Circulating monocytes are not a major reservoir of HIV-1 in elite suppressors

scientific article published on 27 July 2011

Circulating monocytes are not a major reservoir of HIV-1 in elite suppressors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.05409-11
P932PMC publication ID3196433
P698PubMed publication ID21795348

P50authorAdam M SpivakQ56863030
P2093author name stringS Alireza Rabi
Joel N Blankson
Karen A O'Connell
Maria Salgado
P2860cites workThe CD16+ Monocyte Subset Is More Permissive to Infection and Preferentially Harbors HIV-1 In VivoQ58003915
Kinetics of human monocytopoiesisQ68828097
The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4Q69518980
Observations on human monocyte kinetics after pulse labelingQ70420450
Monocyte kinetics: Observations after pulse labelingQ72138869
Macrophages as a source of HIV during opportunistic infectionsQ73427586
Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cellsQ24548940
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapyQ28253761
Compartmentalized human immunodeficiency virus type 1 originates from long-lived cells in some subjects with HIV-1-associated dementiaQ28475360
Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapyQ29615992
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapyQ29615993
Recovery of replication-competent HIV despite prolonged suppression of plasma viremiaQ29615995
The role of mononuclear phagocytes in HTLV-III/LAV infectionQ29618676
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infectionQ29619738
CCR5 expression correlates with susceptibility of maturing monocytes to human immunodeficiency virus type 1 infectionQ33782193
Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART.Q33839450
Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineageQ33864438
Latent HIV-1 infection in enriched populations of blood monocytes and T cells from seropositive patientsQ34174396
Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllersQ34189960
HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replicationQ34448446
Infection of monocyte/macrophages by human T lymphotropic virus type III.Q34579117
Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type 1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapyQ34647680
Elucidating the elite: mechanisms of control in HIV-1 infectionQ35008384
The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infectionQ35213775
Activation of infectious virus from latent human immunodeficiency virus infection of monocytes in vivoQ35607138
Compartmentalization of human immunodeficiency virus type 1 between blood monocytes and CD4+ T cells during infectionQ35704022
Human immunodeficiency virus type 1 replication is blocked prior to reverse transcription and integration in freshly isolated peripheral blood monocytesQ35861719
Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutationsQ36238124
Migratory fate and differentiation of blood monocyte subsetsQ36571680
Characterization of the early steps of infection of primary blood monocytes by human immunodeficiency virus type 1Q36748024
Blood monocytes from most human immunodeficiency virus type 1-infected patients do not carry proviral DNA.Q36930987
Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapyQ37033224
Cellular reservoirs of HIV-1 and their role in viral persistenceQ37196089
HIV-1 regulation of latency in the monocyte-macrophage lineage and in CD4+ T lymphocytesQ37607912
Characterization of restrictions to human immunodeficiency virus type 1 infection of monocytesQ37730431
Progression of HIV-1 infection. Monitoring of HIV-1 DNA in peripheral blood mononuclear cells by PCR.Q39085541
Detection of HIV-1 DNA in different subsets of human peripheral blood mononuclear cells using the polymerase chain reaction. Rapid communicationQ39085545
Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers.Q39112993
Unstimulated Primary CD4 + T Cells from HIV-1-Positive Elite Suppressors Are Fully Susceptible to HIV-1 Entry and Productive InfectionQ39376055
Macrophage-tropic HIV-1 variants: initiators of infection and AIDS pathogenesis?Q39439702
Postentry restriction to human immunodeficiency virus-based vector transduction in human monocytesQ39602905
Evidence for human immunodeficiency virus type 1 replication in vivo in CD14(+) monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapyQ39685944
Kinetics of human immunodeficiency virus type 1 reverse transcription in blood mononuclear phagocytes are slowed by limitations of nucleotide precursorsQ40039220
Persistence of distinct HIV-1 populations in blood monocytes and naive and memory CD4 T cells during prolonged suppressive HAART.Q40380996
HIV-1 in blood monocytes: frequency of detection of proviral DNA using PCR and comparison with the total CD4 countQ41642433
Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1.Q41710744
Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.Q41827503
Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytesQ41994305
Evidence of CD8+ T-cell-mediated selective pressure on human immunodeficiency virus type 1 nef in HLA-B*57+ elite suppressorsQ42155467
Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virusQ42737606
Human immunodeficiency virus type I provirus is demonstrated in peripheral blood monocytes in vivo: a study utilizing an in situ polymerase chain reactionQ45774080
Virus isolation from and identification of HTLV-III/LAV-producing cells in brain tissue from a patient with AIDS.Q45831294
Analysis of lymphocytes, monocytes, and neutrophils from human immunodeficiency virus (HIV)-infected persons for HIV DNA.Q45853476
Multiplication of human immunodeficiency virus in primary cultures of human kupffer cells—possible role of liver macrophage infection in the physiopathology of aidsQ45860271
HIV-1 compartmentalization in diverse leukocyte populations during antiretroviral therapyQ47289409
Persistence of neuropsychologic deficits despite long-term highly active antiretroviral therapy in patients with HIV-related neurocognitive impairment: prevalence and risk factorsQ48244275
A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes.Q50498229
Monocytes harbour replication-competent, non-latent HIV-1 in patients on highly active antiretroviral therapy.Q52021616
Detection of infectious HIV in circulating monocytes from patients on prolonged highly active antiretroviral therapy.Q54057499
Comparative Analysis of Total and Integrated HIV-1 DNA in Peripheral CD4 Lymphocytes and Monocytes After Long Treatment with HAARTQ56424819
HIV-1 DNA and mRNA concentrations are similar in peripheral blood monocytes and alveolar macrophages in HIV-1-infected individualsQ57235641
P433issue19
P407language of work or nameEnglishQ1860
P1104number of pages5
P304page(s)10399-10403
P577publication date2011-07-27
P1433published inJournal of VirologyQ1251128
P1476titleCirculating monocytes are not a major reservoir of HIV-1 in elite suppressors
P478volume85

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cites work (P2860)
Q37024994Antiretroviral monocyte efficacy score linked to cognitive impairment in HIV.
Q35408098Differential levels of soluble inflammatory markers by human immunodeficiency virus controller status and demographics
Q35544355Eradication of HIV-1 from the macrophage reservoir: an uncertain goal?
Q35196509HIV-1 target cells in the CNS.
Q34341835Intracellular overexpression of HIV-1 Nef impairs differentiation and maturation of monocytic precursors towards dendritic cells
Q36737917Macrophages sustain HIV replication in vivo independently of T cells
Q40354310Monocyte-lymphocyte fusion induced by the HIV-1 envelope generates functional heterokaryons with an activated monocyte-like phenotype
Q41915015Primary CD8+ T cells from elite suppressors effectively eliminate non-productively HIV-1 infected resting and activated CD4+ T cells
Q35799435Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patients
Q41880147Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.
Q91811483The HIV Reservoir in Monocytes and Macrophages
Q42160092The Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents
Q38032153The implications of viral reservoirs on the elite control of HIV-1 infection
Q43505499The importance of monocytes and macrophages in HIV pathogenesis, treatment, and cure.