Mutations in nsP1 and PE2 are critical determinants of Ross River virus-induced musculoskeletal inflammatory disease in a mouse model

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Mutations in nsP1 and PE2 are critical determinants of Ross River virus-induced musculoskeletal inflammatory disease in a mouse model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VIROL.2010.11.012
P932PMC publication ID3017666
P698PubMed publication ID21131014
P5875ResearchGate publication ID49657745

P50authorSuresh MahalingamQ55190793
Mark T HeiseQ89544238
Bronwyn M GunnQ91842985
P2093author name stringThomas E Morrison
Lauren Oko
Kristina A Stoermer
Henri J Jupille
P2860cites workPost-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month periodQ21562272
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Molecular defects caused by temperature-sensitive mutations in Semliki Forest virus nsP1.Q39966072
The 3' untranslated region of sindbis virus represses deadenylation of viral transcripts in mosquito and Mammalian cellsQ40058120
Specific restrictions in the progression of Venezuelan equine encephalitis virus-induced disease resulting from single amino acid changes in the glycoproteinsQ41372385
The Semliki Forest virus E2 gene as a virulence determinantQ41390376
SVLM21, a Sindbis virus mutant resistant to methionine deprivation, encodes an altered methyltransferaseQ41759394
Association of the Sindbis virus RNA methyltransferase activity with the nonstructural protein nsP1.Q42990081
Complement receptor 3 promotes severe ross river virus-induced diseaseQ43251027
The effects of palmitoylation on membrane association of Semliki forest virus RNA capping enzymeQ43828148
A single amino acid change in the E2 spike protein of a virulent strain of Semliki Forest virus attenuates pathogenicityQ43935939
Persistent arthralgia associated with chikungunya virus: a study of 88 adult patients on reunion islandQ44851009
Chikungunya virus infection. A retrospective study of 107 casesQ44851815
Mutations in the E2 glycoprotein of Venezuelan equine encephalitis virus confer heparan sulfate interaction, low morbidity, and rapid clearance from blood of miceQ45740291
Detection of viral ribonucleic acid and histologic analysis of inflamed synovium in Ross River virus infectionQ45744149
Regions of conservation and divergence in the 3' untranslated sequences of genomic RNA from Ross River virus isolatesQ45835560
Attenuating mutations in the E2 glycoprotein gene of Venezuelan equine encephalitis virus: construction of single and multiple mutants in a full-length cDNA cloneQ45852646
Role of the immune response in recovery from Sindbis virus encephalitis in miceQ45888076
The 3′-non-coding regions of alpharivus RNAs contain repeating sequencesQ48404949
The inflammatory response in the synovium of a patient with Ross River arbovirus infectionQ70108598
Cytology of synovial effusions in epidemic polyarthritisQ72017299
Human muscle satellite cells as targets of Chikungunya virus infectionQ21562321
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Ross River virus transmission, infection, and disease: a cross-disciplinary reviewQ24550672
Complement contributes to inflammatory tissue destruction in a mouse model of Ross River virus-induced diseaseQ24682922
Effects of palmitoylation of replicase protein nsP1 on alphavirus infectionQ27469680
Structural and Nonstructural Protein Genome Regions of Eastern Equine Encephalitis Virus Are Determinants of Interferon Sensitivity and Murine VirulenceQ27485898
Sindbis virus mutations which coordinately affect glycoprotein processing, penetration, and virulence in miceQ27486522
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An outbreak of Mayaro virus disease in Belterra, Brazil. I. Clinical and virological findings.Q33476749
Identification of adult mouse neurovirulence determinants of the Sindbis virus strain AR86.Q33707401
The use of chimeric Venezuelan equine encephalitis viruses as an approach for the molecular identification of natural virulence determinantsQ33803773
Replicase complex genes of Semliki Forest virus confer lethal neurovirulenceQ33804386
Role of alpha/beta interferon in Venezuelan equine encephalitis virus pathogenesis: effect of an attenuating mutation in the 5' untranslated regionQ33851223
Factors associated with persistence of arthralgia among Chikungunya virus-infected travellers: report of 42 French casesQ34087571
Persistent chronic inflammation and infection by Chikungunya arthritogenic alphavirus in spite of a robust host immune responseQ34110965
O'NYONG-NYONG FEVER: AN EPIDEMIC VIRUS DIESEASE IN EAST AFRICA. VII. VIRUS ISOLATIONS FROM MAN AND SEROLOGICAL STUDIES UP TO JULY 1961.Q34260112
Characterization of Ross River virus tropism and virus-induced inflammation in a mouse model of viral arthritis and myositisQ34301840
A single mutation in the E2 glycoprotein important for neurovirulence influences binding of sindbis virus to neuroblastoma cellsQ34340083
Roles of nonstructural protein nsP2 and Alpha/Beta interferons in determining the outcome of Sindbis virus infectionQ34355773
Chikungunya infection: an emerging rheumatism among travelers returned from Indian Ocean islands. Report of 47 casesQ34579545
Macrophage-derived proinflammatory factors contribute to the development of arthritis and myositis after infection with an arthrogenic alphavirusQ34773767
Reaction in alphavirus mRNA capping: formation of a covalent complex of nonstructural protein nsP1 with 7-methyl-GMP.Q34775056
Novel chikungunya virus variant in travelers returning from Indian Ocean islandsQ35792249
Amino acid changes in the Sindbis virus E2 glycoprotein that increase neurovirulence improve entry into neuroblastoma cellsQ35890284
Type I interferon induction is correlated with attenuation of a South American eastern equine encephalitis virus strain in miceQ36114605
Sindbis virus nsP1 functions in negative-strand RNA synthesisQ36680703
Mechanism of altered Sindbis virus neurovirulence associated with a single-amino-acid change in the E2 Glycoprotein.Q36682697
Directed mutagenesis of a Sindbis virus pathogenesis site.Q36777364
A single nucleotide change in the E2 glycoprotein gene of Sindbis virus affects penetration rate in cell culture and virulence in neonatal miceQ37398803
Chikungunya fever: an epidemiological review of a re-emerging infectious diseaseQ37575480
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
Ross River virusQ660537
P304page(s)216-227
P577publication date2010-12-04
P1433published inVirologyQ7934867
P1476titleMutations in nsP1 and PE2 are critical determinants of Ross River virus-induced musculoskeletal inflammatory disease in a mouse model
P478volume410

