Prevention of CD40-triggered dendritic cell maturation and induction of T-cell hyporeactivity by targeting of Janus kinase 3.

scientific article published in November 2003

Prevention of CD40-triggered dendritic cell maturation and induction of T-cell hyporeactivity by targeting of Janus kinase 3. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.1600-6143.2003.00225.X
P698PubMed publication ID14525593
P5875ResearchGate publication ID9065778

P50authorMaximilian ZeydaQ42753156
P2093author name stringGeorg A Böhmig
Walter H Hörl
Gerhard J Zlabinger
Marcus D Säemann
Thomas Baumruker
Ernst Kriehuber
Peter Kelemen
Christos Diakos
P2860cites workCD40 AND CD154 IN CELL-MEDIATED IMMUNITYQ22255634
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activationQ24677534
Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial productsQ24678867
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alphaQ28251443
Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycinQ28568866
Immunobiology of dendritic cellsQ29547465
Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allograftsQ32133064
Cytokine receptor signaling pathwaysQ33916985
Dendritic cells and prospects for transplantation toleranceQ34046816
Of genes and phenotypes: the immunological and molecular spectrum of combined immune deficiency. Defects of the gamma(c)-JAK3 signaling pathway as a modelQ34159335
Dendritic cells in transplantation--friend or foe?Q34241103
Designer dendritic cells for tolerance induction: guided not misguided missilesQ34319943
What's in the pipeline? New immunosuppressive drugs in transplantationQ35025829
Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoidsQ35209017
Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejectionQ35939463
Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.Q36417432
Jaks and Stats in signaling by the cytokine receptor superfamilyQ40506662
The role of Jak3 in lymphoid development, activation, and signalingQ41587141
Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD miceQ44410698
JAK/STAT signaling by cytokine receptorsQ46606420
Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation ToleranceQ61651670
CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathwayQ73509859
Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survivalQ74015557
Janus kinase 3 inhibitor WHI-P131/JANEX-1 prevents graft-versus-host disease but spares the graft-versus-leukemia function of the bone marrow allografts in a murine bone marrow transplantation modelQ74097996
Targeting Janus kinase 3 to attenuate the severity of acute graft-versus-host disease across the major histocompatibility barrier in miceQ74420476
CD40 triggered human monocyte-derived dendritic cells convert to tolerogenic dendritic cells when JAK3 activity is inhibitedQ74604829
Operational tolerance induced by pretreatment with donor dendritic cells under blockade of CD40 pathwayQ77167696
Targeting Jak3 for immune suppression and allograft acceptanceQ77369733
Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primatesQ77890140
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectdendritic cellQ506253
P304page(s)1341-1349
P577publication date2003-11-01
P1433published inAmerican Journal of TransplantationQ4744273
P1476titlePrevention of CD40-triggered dendritic cell maturation and induction of T-cell hyporeactivity by targeting of Janus kinase 3.
P478volume3

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cites work (P2860)
Q35825869A new modality for immunosuppression: targeting the JAK/STAT pathway
Q35994891Activation of the Jak3 pathway and myeloid differentiation
Q37386167Agonistic antibody to CD40 boosts the antitumor activity of adoptively transferred T cells in vivo
Q64913188B Cell-Based Cancer Immunotherapy.
Q33732210CD40 signaling to the rescue: A CD8 exhaustion perspective in chronic infectious diseases
Q36339318CD40/CD154 blockade inhibits dendritic cell expression of inflammatory cytokines but not costimulatory molecules
Q35953521Characterisation of a dendritic cell subset in synovial tissue which strongly expresses Jak/STAT transcription factors from patients with rheumatoid arthritis
Q37438637Curcumin Suppressed Activation of Dendritic Cells via JAK/STAT/SOCS Signal in Mice with Experimental Colitis
Q35636761Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis
Q28586242Jak3 negatively regulates dendritic-cell cytokine production and survival
Q35887829Janus kinase-3 (JAK3) inhibition: a novel immunosuppressive option for allogeneic transplantation
Q35031161Janus kinase-3 dependent inflammatory responses in allergic asthma
Q37474929Molecular mechanism and function of CD40/CD40L engagement in the immune system.
Q39738927Osteopontin affects macrophage polarization promoting endocytic but not inflammatory properties.
Q28315036Role of Janus Kinase 3 in Predisposition to Obesity-associated Metabolic Syndrome
Q36881600Targeting mast cells in endometriosis with janus kinase 3 inhibitor, JANEX-1.

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