The Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents

scientific article published on July 2012

The Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2012/625983
P932PMC publication ID3395185
P698PubMed publication ID22811909
P5875ResearchGate publication ID229327199

P50authorRaymond F. SchinaziQ7298769
Christina GavegnanoQ125272221
P2093author name stringBaek Kim
Edward M Kennedy
P2860cites workMutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune responseQ24338296
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by VpxQ24605940
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphatesQ24624362
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 proteinQ24635842
Monocytes harbour replication-competent, non-latent HIV-1 in patients on highly active antiretroviral therapy.Q52021616
Rapid MHC-II antigen presentation of HIV type 1 by human dendritic cells.Q53543523
The CD16+ Monocyte Subset Is More Permissive to Infection and Preferentially Harbors HIV-1 In VivoQ58003915
Assessing the relative efficacy of antiretroviral activity of different drugs on macrophagesQ80977227
CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1Q28646859
Monocyte/macrophage trafficking in acquired immunodeficiency syndrome encephalitis: lessons from human and nonhuman primate studiesQ28751900
Physiological concentrations of purines and pyrimidinesQ29616721
A flexible model of HIV-1 latency permitting evaluation of many primary CD4 T-cell reservoirsQ34145909
Antiretroviral therapy in macrophages: implication for HIV eradicationQ34298792
Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptaseQ34313399
Ribonucleoside triphosphates as substrate of human immunodeficiency virus type 1 reverse transcriptase in human macrophagesQ34386057
Macrophages: a crucial reservoir for human immunodeficiency virus in the body.Q34427702
Mutagenicity and pausing of HIV reverse transcriptase during HIV plus-strand DNA synthesisQ34798628
Pulsed stable isotope labeling of amino acids in cell culture uncovers the dynamic interactions between HIV-1 and the monocyte-derived macrophageQ35025824
The influence of cytokines, chemokines and their receptors on HIV-1 replication in monocytes and macrophages.Q35040074
Abundant non-canonical dUTP found in primary human macrophages drives its frequent incorporation by HIV-1 reverse transcriptaseQ35107515
Monocyte/macrophage traffic in HIV and SIV encephalitisQ35213772
Human immunodeficiency virus infects human seminal vesicles in vitro and in vivoQ35474074
Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaquesQ35484743
The changes in the T helper 1 (Th1) and T helper 2 (Th2) cytokine balance during HIV-1 infection are indicative of an allergic response to viral proteins that may be reversed by Th2 cytokine inhibitors and immune response modifiers--a review and hypQ35636412
Antiretroviral monocyte efficacy score linked to cognitive impairment in HIV.Q37024994
Cellular reservoirs of HIV-1 and their role in viral persistenceQ37196089
Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methylguanine and O(6)-benzylguanineQ38292985
Mechanistic studies of early pausing events during initiation of HIV-1 reverse transcriptionQ38334633
Simultaneous quantification of intracellular natural and antiretroviral nucleosides and nucleotides by liquid chromatography-tandem mass spectrometryQ38583674
Circulating monocytes are not a major reservoir of HIV-1 in elite suppressorsQ38748887
Evidence for human immunodeficiency virus type 1 replication in vivo in CD14(+) monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapyQ39685944
Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virusQ40037960
Failure to clear intra-monocyte HIV infection linked to persistent neuropsychological testing impairment after first-line combined antiretroviral therapyQ42130105
Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophagesQ43664017
Long-term survival and virus production in human primary macrophages infected by human immunodeficiency virusQ44177453
Modification of human immunodeficiency virus type 1 reverse transcriptase to target cells with elevated cellular dNTP concentrationsQ45419490
T lymphocytes and macrophages, but not motile spermatozoa, are a significant source of human immunodeficiency virus in semenQ45760106
Analysis of nucleotide insertion and extension at 8-oxo-7,8-dihydroguanine by replicative T7 polymerase exo- and human immunodeficiency virus-1 reverse transcriptase using steady-state and pre-steady-state kineticsQ45762771
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P304page(s)625983
P577publication date2012-07-01
P1433published inMolecular Biology InternationalQ26841791
P1476titleThe Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents
P478volume2012

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cites work (P2860)
Q42152706AZT resistance alters enzymatic properties and creates an ATP-binding site in SFVmac reverse transcriptase
Q36081148Alterations in P-Glycoprotein Expression and Function Between Macrophage Subsets
Q34632979Anti-tat Hutat2:Fc mediated protection against tat-induced neurotoxicity and HIV-1 replication in human monocyte-derived macrophages
Q41451997Cellular pharmacology and potency of HIV-1 nucleoside analogs in primary human macrophages
Q58092929Differential extracellular, but similar intracellular, disposition of two tenofovir formulations in the male genital tract
Q37270321Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells.
Q33606917GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state
Q38773755Human Immunodeficiency Virus Infection and Host Defense in the Lungs
Q21245040Identification and characterization of naturally occurring splice variants of SAMHD1
Q42176551Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses
Q36086379Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+ T Cell Killing
Q37311408Restricted 5'-end gap repair of HIV-1 integration due to limited cellular dNTP concentrations in human primary macrophages
Q90609678Seminal Tenofovir Concentrations, Viral Suppression, and Semen Quality With Tenofovir Alafenamide, Compared With Tenofovir Disoproxil Fumarate (Spanish HIV/AIDS Research Network, PreEC/RIS 40)
Q38290524Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer
Q26823236The macrophage: a therapeutic target in HIV-1 infection
Q27698300The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP
Q64971881Transcriptional Profiling Suggests Extensive Metabolic Rewiring of Human and Mouse Macrophages during Early Interferon Alpha Responses.

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