Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5.

scientific article

Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.00663-07
P932PMC publication ID1951445
P698PubMed publication ID17553882
P5875ResearchGate publication ID6282702

P50authorSimon N. WaddingtonQ37835224
John H. McVeyQ40442623
Alan L ParkerQ55324134
Stuart A NicklinQ55859805
Suzanne M BuckleyQ58227963
P2093author name stringAndrew H Baker
Menzo Havenga
P2860cites workThe coxsackievirus and adenovirus receptor is a transmembrane component of the tight junctionQ24291966
HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackievirusesQ24312224
Adenovirus Binding to Blood Factors Results in Liver Cell Infection and HepatotoxicityQ27469833
Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5Q28303765
Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachmentQ29615852
Exploiting the natural diversity in adenovirus tropism for therapy and prevention of diseaseQ30830095
Long-term stable correction of low-density lipoprotein receptor-deficient mice with a helper-dependent adenoviral vector expressing the very low-density lipoprotein receptorQ32129558
Reducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactionsQ33849565
The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors.Q35899034
The influence of adenovirus fiber structure and function on vector development for gene therapyQ36182171
Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytesQ40264847
Adenovirus type 5 interactions with human blood cells may compromise systemic delivery.Q40297306
Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in ratsQ40528538
Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivoQ40782543
Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D.Q41900381
A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivoQ42833222
The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants.Q44717204
Rapid Kupffer cell death after intravenous injection of adenovirus vectorsQ45119497
Titer determination of Ad5 in blood: a cautionary noteQ45862533
CD46 is a cellular receptor for group B adenovirusesQ45869560
Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liverQ45874045
Bioluminescence imaging reveals a significant role for complement in liver transduction following intravenous delivery of adenovirusQ45877055
Targeting of adenovirus vectors to tumor cells does not enable efficient transduction of breast cancer metastasesQ64379110
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectAdenoviridaeQ193447
P304page(s)9568-9571
P577publication date2007-06-06
P1433published inJournal of VirologyQ1251128
P1476titleTargeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5
P478volume81

Reverse relations

cites work (P2860)
Q34701038Adrenal gland infection by serotype 5 adenovirus requires coagulation factors
Q37859842Advances and future challenges in adenoviral vector pharmacology and targeting
Q34282191Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors
Q28744246Cell entry and trafficking of human adenovirus bound to blood factor X is determined by the fiber serotype and not hexon:heparan sulfate interaction
Q50977875Challenges and Prospects for Helper-Dependent Adenoviral Vector-Mediated Gene Therapy.
Q34597583Clearance of adenovirus by Kupffer cells is mediated by scavenger receptors, natural antibodies, and complement
Q39462577Coagulation factor IX mediates serotype-specific binding of species A adenoviruses to host cells
Q39892766Coagulation factors IX and X enhance binding and infection of adenovirus types 5 and 31 in human epithelial cells
Q33440718Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum
Q35107329Differential effects of murine and human factor X on adenovirus transduction via cell-surface heparan sulfate
Q39926337Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer
Q38897929Expression of an engineered soluble coxsackievirus and adenovirus receptor by a dimeric AAV9 vector inhibits adenovirus infection in mice
Q42146790FX and host defense evasion tactics by adenovirus
Q37945218Gene therapy with helper-dependent adenoviral vectors: current advances and future perspectives
Q40119187Gene-therapy delivery strategies in cardiology
Q35086122Generation of a Kupffer cell-evading adenovirus for systemic and liver-directed gene transfer
Q37582126Helper-Dependent Adenoviral Vectors.
Q35096275Hexon modification to improve the activity of oncolytic adenovirus vectors against neoplastic and stromal cells in pancreatic cancer
Q37291653Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer
Q35641791Incorporation of Peptides Targeting EGFR and FGFR1 into the Adenoviral Fiber Knob Domain and Their Evaluation as Targeted Cancer Therapies
Q39502394Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors
Q39682767Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells
Q37984486Manipulation of adenovirus interactions with host factors for gene therapy applications
Q34667746Mutation of the fiber shaft heparan sulphate binding site of a 5/3 chimeric adenovirus reduces liver tropism
Q45879870Non-heparan sulfate GAG-dependent infection of cells using an adenoviral vector with a chimeric fiber conserving its KKTK motif.
Q26776553Oncolytic Adenovirus: Strategies and Insights for Vector Design and Immuno-Oncolytic Applications
Q37448942Oncolytic adenoviral gene therapy in ovarian cancer: why we are not wasting our time
Q92020016Patchy Amphiphilic Dendrimers Bind Adenovirus and Control Its Host Interactions and in Vivo Distribution
Q35238390Perinatal gene transfer to the liver
Q33713401Redundant and synergistic mechanisms control the sequestration of blood-born adenovirus in the liver
Q34699410Retargeting adenoviral vectors to improve gene transfer into tumors
Q39971490Substitution of hexon hypervariable region 5 of adenovirus serotype 5 abrogates blood factor binding and limits gene transfer to liver
Q35015807The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice
Q38230901The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery
Q33655401The influence of innate and pre-existing immunity on adenovirus therapy
Q39669977The liver as a target organ for gene therapy: state of the art, challenges, and future perspectives
Q37641568The role of liver sinusoidal cells in hepatocyte-directed gene transfer
Q36955901Therapeutic potential of replication-selective oncolytic adenoviruses on cells from familial and sporadic desmoid tumors
Q28539158Traceless bioresponsive shielding of adenovirus hexon with HPMA copolymers maintains transduction capacity in vitro and in vivo
Q38614156Tropism-modification strategies for targeted gene delivery using adenoviral vectors
Q33586303Vector and helper genome rearrangements occur during production of helper-dependent adenoviral vectors
Q37087304With a little help from my f(X)riends!: the basis of Ad5-mediated transduction of the liver revealed

Search more.