The role of platelets in the pathogenesis of systemic sclerosis

scientific article published on 18 June 2012

The role of platelets in the pathogenesis of systemic sclerosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FIMMU.2012.00160
P932PMC publication ID3376452
P698PubMed publication ID22719739
P5875ResearchGate publication ID227712195

P50authorPatrizia Rovere-QueriniQ62579985
P2093author name stringNorma Maugeri
Angelo A Manfredi
Maria Grazia Sabbadini
Stefano Franchini
Giuseppe A Ramirez
P2860cites workPlatelet, not endothelial, P-selectin expression contributes to generation of immunity in cutaneous contact hypersensitivityQ39403266
Serotonin induced platelet aggregation in systemic sclerosisQ41431389
Treatment of Raynaud's phenomenon with the selective serotonin reuptake inhibitor fluoxetineQ43740421
Coagulative modifications in patients with systemic sclerosis treated with iloprost or nifedipine.Q43788021
Engagement of glycoprotein IIb/IIIa (alpha(IIb)beta3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cellsQ44179199
Raynaud's phenomenon and serotonin reuptake inhibitorsQ45093403
Supranormal von Willebrand factor multimers in sclerodermaQ45884878
The transport of high amounts of vascular endothelial growth factor by blood platelets underlines their potential contribution in systemic sclerosis angiogenesis.Q45956278
Platelet activation in patients with systemic scleroderma--pattern and significance.Q46708316
The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodelingQ47245105
Pathologic observations in systemic sclerosis (scleroderma). A study of fifty-eight autopsy cases and fifty-eight matched controlsQ49051672
Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis.Q52118613
Whole blood platelet aggregation and coagulation factors in patients with systemic sclerosis.Q52872695
Platelet sensitivity to a prostacyclin analogue in systemic sclerosis.Q53690099
A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3Q58657596
P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissuesQ58808007
Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblastsQ60537787
Increased platelet sensitivity to collagen-induced aggregation in whole blood patients with systemic sclerosisQ67951191
Plasma free and intraplatelet serotonin in patients with Raynaud's phenomenonQ68450924
Antibody-dependent cellular cytotoxicity of vascular endothelium: characterization and pathogenic associations in systemic sclerosisQ69425734
Localization of platelet antigens in human kidney diseaseQ70149169
Elevated levels of circulating platelet aggregates and beta-thromboglobulin in sclerodermaQ72664368
Mechanism of serum-mediated endothelial injury in scleroderma: identification of a granular enzyme in scleroderma skin and seraQ73162633
Endothelial and adrenergic dysfunction in Raynaud's phenomenon and sclerodermaQ73167884
Relative roles of endothelial cell damage and platelet activation in primary Raynaud's phenomenon (RP) and RP secondary to systemic sclerosisQ77305761
Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertensionQ77822568
Defective vasculogenesis in systemic sclerosisQ80457437
Scleroderma fibroblasts constitutively express the long pentraxin PTX3Q80519862
Increase in platelet non-integrin type I collagen receptor in patients with systemic sclerosisQ82087275
Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severityQ82117666
Carcinoid heart diseaseQ83399533
Modulation of the angiogenic phenotype of normal and systemic sclerosis endothelial cells by gain-loss of function of pentraxin 3 and matrix metalloproteinase 12Q84309344
Platelets mediate cytotoxic T lymphocyte-induced liver damageQ24604707
Platelets, inflammation and tissue regenerationQ28235158
Evolution of the pentraxin family: the new entry PTX4Q28278392
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic bloodQ28294906
A model of anti-angiogenesis: differential transcriptosome profiling of microvascular endothelial cells from diffuse systemic sclerosis patientsQ30478833
Interstitial lung disease (ILD) and severe ITP.Q33374583
Platelet serotonin in systemic sclerosisQ33561867
Platelets in defense against bacterial pathogensQ33604443
Innate immunity and inflammation in systemic sclerosisQ33767356
Autoimmunity and vascular involvement in systemic sclerosis (SSc).Q33876515
An integrated view of humoral innate immunity: pentraxins as a paradigmQ34020449
Platelet-mediated lymphocyte delivery to high endothelial venulesQ34384171
Platelet-derived serotonin links vascular disease and tissue fibrosisQ34973681
Beta thromboglobulin and platelet factor 4 in bronchoalveolar lavage fluid of patients with systemic sclerosisQ35555294
Vascular involvement in systemic sclerosis (scleroderma).Q35557424
Changes in causes of death in systemic sclerosis, 1972-2002Q35954516
Atherosclerosis as inflammationQ36043582
In vivo platelet production from mature megakaryocytes: does platelet release occur via proplatelets?Q36090943
Transforming growth factor-beta: a key mediator of fibrosisQ36239091
Systemic and cell type-specific gene expression patterns in scleroderma skinQ36349808
Circulating activated platelets reconstitute lymphocyte homing and immunity in L-selectin-deficient mice.Q36400175
Renal vascular histology and morphometry in systemic sclerosis. A case-control autopsy study.Q36450708
Type I interferon in systemic lupus erythematosus and other autoimmune diseasesQ36595839
Platelet contributions to the pathogenesis of systemic sclerosisQ36961456
Pentraxins, humoral innate immunity and tissue injuryQ37200012
Role of PDGF in fibrotic diseases and systemic sclerosisQ37265804
Translational mini-review series on immunology of vascular disease: mechanisms of vascular inflammation and remodelling in systemic vasculitis.Q37421806
Dangerous connections: neutrophils and the phagocytic clearance of activated plateletsQ37601206
Platelets and the immune continuumQ37857647
Contemporary management of Raynaud's phenomenon and digital ischaemic complicationsQ37925438
Platelet-leukocyte deregulated interactions foster sterile inflammation and tissue damage in immune-mediated vessel diseases.Q37975846
HMGB1: a multifunctional alarmin driving autoimmune and inflammatory diseaseQ37980335
P304page(s)160
P577publication date2012-06-18
P1433published inFrontiers in ImmunologyQ27723748
P1476titleThe role of platelets in the pathogenesis of systemic sclerosis
P478volume3

Reverse relations

cites work (P2860)
Q100559306Dermal fibroblasts have different extracellular matrix profiles induced by TGF-β, PDGF and IL-6 in a model for skin fibrosis
Q93152908Emerging Factors Implicated in Fibrotic Organ-Associated Thrombosis: The Case of Two Organs
Q49630769From Human Megakaryocytes to Platelets: Effects of Aspirin on High-Mobility Group Box 1/Receptor for Advanced Glycation End Products Axis
Q52680357From blood coagulation to innate and adaptive immunity: the role of platelets in the physiology and pathology of autoimmune disorders.
Q38427670Parietal and intravascular innate mechanisms of vascular inflammation
Q38763707Platelet-derived sphingosine-1-phosphate and inflammation: from basic mechanisms to clinical implications
Q38101678Platelets and autoimmunity.
Q92106724Platelets in Skin Autoimmune Diseases
Q41452150Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease
Q64277722The Role of Fibrinolytic Regulators in Vascular Dysfunction of Systemic Sclerosis
Q26749091Vascular Remodelling and Mesenchymal Transition in Systemic Sclerosis

Search more.