cells by β1 integrin inhibitionQ39322499
ZEB2 upregulates integrin α5 expression through cooperation with Sp1 to induce invasion during epithelial-mesenchymal transition of human cancer cellsQ39415949
IL-8 increases integrin expression and cell motility in human chondrosarcoma cellsQ39540610
Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinaseQ39577792
Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by Rho family GTPases.Q39581979
IGF-I enhances α5β1 integrin expression and cell motility in human chondrosarcoma cellsQ39587526
miR-124a is frequently down-regulated in glioblastoma and is involved in migration and invasion.Q39613292
Major host factors involved in epithelial cell invasion of Campylobacter jejuni: role of fibronectin, integrin beta1, FAK, Tiam-1, and DOCK180 in activating Rho GTPase Rac1.Q39614214
TNF-α increases αvβ3 integrin expression and migration in human chondrosarcoma cellsQ39653288
Beta2 integrins are required for skin homing of primed T cells but not for priming naive T cellsQ39737395
Identification of genes that regulate epithelial cell migration using an siRNA screening approachQ39892281
Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma.Q39954054
Increase of integrin-linked kinase activity in cultured podocytes upon stimulation with plasma from patients with recurrent FSGS.Q39971911
Integrin-linked kinase is an essential link between integrins and uptake of bacterial pathogens by epithelial cells.Q40324201
Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice.Q40454581
High affinity interactions of Coxsackievirus A9 with integrin alphavbeta3 (CD51/61) require the CYDMKTTC sequence of beta3, but do not require the RGD sequence of the CAV-9 VP1 protein.Q40885324
Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulusQ41869916
Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorptionQ42197118
Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migrationQ42480617
Partial loss of epithelial phenotype in kindlin-1-deficient keratinocytesQ42501974
Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null miceQ42519143
Human-Restricted Bacterial Pathogens Block Shedding of Epithelial Cells by Stimulating Integrin ActivationQ42919010
Genetic background strongly influences the severity of glomerulosclerosis in miceQ43059362
Focal adhesion kinase is critical for entry of Kaposi's sarcoma-associated herpesvirus into target cellsQ43181946
FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complexQ43206192
Beta(2) integrin deficiency yields unconventional double-negative T cells distinct from mature classical natural killer T cells in miceQ43279065
Gene targeting yields a CD18-mutant mouse for study of inflammation.Q44297775
Defective integrin switch and matrix composition at alpha 7-deficient myotendinous junctions precede the onset of muscular dystrophy in mice.Q44316959
A novel genetic leukocyte adhesion deficiency in subsecond triggering of integrin avidity by endothelial chemokines results in impaired leukocyte arrest on vascular endothelium under shear flow.Q44321392
Beta3 integrin deficiency promotes cardiac hypertrophy and inflammationQ44356848
A novel homozygous splice junction mutation in GPIIb associated with alternative splicing, nonsense-mediated decay of GPIIb-mRNA, and type II Glanzmann's thrombasthenia.Q44518825
Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteinsQ44956435
Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling.Q45227038
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.Q45986472
LAD-1/variant syndrome is caused by mutations in FERMT3.Q46209404
Cellular invasion by Staphylococcus aureus reveals a functional link between focal adhesion kinase and cortactin in integrin-mediated internalisationQ46458595
SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell functionQ46458771
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)273-288
P577publication date2014-04-01
P1433published inNature Reviews Molecular Cell BiologyQ1573120
P1476titleThe integrin adhesome: from genes and proteins to human disease
P478volume15

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Q38622448Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction
Q37421179Scale Invariant Disordered Nanotopography Promotes Hippocampal Neuron Development and Maturation with Involvement of Mechanotransductive Pathways.
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Q41852634Simple and complex retinal dystrophies are associated with profoundly different disease networks
Q30670203Structural and functional analysis of cell adhesion and nuclear envelope nano-topography in cell death
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Q48032625Structural basis of kindlin-mediated integrin recognition and activation.
Q38870776Structured illumination microscopy reveals focal adhesions are composed of linear subunits.
Q90591291Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions
Q39431307Talin - the master of integrin adhesions.
Q57446958Talin as a mechanosensitive signaling hub
Q50345398Talin gets SHANKed in the fight for integrin activation.
Q55260595Teaming Up for Trouble: Cancer Cells, Transforming Growth Factor-β1 Signaling and the Epigenetic Corruption of Stromal Naïve Fibroblasts.
Q57497858Techniques to stimulate and interrogate cell-cell adhesion mechanics
Q38966462The Cohesive Metastasis Phenotype in Human Prostate Cancer
Q64253785The Crosstalk Between Cell Adhesion and Cancer Metabolism
Q50231801The Evolving Complexity of the Podocyte Cytoskeleton
Q89660060The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression
Q33790864The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier
Q49176545The Possible Importance of β3 Integrins for Leukemogenesis and Chemoresistance in Acute Myeloid Leukemia
Q46062672The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton.
Q39046463The cancer cell adhesion resistome: mechanisms, targeting and translational approaches
Q38263509The importance of podocyte adhesion for a healthy glomerulus
Q28077380The integrin adhesome network at a glance
Q50658719The molecular clutch model for mechanotransduction evolves.
Q90212338The role of integrins in melanoma: a review
Q26778616The role of the Src Homology-2 domain containing protein B (SHB) in β cells
Q88557112The tale of two talins - two isoforms to fine-tune integrin signalling
Q39115388Three-Dimensional Localization of Single Molecules for Super-Resolution Imaging and Single-Particle Tracking
Q87906856Tracking fast cellular membrane dynamics with sub-nm accuracy in the normal direction
Q35408783Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant
Q90478015Tumor endothelial marker 8 promotes cancer progression and metastasis
Q41362701Viable phenotype of ILNEB syndrome without nephrotic impairment in siblings heterozygous for unreported integrin alpha3 mutations.
Q58614127Wound healing mechanism in Mongolian gerbil skin
Q50985108c-Met and Other Cell Surface Molecules: Interaction, Activation and Functional Consequences.
Q37622390αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin.
Q38852942αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating
Q26774789β1 Integrins as Therapeutic Targets to Disrupt Hallmarks of Cancer

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