Blockade of CD40-TRAF2,3 or CD40-TRAF6 is sufficient to inhibit pro-inflammatory responses in non-haematopoietic cells

scientific article

Blockade of CD40-TRAF2,3 or CD40-TRAF6 is sufficient to inhibit pro-inflammatory responses in non-haematopoietic cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/IMM.12361
P932PMC publication ID4264907
P698PubMed publication ID25051892
P5875ResearchGate publication ID264125044

P50authorCarlos S. SubausteQ45702144
P2093author name stringJennifer A Greene
Jose-Andres C Portillo
Isaac Schwartz
Maria Cecilia Subauste
P2860cites workCD40 AND CD154 IN CELL-MEDIATED IMMUNITYQ22255634
Reduction of atherosclerosis in mice by inhibition of CD40 signallingQ24316540
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The protein kinase double-stranded RNA-dependent (PKR) enhances protection against disease cause by a non-viral pathogenQ31129671
Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profileQ33656103
The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cellsQ33711057
The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel diseaseQ33745206
CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression.Q34324146
Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154.Q34391220
CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primatesQ34433847
Mechanisms of TNF receptor-associated factor (TRAF) regulation in B lymphocytes.Q34724100
CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomesQ35009488
Inhibition of CD40 signaling limits evolution of established atherosclerosis in miceQ35160907
Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotypeQ35161070
Crucial role of CD40 signaling in vascular wall cells in neointimal formation and vascular remodeling after vascular interventionsQ35621648
CD40 ligation induces tissue factor expression in human vascular smooth muscle cellsQ35793488
Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosisQ36028683
CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive beta-chemokinesQ36065955
Specific peptides for the therapeutic targeting of oncogenesQ36353158
Antibodies to intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 prevent crescent formation in rat autoimmune glomerulonephritisQ36361382
Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretionQ36366300
CD40 and autoimmunity: the dark side of a great activator.Q37365433
Therapeutic applications of cell-penetrating peptidesQ37807348
Matrix metalloproteinase inhibition therapy for vascular diseasesQ37983293
TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cellsQ39613693
CD40 mediates retinal inflammation and neurovascular degenerationQ39909768
TNF receptor-associated factor 6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages.Q40474225
CD40 signaling through a newly identified tumor necrosis factor receptor-associated factor 2 (TRAF2) binding siteQ40636873
Cutting edge: molecular mechanisms of synergy between CD40 and the B cell antigen receptor: role for TNF receptor-associated factor 2 in receptor interaction.Q40716536
CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cellsQ40804865
Characterization of the roles of TNF receptor-associated factor 6 in CD40-mediated B lymphocyte effector functionsQ40908092
Membrane-bound CD154, but not CD40-specific antibody, mediates NF-kappaB-independent IL-6 production in B cellsQ40911442
Human dendritic cells discriminate between viable and killed Toxoplasma gondii tachyzoites: dendritic cell activation after infection with viable parasites results in CD28 and CD40 ligand signaling that controls IL-12-dependent and -independent T ceQ41749032
CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerizationQ42060069
TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells.Q42509065
Distinct contributions of different CD40 TRAF binding sites to CD154-induced dendritic cell maturation and IL-12 secretionQ44343215
Intercellular Adhesion Molecule-1–Deficient Mice Are Resistant Against Renal Injury After Induction of DiabetesQ44599812
CD40 ligand-dependent tyrosine nitration of prostacyclin synthase in vivoQ46722560
The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodelingQ47245105
CD40-mediated activation of vascular smooth muscle cell chemokine production through a Src-initiated, MAPK-dependent pathwayQ47306585
IL-4 and IL-13 augment cytokine- and CD40-induced RANTES production by human renal tubular epithelial cells in vitroQ47917213
Characterization of CD40 signaling determinants regulating nuclear factor-kappa B activation in B lymphocytes.Q52041256
Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis.Q52054451
Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor.Q52526594
Regulation of matrix metalloproteinase expression in human vascular smooth muscle cells by T lymphocytes: a role for CD40 signaling in plaque rupture?Q52527039
CD40 and tumour necrosis factor-α co-operate to up-regulate inducuble nitric oxide synthase expression in macrophages.Q53208850
Expression of CD40 and its ligand, CD40L, in intestinal lesions of Crohn's diseaseQ56906591
Immunohistologic analysis of renal CD40 and CD40L expression in lupus nephritis and other glomerulonephritidesQ67220163
Mesangial expression of intercellular adhesion molecule-1 in primary glomerulosclerosisQ67541892
A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritisQ73114791
Macrophages, smooth muscle cells, endothelial cells, and T-cells express CD40 and CD40L in fatty streaks and more advanced human atherosclerotic lesions. Colocalization with epitopes of oxidized low-density lipoprotein, scavenger receptor, and CD16Q73245727
Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cellsQ73302828
Expression of CD40 in vascular smooth muscle cells and macrophages is associated with early development of human atherosclerotic lesionsQ73344118
Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patientsQ73351358
Cell adhesion molecule expression in murine lupus-like nephritis induced by lipopolysaccharideQ73407296
Function of CD40/CD40L in peritubular capillary of renal allograft rejectionQ73667820
Deficiency of inflammatory cell adhesion molecules protects against atherosclerosis in miceQ73707721
Prevention of experimental colitis in SCID mice reconstituted with CD45RBhigh CD4+ T cells by blocking the CD40-CD154 interactionsQ73812280
Importance of monocyte chemoattractant protein-1 pathway in neointimal hyperplasia after periarterial injury in mice and monkeysQ74301083
Analysis of the oligomeric requirement for signaling by CD40 using soluble multimeric forms of its ligand, CD154Q74602347
Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient miceQ77231603
CD40 expression on graft infiltrates and parenchymal CD154 (CD40L) induction in human chronic renal allograft rejectionQ77317364
Effects of the anti-ICAM-1 monoclonal antibody on dextran sodium sulphate-induced colitis in ratsQ77483148
CD40 ligation stimulates MCP-1 and IL-8 production, TRAF6 recruitment, and MAPK activation in proximal tubule cellsQ78068575
The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switchingQ78298237
Intrinsic renal cell expression of CD40 directs Th1 effectors inducing experimental crescentic glomerulonephritisQ79187010
CD40-TRAF6 and autophagy-dependent anti-microbial activity in macrophagesQ79562635
CD40-CD40 ligand mediates the recruitment of leukocytes and platelets in the inflamed murine colonQ79835736
The TRAF6, but not the TRAF2/3, binding domain of CD40 is required for cytokine production in human lung fibroblastsQ81165279
TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alphaQ81375615
P433issue1
P304page(s)21-33
P577publication date2015-01-01
P1433published inImmunologyQ15754984
P1476titleBlockade of CD40-TRAF2,3 or CD40-TRAF6 is sufficient to inhibit pro-inflammatory responses in non-haematopoietic cells
P478volume144

