The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease

scientific article published on 28 March 2020

The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S12265-020-09994-3
P698PubMed publication ID32222950

P2093author name stringEsther Lutgens
Lena Bosch
Laura A Bosmans
Tom T P Seijkens
Pascal J H Kusters
P2860cites workThe SNP rs1883832 in CD40 gene and risk of atherosclerosis in Chinese population: a meta-analysisQ33610203
Circulating soluble CD40 ligand mediates the interaction between neutrophils and platelets in acute coronary syndromeQ33646945
Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profileQ33656103
CD40L and Its Receptors in Atherothrombosis-An UpdateQ33814059
Reproducibility over time and effect of low-dose aspirin on soluble P-selectin and soluble CD40 ligand.Q33912722
Association between levels of circulating soluble CD40 ligand on admission and in-hospital events among acute coronary syndrome patientsQ33969881
Soluble CD40 ligand stimulates the pro-angiogenic function of peripheral blood angiogenic outgrowth cells via increased release of matrix metalloproteinase-9.Q35073314
Inhibition of CD40 signaling limits evolution of established atherosclerosis in miceQ35160907
Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotypeQ35161070
Discovery of small molecule CD40-TRAF6 inhibitorsQ35549406
Soluble CD40 ligand as a predictor of coronary artery disease and long-term clinical outcomes in stable patients undergoing coronary angiographyQ35633740
Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in miceQ35795164
Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosisQ36028683
Is there more than C-reactive protein and fibrinogen? The prognostic value of soluble CD40 ligand, interleukin-6 and oxidized low-density lipoprotein with respect to coronary and cerebral vascular disease.Q36344730
Soluble CD40 ligand induces β 3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signalingQ36350146
Systemic blood coagulation activation in acute coronary syndromesQ37116951
The immunobiology of CD154-CD40-TRAF interactions in atherosclerosis.Q37555464
Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistanceQ37599837
Soluble CD40 ligand is associated with angiographic severity of coronary artery disease in patients with acute coronary syndromeQ38220415
Antiinflammatory Therapy with Canakinumab for Atherosclerotic DiseaseQ38606033
Soluble CD40 ligand promotes macrophage foam cell formation in the etiology of atherosclerosisQ38892849
Immune checkpoint proteins: exploring their therapeutic potential to regulate atherosclerosisQ39215639
Clinical implications of elevated serum interleukin-6, soluble CD40 ligand, metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 in patients with acute ST-segment elevation myocardial infarction.Q40049103
CD40 Generation 2.5 Antisense Oligonucleotide Treatment Attenuates Doxorubicin-induced Nephropathy and Kidney Inflammation.Q40256254
CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokinesQ40761122
TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells.Q42509065
Crosstalk between T cells and bronchial fibroblasts obtained from asthmatic subjects involves CD40L/alpha 5 beta 1 interactionQ43062632
Exploring immune checkpoints as potential therapeutic targets in atherosclerosisQ47224948
The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodelingQ47245105
Silencing of CD40 in vivo reduces progression of experimental atherogenesis through an NF-κB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosisQ47993155
A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defenseQ48095930
A comparative study of biomarkers for risk prediction in acute coronary syndrome-Results of the SIESTA (Systemic Inflammation Evaluation in non-ST-elevation Acute coronary syndrome) study.Q48133497
Diurnal variation of soluble CD40 ligand in patients with acute coronary syndrome. Soluble CD40 ligand and diurnal variationQ48431300
Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis.Q49369729
Distinct CD40L receptors mediate inflammasome activation and secretion of IL-1β and MCP-1 in cultured human retinal pigment epithelial cells.Q49895966
Relation of C4b-binding protein to athero-sclerosis of the descending thoracic aorta.Q51583432
CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1.Q51798890
Requirement for CD154 in the progression of atherosclerosis.Q52536870
Mechanism and functional impact of CD40 ligand-induced von Willebrand factor release from endothelial cells.Q52973871
Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes.Q53192004
The CD40 gene polymorphism rs1883832 is associated with risk of acute coronary syndrome in a Chinese case-control study.Q54401140
Multiple effects of CD40–CD40L axis in immunity against infection and cancer.Q55518078
Measurement of soluble P-selectin and soluble CD40 ligand in serum and plasmaQ57313116
Soluble CD40 Ligand in Acute Coronary SyndromesQ58816350
Complement regulation in human atherosclerotic coronary lesionsQ59244329
C4b-Binding Protein (C4BP) Activates B Cells through the CD40 ReceptorQ60250685
CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanismQ63354517
Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primatesQ63560435
Targeting Residual Inflammatory Risk: A Shifting Paradigm for Atherosclerotic DiseaseQ64087475
Role of CD40 and ADAMTS13 in von Willebrand factor-mediated endothelial cell-platelet-monocyte interaction.Q64894351
Biological function of CD40 on human endothelial cells: costimulation with CD40 ligand and interleukin-4 selectively induces expression of vascular cell adhesion molecule-1 and P-selectin resulting in preferential adhesion of lymphocytesQ74121901
Lack of association between soluble CD40L and risk in a large cohort of patients with acute coronary syndrome in OPUS TIMI-16Q81400150
HSP 70 and atherosclerosis--protector or activator?Q83390162
The role of CD154 in haematopoietic developmentQ84699936
Soluble CD40 ligand impairs the anti-platelet function of peripheral blood angiogenic outgrowth cells via increased production of reactive oxygen speciesQ86174278
Predictive value of elevated soluble CD40 ligand in patients undergoing primary angioplasty for ST-segment elevation myocardial infarctionQ87367180
Influence of circadian blood pressure alterations on serum SCUBE-1 and soluble CD40 ligand levels in patients with essential hypertensionQ90088047
Association of soluble CD40L with short-term and long-term cardiovascular and all-cause mortality: The Ludwigshafen Risk and Cardiovascular Health (LURIC) studyQ90314267
Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral immunity and beyondQ90539200
Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failureQ90908612
Cost-effectiveness of Canakinumab for Prevention of Recurrent Cardiovascular EventsQ91071188
Efficacy and Safety of Low-Dose Colchicine after Myocardial InfarctionQ91304576
Residual inflammatory risk in coronary heart disease: incidence of elevated high-sensitive CRP in a real-world cohortQ92037032
Low-Dose Methotrexate for the Prevention of Atherosclerotic EventsQ92980641
P921main subjectcardiovascular diseaseQ389735
P577publication date2020-03-28
P1433published inJournal of Cardiovascular Translational ResearchQ6294906
P1476titleThe CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease