The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling

scientific article

The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1182/BLOOD-2007-05-088906
P932PMC publication ID5726330
P698PubMed publication ID18195092
P5875ResearchGate publication ID5656633

P50authorAlma ZerneckeQ21253006
Christian WeberQ37838769
P2093author name stringEsther Lutgens
Andrew C Newby
Dirk Lievens
Erwin Wijnands
Linda Beckers
Mat J A P Daemen
Randolph J Noelle
Cory L Ahonen
Jack Cleutjens
Ben J Janssen
Ulrike Benbow
Marjo M P C Donners
Johan Heemskerk
Imke Munnix
P2860cites workCD40 AND CD154 IN CELL-MEDIATED IMMUNITYQ22255634
Reduction of atherosclerosis in mice by inhibition of CD40 signallingQ24316540
The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cellsQ33711057
TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRsQ33864629
CD40 signaling and plaque instabilityQ34460843
Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotypeQ35161070
Inflammation and restenosis: implications for therapy.Q35597634
The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiationQ35850668
CD40 and its ligand in atherosclerosis.Q36812081
CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosisQ37696199
TNF receptor-associated factor 6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages.Q40474225
CD40 signaling through a newly identified tumor necrosis factor receptor-associated factor 2 (TRAF2) binding siteQ40636873
CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerizationQ42060069
Involvement of extracellular-matrix-degrading metalloproteinases in rabbit aortic smooth-muscle cell proliferationQ42092461
TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells.Q42509065
Mechanism of action of combined short-term CTLA4Ig and anti-CD40 ligand in murine systemic lupus erythematosusQ43874081
CD40-dependent activation of phosphatidylinositol 3-kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis.Q44362136
Absence of CD40 signaling is associated with an increase in intimal thickening after arterial injuryQ46113707
Low-dose FK506 blocks collar-induced atherosclerotic plaque development and stabilizes plaques in ApoE-/- mice.Q46485545
The glycoprotein VI-phospholipase Cgamma2 signaling pathway controls thrombus formation induced by collagen and tissue factor in vitro and in vivoQ46778214
CD40-mediated activation of vascular smooth muscle cell chemokine production through a Src-initiated, MAPK-dependent pathwayQ47306585
Short-term and long-term blood pressure and heart rate variability in the mouse.Q51421834
Regulation of matrix metalloproteinase expression in human vascular smooth muscle cells by T lymphocytes: a role for CD40 signaling in plaque rupture?Q52527039
Requirement for CD154 in the progression of atherosclerosis.Q52536870
Remodeling of carotid artery is associated with increased expression of matrix metalloproteinases in mouse blood flow cessation modelQ73265468
Remodeling with neointima formation in the mouse carotid artery after cessation of blood flowQ73832982
Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genesQ77658697
Flow-induced vascular remodeling in the mouse: a model for carotid intima-media thickeningQ79202824
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)4596-4604
P577publication date2008-01-14
P1433published inBloodQ885070
P1476titleThe CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling
P478volume111

Reverse relations

cites work (P2860)
Q36662416Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals
Q38972708Blockade of CD40-TRAF2,3 or CD40-TRAF6 is sufficient to inhibit pro-inflammatory responses in non-haematopoietic cells
Q51035537Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice.
Q37599837Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance
Q26752784CD40 in coronary artery disease: a matter of macrophages?
Q34005419CD40 is essential in the upregulation of TRAF proteins and NF-kappaB-dependent proinflammatory gene expression after arterial injury
Q33732210CD40 signaling to the rescue: A CD8 exhaustion perspective in chronic infectious diseases
Q35879683CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells
Q33814059CD40L and Its Receptors in Atherothrombosis-An Update
Q46991200CD40L contributes to angiotensin II-induced pro-thrombotic state, vascular inflammation, oxidative stress and endothelial dysfunction
Q46284193CD40L controls obesity-associated vascular inflammation, oxidative stress and endothelial dysfunction in mice - translational aspects for man.
Q36903682Caveolin-1 deficiency decreases atherosclerosis by hampering leukocyte influx into the arterial wall and generating a regulatory T-cell response
Q36513984Circulating inflammatory cells are associated with vein graft stenosis
Q33816471Creating a Biomarker Panel for Early Detection of Chemotherapy Related Cardiac Dysfunction in Breast Cancer Patients
Q35621648Crucial role of CD40 signaling in vascular wall cells in neointimal formation and vascular remodeling after vascular interventions
Q33656103Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile
Q41497361Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury.
Q34429450Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis
Q42713376Feeling the elephant of cardiovascular cell therapy
Q38083555Inflammation and immune system interactions in atherosclerosis
Q30849102Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation.
Q90521167MicroRNA (miRNA): A New Dimension in the Pathogenesis of Antiphospholipid Syndrome (APS)
Q43182095New frontiers for platelet CD154.
Q26865593Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation
Q47645034Platelet CD40 Mediates Leukocyte Recruitment and Neointima Formation after Arterial Denudation Injury in Atherosclerosis-Prone Mice
Q30497499Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis
Q35656802Platelet PI3Kγ Contributes to Carotid Intima-Media Thickening under Severely Reduced Flow Conditions
Q38674677Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype.
Q34708937Platelet transfusions: impact on hemostasis, thrombosis, inflammation and clinical outcomes
Q34795130Proinflammatory responses induced by CD40 in retinal endothelial and Müller cells are inhibited by blocking CD40-Traf2,3 or CD40-Traf6 signaling
Q38396097Regulation of atherosclerotic plaque inflammation
Q36000924Rosuvastatin Attenuates CD40L-Induced Downregulation of Extracellular Matrix Production in Human Aortic Smooth Muscle Cells via TRAF6-JNK-NF-κB Pathway
Q49369729Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis.
Q90723624The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease
Q37829738The CD40-CD40L system in cardiovascular disease.
Q92983665The dual role of platelet-innate immune cell interactions in thrombo-inflammation
Q33937074The platelet as an immune cell-CD40 ligand and transfusion immunomodulation
Q26996707The role of costimulatory receptors of the tumour necrosis factor receptor family in atherosclerosis
Q42203442The role of platelets in the pathogenesis of systemic sclerosis
Q33996260Tumor necrosis factor receptor associated factor 6 is not required for atherogenesis in mice and does not associate with atherosclerosis in humans
Q34369244Tumor necrosis factor receptor-associated factor 1 (TRAF1) deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wall
Q48161453Tumor necrosis factor receptor-associated factor 5 is an essential mediator of ischemic brain infarction.

Search more.