Reverse relations

cites work (P2860)
Q36827438A tyrosine-to-histidine switch at position 18 of the Ross River virus E2 glycoprotein is a determinant of virus fitness in disparate hosts
Q37713542Attenuating mutations in nsP1 reveal tissue-specific mechanisms for control of Ross River virus infection
Q34378105Chronic joint disease caused by persistent Chikungunya virus infection is controlled by the adaptive immune response
Q36332866Dephosphorylation of HuR protein during alphavirus infection is associated with HuR relocalization to the cytoplasm
Q88486719Discovery and development of safe-in-man broad-spectrum antiviral agents
Q83227399Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses
Q36303514Genetic ablation of arginase 1 in macrophages and neutrophils enhances clearance of an arthritogenic alphavirus
Q60303452Increasing the Capping Efficiency of the Sindbis Virus nsP1 Protein Negatively Affects Viral Infection
Q47289858Inflammatory monocytes mediate control of acute alphavirus infection in mice.
Q38659305MUTATIONS IN THE E2 GLYCOPROTEIN AND THE 3' UNTRANSLATED REGION ENHANCE CHIKUNGUNYA VIRUS VIRULENCE IN MICE.
Q36721189Molecular determinants of mouse neurovirulence and mosquito infection for Western equine encephalitis virus
Q52561132Novel activities of safe-in-human broad-spectrum antiviral agents.
Q59000049The Pathogenesis of Alphaviruses
Q57265533The genetics of alphaviruses
Q26314703γδ T Cells Play a Protective Role in Chikungunya Virus-Induced Disease

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