Evidence of CD8+ T-cell-mediated selective pressure on human immunodeficiency virus type 1 nef in HLA-B*57+ elite suppressors

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Evidence of CD8+ T-cell-mediated selective pressure on human immunodeficiency virus type 1 nef in HLA-B*57+ elite suppressors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.01958-08
P8608Fatcat IDrelease_tcw6qr33wra2rh54blyijeb2uu
P932PMC publication ID2612327
P698PubMed publication ID18945771
P5875ResearchGate publication ID23409548

P50authorRobert F. SilicianoQ7344216
P2093author name stringJoel N Blankson
Justin R Bailey
Karen A O'Connell
Timothy P Brennan
P2860cites workVirus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infectionQ24645815
Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndromeQ24648628
HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressorsQ24676982
RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed modelsQ27860746
A rapid bootstrap algorithm for the RAxML Web serversQ27860864
TreeView: an application to display phylogenetic trees on personal computersQ27861074
A whole-genome association study of major determinants for host control of HIV-1Q29614891
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cellsQ29616205
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytesQ29616210
Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaquesQ33781916
Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infectionQ33987347
Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.Q34009945
The differential ability of HLA B*5701+ long-term nonprogressors and progressors to restrict human immunodeficiency virus replication is not caused by loss of recognition of autologous viral gag sequencesQ34200151
HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replicationQ34448446
Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1Q34545760
Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type 1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapyQ34647680
Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnoverQ34692601
Transmission of human immunodeficiency virus type 1 from a patient who developed AIDS to an elite suppressorQ34780395
Potential applications and pitfalls of Bayesian inference of phylogenyQ34978896
HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotypeQ35749755
Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replicationQ35785115
Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutationsQ36238124
Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.Q36315572
Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.Q36368095
Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.Q36403330
Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing childQ36684112
Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changesQ36845893
A comparison of viral loads between HIV-1-infected elite suppressors and individuals who receive suppressive highly active antiretroviral therapyQ36931169
HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus controlQ38610690
Biological characterization of nef in long-term survivors of human immunodeficiency virus type 1 infectionQ39872863
Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.Q41827503
The role of protective HCP5 and HLA-C associated polymorphisms in the control of HIV-1 replication in a subset of elite suppressorsQ43582696
Evolution of HIV-1 in an HLA-B*57-positive patient during virologic escape.Q44082963
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.Q44291572
HIV evolution: CTL escape mutation and reversion after transmissionQ47211742
HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.Q53671883
Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytesQ57075675
CD8+ T-cell responses to different HIV proteins have discordant associations with viral loadQ57259602
Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDSQ73034306
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressorsQ78342521
A nonprogressive clinical course in HIV-infected individuals expressing human leukocyte antigen B57/5801 is associated with preserved CD8+ T lymphocyte responsiveness to the HW9 epitope in NefQ80714316
Viral replication capacity as a correlate of HLA B57/B5801-associated nonprogressive HIV-1 infectionQ80819695
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)88-97
P577publication date2008-10-22
P1433published inJournal of VirologyQ1251128
P1476titleEvidence of CD8+ T-cell-mediated selective pressure on human immunodeficiency virus type 1 nef in HLA-B*57+ elite suppressors
P478volume83

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cites work (P2860)
Q92132702A T Cell Receptor Sequencing-Based Assay Identifies Cross-Reactive Recall CD8+ T Cell Clonotypes Against Autologous HIV-1 Epitope Variants
Q33815728A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers
Q41868799Attenuation of multiple Nef functions in HIV-1 elite controllers
Q37547677Both HLA-B*57 and plasma HIV RNA levels contribute to the HIV-specific CD8+ T cell response in HIV controllers
Q35216907CD4+ T cells from elite suppressors are more susceptible to HIV-1 but produce fewer virions than cells from chronic progressors
Q37427587CD8+ T cells from HLA-B*57 elite suppressors effectively suppress replication of HIV-1 escape mutants
Q38748887Circulating monocytes are not a major reservoir of HIV-1 in elite suppressors
Q52625002Control of HIV-1 Pathogenesis in Viremic Nonprogressors Is Independent of Gag-Specific Cytotoxic T Lymphocyte Responses.
Q42737606Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virus
Q38032363Developing strategies for HIV-1 eradication
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Q35001377Effector mechanisms in HIV-1 infected elite controllers: highly active immune responses?
Q42115872Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages.
Q36148988Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite Controllers
Q33839450Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART.
Q41444622Evolution of the HIV-1 nef gene in HLA-B*57 positive elite suppressors
Q47174478Factors Leading to the Loss of Natural Elite Control of HIV-1 Infection.
Q34284388Glycoproteomic study reveals altered plasma proteins associated with HIV elite suppressors
Q38045636HIV and HLA class I: an evolving relationship
Q38637864HIV-1 reservoirs in elite controllers: clues for developing a functional cure?
Q34699130HIV-specific CD4+ T cells may contribute to viral persistence in HIV controllers
Q37643772HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice
Q37127920HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers
Q34984762Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses
Q34699353Impaired memory CD8 T cell responses against an immunodominant retroviral cryptic epitope
Q64108832Induction and maintenance of bi-functional (IFN-γ + IL-2+ and IL-2+ TNF-α+) T cell responses by DNA prime MVA boosted subtype C prophylactic vaccine tested in a Phase I trial in India
Q92511404Learning From the Exceptions: HIV Remission in Post-treatment Controllers
Q37183848Mechanisms of HIV-1 Nef function and intracellular signaling
Q34984237Nef-specific CD8+ T cell responses contribute to HIV-1 immune control
Q58755453Next-generation sequencing analyses of the emergence and maintenance of mutations in CTL epitopes in HIV controllers with differential viremia control
Q34056881Polymorphisms in toll-like receptor 4 and toll-like receptor 9 influence viral load in a seroincident cohort of HIV-1-infected individuals
Q41915015Primary CD8+ T cells from elite suppressors effectively eliminate non-productively HIV-1 infected resting and activated CD4+ T cells
Q34746588Spontaneous control of HIV-1 viremia in a subject with protective HLA-B plus HLA-C alleles and HLA-C associated single nucleotide polymorphisms.
Q35737580Survival and HLA-B*57 in HIV/HCV Co-Infected Patients on Highly Active Antiretroviral Therapy (HAART).
Q38032153The implications of viral reservoirs on the elite control of HIV-1 infection
Q37325420Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study
Q38116710Unravelling the mechanisms of durable control of HIV-1.
Q38425723Viral suppression of multiple escape mutants by de novo CD8(+) T cell responses in a human immunodeficiency virus-1 infected elite suppressor

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