p53 isoform delta113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish.

scientific article published on February 2009

p53 isoform delta113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1101/GAD.1761609
P932PMC publication ID2648546
P698PubMed publication ID19204115
P5875ResearchGate publication ID247610277

P50authorDavid P. LaneQ909289
Jean-Christophe BourdonQ56809446
Jinrong PengQ37374467
P2093author name stringJun Chen
Zhenhai Zhang
Sok Meng Ng
Changqing Chang
P2860cites workHuman delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.Q53393697
Further characterisation of the p53 responsive element--identification of new candidate genes for trans-activation by p53Q73016679
p53 activation by knockdown technologiesQ21563456
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activitiesQ22003973
p53 isoforms can regulate p53 transcriptional activity.Q24319034
Surfing the p53 networkQ28032484
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivationQ28280958
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53Q29617850
On the road to cancer: aneuploidy and the mitotic checkpointQ29619455
p53 in health and diseaseQ29619939
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumorsQ33722903
The p53MH algorithm and its application in detecting p53-responsive genesQ34064408
Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish.Q34227075
Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.Q34443272
P53 is a tumor suppressor geneQ34546732
Detection of the p53 response in zebrafish embryos using new monoclonal antibodiesQ34660684
Analysis of p53-regulated gene expression patterns using oligonucleotide arraysQ35191756
Transcriptional regulation by p53: one protein, many possibilitiesQ36436698
The complexity of p53 stabilization and activationQ36443523
Expression of novel p53 isoforms in oral lichen planusQ37214807
Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrestQ37606164
HNF factors form a network to regulate liver-enriched genes in zebrafishQ38314020
Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signalingQ40616229
Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesisQ40694250
Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?Q41513765
Expression of p53 isoforms in squamous cell carcinoma of the head and neckQ42412666
Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate developmentQ44638792
Functional characterization of the Bcl-2 gene family in the zebrafish.Q47073936
P433issue3
P921main subjectapoptotic processQ14599311
Danio rerioQ169444
P304page(s)278-290
P577publication date2009-02-01
P1433published inGenes & DevelopmentQ1524533
P1476titlep53 isoform delta113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish
P478volume23

Reverse relations

cites work (P2860)
Q49679572A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation
Q89543043A mouse model of the Δ133p53 isoform: roles in cancer progression and inflammation
Q35098047A naturally occurring 4-bp deletion in the intron 4 of p53 creates a spectrum of novel p53 isoforms with anti-apoptosis function.
Q38179828Alternative splicing in cancer: implications for biology and therapy
Q47073552An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish
Q35999365An equation to estimate the difference between theoretically predicted and SDS PAGE-displayed molecular weights for an acidic peptide
Q35546335Biological functions of p53 isoforms through evolution: lessons from animal and cellular models.
Q36292356CCAAT/enhancer-binding protein α is required for hepatic outgrowth via the p53 pathway in zebrafish
Q91697506Cdc20 and molecular chaperone CCT2 and CCT5 are required for the Muscovy duck reovirus p10.8-induced cell cycle arrest and apoptosis
Q37465858Cnbp ameliorates Treacher Collins Syndrome craniofacial anomalies through a pathway that involves redox-responsive genes
Q54566271Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia.
Q26775866DNA repair and aging: the impact of the p53 family
Q37418067Damage-inducible intragenic demethylation of the human TP53 tumor suppressor gene is associated with transcription from an alternative intronic promoter.
Q33112706Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation
Q43175897DeltaN133p53 expression levels in relation to haplotypes of the TP53 internal promoter region
Q39236844Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis
Q33712449Differential regulation of p53 function by the N-terminal ΔNp53 and Δ113p53 isoforms in zebrafish embryos
Q52827232Discovery of TP53 splice variants in two novel papillary urothelial cancer cell lines.
Q39444688Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity
Q36473588Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation
Q37272473Dynamic regulation of the transcription initiation landscape at single nucleotide resolution during vertebrate embryogenesis
Q89058816Elevation of the TP53 isoform Δ133p53β in glioblastomas: an alternative to mutant p53 in promoting tumor development
Q90975576Functional interplay between p53 and Δ133p53 in adaptive stress response
Q39249666INMAP, a novel truncated version of POLR3B, represses AP-1 and p53 transcriptional activity
Q34496963Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival
Q40991008Identification of p53-target genes in Danio rerio
Q37720213Increased Δ133p53 mRNA in lung carcinoma corresponds with reduction of p21 expression
Q41660631Induced Pluripotent Stem Cells: Advances in the Quest for Genetic Stability during Reprogramming Process
Q36172140Influenza A viruses control expression of proviral human p53 isoforms p53β and Delta133p53α.
Q50421956Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus.
Q37524738Liver development in zebrafish (Danio rerio).
Q35930935Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish
Q37612647Minor class splicing shapes the zebrafish transcriptome during development
Q35925596Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction.
Q38338300Nusap1 is essential for neural crest cell migration in zebrafish
Q38961305Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene
Q28554321Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3
Q35680232Ribosomal Protein Mutations Result in Constitutive p53 Protein Degradation through Impairment of the AKT Pathway
Q36144962Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development
Q41450780SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway.
Q47073812Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish
Q43286701Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish
Q34979878Splice-acceptor site mutation in p53 gene of hu888 zebrafish line.
Q34234217TP53 status for prediction of sensitivity to taxane versus non-taxane neoadjuvant chemotherapy in breast cancer (EORTC 10994/BIG 1-00): a randomised phase 3 trial
Q91966464The Emerging Landscape of p53 Isoforms in Physiology, Cancer and Degenerative Diseases
Q37741331The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger.
Q24298743The RNA helicase p68 modulates expression and function of the Δ133 isoform(s) of p53, and is inversely associated with Δ133p53 expression in breast cancer
Q35856958The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish
Q61451282The effector of Hippo signaling, Taz, is required for formation of the micropyle and fertilization in zebrafish
Q36751520The function of Drosophila p53 isoforms in apoptosis
Q33693832The isoforms of the p53 protein
Q37727630The nuclear pore complex function of Sec13 protein is required for cell survival during retinal development
Q36284222The p53 isoform delta133p53ß regulates cancer cell apoptosis in a RhoB-dependent manner
Q39325284The p53 isoform, Δ133p53α, stimulates angiogenesis and tumour progression.
Q39367419The p53 isoforms are differentially modified by Mdm2.
Q92735009The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer
Q37746500Tied up in loops: positive and negative autoregulation of p53.
Q52715468Tolerance to paternal genotoxic damage promotes survival during embryo development in zebrafish (Danio rerio).
Q34100529Tracing the protectors path from the germ line to the genome
Q33721932Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish
Q33584237Zebrafish have a competent p53-dependent nucleotide excision repair pathway to resolve ultraviolet B-induced DNA damage in the skin
Q34014685Zebrafish models of p53 functions
Q21135272liver-enriched gene 1a and 1b encode novel secretory proteins essential for normal liver development in zebrafish
Q58702684p53 Isoforms and Their Implications in Cancer
Q34202703p53 Isoforms: An Intracellular Microprocessor?
Q38708506p53 Isoforms: Key Regulators of the Cell Fate Decision.
Q64991984p53 and its isoforms in DNA double-stranded break repair.
Q42397498p53 coordinates with Δ133p53 isoform to promote cell survival under low-level oxidative stress
Q34575503p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage
Q97681137p53 isoform Δ113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis
Q35146231p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage
Q37428226p53 isoform Δ133p53 promotes efficiency of induced pluripotent stem cells and ensures genomic integrity during reprogramming
Q33576299p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence
Q35029530p53 mutant breast cancer patients expressing p53γ have as good a prognosis as wild-type p53 breast cancer patients.
Q38987401p53 on the crossroad between regeneration and cancer
Q34671832p53 protein isoforms: key regulators in the front line of pathogen infections?
Q39734003p53 regulates the transcription of its Delta133p53 isoform through specific response elements contained within the TP53 P2 internal promoter
Q52671036p73 coordinates with Δ133p53 to promote DNA double-strand break repair.
Q40630635Δ113p53/Δ133p53 converts P53 from a repressor to a promoter of DNA double-stand break repair
Q42746620Δ113p53/Δ133p53: survival and integrity
Q38864733Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant
Q35623109Δ133p53 is an independent prognostic marker in p53 mutant advanced serous ovarian cancer
Q55424605Δ133p53α, a natural p53 isoform, contributes to conditional reprogramming and long-term proliferation of primary epithelial cells.
Q42862265Δ160p53 is a novel N-terminal p53 isoform encoded by Δ133p53 transcript.

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