CD40 signaling to the rescue: A CD8 exhaustion perspective in chronic infectious diseases

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CD40 signaling to the rescue: A CD8 exhaustion perspective in chronic infectious diseases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1615/CRITREVIMMUNOL.2013007444
P932PMC publication ID4051158
P698PubMed publication ID23971530

P2093author name stringImtiaz A Khan
Rajarshi Bhadra
Dustin A Cobb
P2860cites workCutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiationQ79370168
RANK and RANKL expression as markers of dendritic cell-T cell interactions in paired samples of rheumatoid synovium and lymph nodesQ80955797
Dendritic cells produce TSLP that limits the differentiation of Th17 cells, fosters Treg development, and protects against colitisQ83212615
The CD40 agonist antibody CP-870,893 enhances dendritic cell and B-cell activity and promotes anti-tumor efficacy in SCID-hu miceQ83822496
CD40 expression levels modulate regulatory T cells in Leishmania donovani infectionQ84357899
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineagesQ24642180
Viral immune evasion due to persistence of activated T cells without effector functionQ24646943
Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin productionQ24676570
CD40-CD40 ligandQ28143324
A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cellsQ28187669
Differential regulation of cell survival by CD40Q28201459
Restoring function in exhausted CD8 T cells during chronic viral infectionQ28289222
TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40Q28610812
Toll-like receptors and their crosstalk with other innate receptors in infection and immunityQ29547722
Origin and physiological roles of inflammationQ29614298
Follicular helper CD4 T cells (TFH)Q29615063
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cellsQ29616205
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania majorQ29619125
T cell exhaustionQ29620463
T-cell quality in memory and protection: implications for vaccine designQ30014840
The role of CTLA-4 in the regulation of T cell immune responses.Q33547785
Enhancing CD8 T-cell memory by modulating fatty acid metabolismQ33577204
Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancerQ33584851
The CD8 T-cell road to immunotherapy of toxoplasmosisQ33732215
CD40 ligand-mediated interactions are involved in the generation of memory CD8(+) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infectionQ33783902
Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infectionQ33930475
Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM.Q33947934
The CD40/CD40 ligand interaction is required for resistance to toxoplasmic encephalitis.Q34003535
Stimulation of dendritic cells via CD40 enhances immune responses to Mycobacterium tuberculosis infection.Q34006917
Regulatory T cells and Foxp3Q34177949
Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infectionQ34239730
Interleukin-21: a multifunctional regulator of immunity to infectionsQ34388287
Redefining chronic toxoplasmosis--a T cell exhaustion perspectiveQ34446628
Effector and memory CD8+ T cell fate coupled by T-bet and eomesoderminQ34465675
Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cellsQ34481433
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infectionQ34570624
Fas ligation induces apoptosis of CD40-activated human B lymphocytesQ39018355
IL-21 is required to control chronic viral infectionQ39328817
TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cellsQ39613693
Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody.Q40456758
Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implicationsQ40566183
Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.Q40695934
CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1.Q40745472
The immunological synapse and CD28-CD80 interactions.Q40767962
Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferationQ40957673
CD40 expression by human bronchial epithelial cellsQ40958158
Association between IL-6 and CD40 signaling. IL-6 induces phosphorylation of CD40 receptorsQ41724340
Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.Q41825142
Kinetics and phenotype of vaccine-induced CD8+ T-cell responses to Toxoplasma gondiiQ41850308
A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection.Q42055809
CD40/CD40L interaction regulates CD4+CD25+ T reg homeostasis through dendritic cell-produced IL-2.Q42473719
CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signalQ42834238
CD40-dependent activation of phosphatidylinositol 3-kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis.Q44362136
Prevention of CD40-triggered dendritic cell maturation and induction of T-cell hyporeactivity by targeting of Janus kinase 3.Q44606335
Agonistic anti-CD40 antibody profoundly suppresses the immune response to infection with lymphocytic choriomeningitis virusQ45408162
Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infectionQ45420662
IL-21R on T cells is critical for sustained functionality and control of chronic viral infectionQ46697142
The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodelingQ47245105
T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactionsQ47982736
Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cellsQ47992054
Editorial: (CD)40 winks to prevent CD8+ T cell lethargy.Q50952518
Synergistic CD40 signaling on APCs and CD8 T cells drives efficient CD8 response and memory differentiation.Q50973379
Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation.Q51982384
Rewiring of CD40 is necessary for delivery of rescue signals to B cells in germinal centres and subsequent entry into the memory pool.Q52020338
Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells.Q54378086
Activation of the Ras signaling pathway by the CD40 receptorQ71555540
Regulation of CD40L expression on natural killer cells by interleukin-12 and interferon gamma: its role in the elicitation of an effective antitumor immune responseQ73326013
CD40 triggered human monocyte-derived dendritic cells convert to tolerogenic dendritic cells when JAK3 activity is inhibitedQ74604829
A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memoryQ74813297
Dendritic cells require maturation via CD40 to generate protective antitumor immunityQ77186016
Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set pointsQ34573008
Molecular mechanisms of TNFR-associated factor 6 (TRAF6) utilization by the oncogenic viral mimic of CD40, latent membrane protein 1 (LMP1).Q34696221
Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survivalQ34702800
Viral persistence redirects CD4 T cell differentiation toward T follicular helper cellsQ34973705
CD8 T cell responses to infectious pathogens.Q34987912
Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1-PDL-1 blockadeQ35021925
Foxp3+ follicular regulatory T cells control the germinal center response.Q35239023
Cutting edge: CD40-CD40 ligand pathway plays a critical CD8-intrinsic and -extrinsic role during rescue of exhausted CD8 T cellsQ35403309
Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral loadQ35621976
Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection.Q35641516
Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockadeQ35650992
Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection.Q35670114
CD40/CD154 interactions at the interface of tolerance and immunityQ35698455
CD40 activation: potential for specific immunotherapy in B-CLL.Q35777555
Helping the CD8(+) T-cell responseQ35852274
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATFQ35889683
The role of TRAF6 in signal transduction and the immune responseQ35957616
Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infectionQ36073682
The origins, function, and regulation of T follicular helper cellsQ36118326
PD-1-mediated attrition of polyfunctional memory CD8+ T cells in chronic toxoplasma infectionQ36154143
Human basophils as effectors and immunomodulators of allergic inflammation and innate immunityQ36227370
Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockadeQ36227971
Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells.Q36229658
CD40-deficient, influenza-specific CD8 memory T cells develop and function normally in a CD40-sufficient environmentQ36371544
Natural regulatory T cells and persistent viral infectionQ36423940
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infectionQ36637922
TRAF proteins in CD40 signalingQ36882612
Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockadeQ36937145
The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood.Q37210857
Recall responses by helpless memory CD8+ T cells are restricted by the up-regulation of PD-1Q37270327
The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses.Q37287296
Molecular mechanism and function of CD40/CD40L engagement in the immune system.Q37474929
T cell exhaustion in protozoan diseaseQ38029470
P433issue4
P304page(s)361-378
P577publication date2013-01-01
P1433published inCritical Reviews in ImmunologyQ5186668
P1476titleCD40 signaling to the rescue: A CD8 exhaustion perspective in chronic infectious diseases
P478volume33

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cites work (P2860)
Q64074229CD8 T Cells Cry for CD4 Help
Q38611895Immunological landscape and immunotherapy of hepatocellular carcinoma
Q36302336The human immune response to Toxoplasma: Autophagy versus cell death.

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