Reverse relations

cites work (P2860)
Q92169746CD40 in Endothelial Cells Restricts Neural Tissue Invasion by Toxoplasma gondii
Q40594560CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy
Q35879683CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells
Q35924786Chimeric Vaccine Stimulation of Human Dendritic Cell Indoleamine 2, 3-Dioxygenase Occurs via the Non-Canonical NF-κB Pathway
Q32185814Ligation of CD40 in Human Müller Cells Induces P2X7 Receptor-Dependent Death of Retinal Endothelial Cells.
Q92618002MicroRNA-124 represents a novel diagnostic marker in human lupus nephritis and plays an inhibitory effect on the growth and inflammation of renal mesangial cells by targeting TRAF6
Q38734421MicroRNA-126 Regulates Inflammatory Cytokine Secretion in Human Gingival Fibroblasts Under High Glucose Via Targeting Tumor Necrosis Factor Receptor Associated Factor 6.
Q92959413Role of NF-κB in Platelet Function
Q39141920Systematic analysis of chromatin interactions at disease associated loci links novel candidate genes to inflammatory bowel disease
Q92538952The CD40-ATP-P2X 7 Receptor Pathway: Cell to Cell Cross-Talk to Promote Inflammation and Programmed Cell Death of Endothelial Cells
Q35810718The association of CD40 polymorphisms with CD40 serum levels and risk of systemic lupus erythematosus

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