Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain

scientific article published on 21 February 2017

Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1073/PNAS.1615255114
P932PMC publication ID5347560
P698PubMed publication ID28223516

P50authorYixun GengQ125271120
Shuohao SunQ125271143
Vineeta TiwariQ125271150
Pang-Yen TsengQ125271202
???Q16075062
P2093author name stringYan Wang
Junmin Peng
Qian Xu
Bo Xiao
Srinivasa N Raja
Zhe Li
Liang Han
Zhiping Wu
Qin Zheng
Anna L Blobaum
Shao-Qiu He
Vinod Tiwari
Yun Guan
Yingying Cheng
Yiyuan Cui
Corey Hopkins
Julie H Y Huang-Lionnet
P2860cites workDirect interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptorsQ24647488
Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor familyQ24681230
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Can we conquer pain?Q28211527
A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neuronsQ28215950
RNA-Seq Analysis of Human Trigeminal and Dorsal Root Ganglia with a Focus on ChemoreceptorsQ28548290
Cellular and Molecular Mechanisms of PainQ29011961
Neuronal plasticity: increasing the gain in painQ29615421
Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatmentQ30458126
A subpopulation of nociceptors specifically linked to itchQ30533337
Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRsQ30674748
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The G protein-coupled receptor subset of the rat genomeQ33300185
Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons.Q33585453
A partial L5 spinal nerve ligation induces a limited prolongation of mechanical allodynia in rats: an efficient model for studying mechanisms of neuropathic painQ33687360
Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in miceQ33923266
Mas-related G-protein–coupled receptors inhibit pathological pain in miceQ34115658
Central sensitization and LTP: do pain and memory share similar mechanisms?Q34277624
A new family of endogenous "big" Met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activityQ34281783
Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathwayQ34379315
Alternative splicing controls G protein-dependent inhibition of N-type calcium channels in nociceptorsQ34523190
Expression of voltage-gated calcium channel subunits in rat dorsal root ganglion neuronsQ74541205
Ziconotide--a novel neuron-specific calcium channel blocker for the intrathecal treatment of severe chronic pain--a short review.Q34576511
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptorQ34708055
Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1.Q34772357
BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine releaseQ35034301
The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanismsQ35798251
Voltage-gated calcium channels as targets for the treatment of chronic painQ35972024
Unmasking the tonic-aversive state in neuropathic painQ36189364
Ziconotide, an intrathecally administered N-type calcium channel antagonist for the treatment of chronic painQ36277918
Mechanisms of itch evoked by β-alanineQ36378701
The role of voltage-gated calcium channels in pain and nociceptionQ36671578
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disordersQ37360436
Block of calcium channels by enkephalin and somatostatin in neuroblastoma-glioma hybrid NG108-15 cellsQ37413178
Targeting voltage-gated calcium channels for neuropathic pain managementQ37605352
MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic painQ37622078
Temporal changes in MrgC expression after spinal nerve injuryQ37622877
Determinants of the G protein-dependent opioid modulation of neuronal calcium channelsQ37718351
What is spontaneous pain and who has it?Q38028722
Evaluation of reward from pain reliefQ38089905
A systematic review: current and future directions of dorsal root ganglion therapeutics to treat chronic painQ38117183
Calcium-permeable ion channels in pain signalingQ38175134
Sensory neuron-specific MAS-related gene-X1 receptors resist agonist-promoted endocytosisQ38344494
Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptorsQ38738222
Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trialQ39386029
Adaptive Evolution of MRG, a Neuron-Specific Gene Family Implicated in NociceptionQ40829986
Opioid therapy for chronic nonmalignant pain: a review of the critical issuesQ40943421
Modulation of Ca2+ channels by G-protein beta gamma subunitsQ41214714
Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritusQ41686577
Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neuronesQ41820930
Effect of Mas-related gene (Mrg) receptors on hyperalgesia in rats with CFA-induced inflammation via direct and indirect mechanismsQ42062642
Dynorphin A decreases voltage-dependent calcium conductance of mouse dorsal root ganglion neuronesQ43978577
Ca2+ channel inhibition by kappa opioid receptors expressed in Xenopus oocytes.Q44332960
mu-Opioid receptor-mediated reduction of neuronal calcium current occurs via a G(o)-type GTP-binding proteinQ44338763
The GTP-binding protein, Go, regulates neuronal calcium channelsQ44508440
Intrathecal, but not intravenous adenosine reduces allodynia in patients with neuropathic painQ44589931
Effect of chronic administration of morphine on the expression of bovine adrenal medulla 22-like immunoreactivity in the spinal cord of ratsQ46520803
Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons.Q47428149
Cyclic dimers of C-terminal gamma2-MSH analogs as selective antagonists of the human sensory nerve-specific receptor (SNSR-4).Q47926005
Cloning and expression of MRG receptors in macaque, mouse, and humanQ49050477
Differences in Ca2+ channels governing generation of miniature and evoked excitatory synaptic currents in spinal laminae I and II.Q51496112
The involvement of spinal bovine adrenal medulla 22-like peptide, the proenkephalin derivative, in modulation of nociceptive processing.Q53530664
Distinct mechanisms underlying pronociceptive effects of opioids.Q53690404
Dynorphin A-mediated reduction in multiple calcium currents involves a G(o) alpha-subtype G protein in rat primary afferent neuronsQ73185709
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectG protein-coupled receptorQ38173
P304page(s)E1996-E2005
P577publication date2017-02-21
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleTargeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain
P478volume114

Reverse relations

cites work (P2860)
Q92215124BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus
Q47246872Cellular and molecular mechanisms driving neuropathic pain: recent advancements and challenges
Q58104642Demethylation of G protein-coupled receptor 151 promoter facilitates the binding of Kruppel-like factor 5 and enhances neuropathic pain after nerve injury in mice
Q60907595From Synapse to Function: A Perspective on the Role of Neuroproteomics in Elucidating Mechanisms of Drug Addiction
Q55465669Involvement of MrgprC in Electroacupuncture Analgesia for Attenuating CFA-Induced Thermal Hyperalgesia by Suppressing the TRPV1 Pathway.
Q64117147Nppb Neurons Are Sensors of Mast Cell-Induced Itch
Q64944700Oligomerization of MrgC11 and μ-opioid receptors in sensory neurons enhances morphine analgesia.
Q53422317Peripherally Acting μ-Opioid Receptor Agonists Attenuate Ongoing Pain-associated Behavior and Spontaneous Neuronal Activity after Nerve Injury in Rats.

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