Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): a randomised, double-blind, placebo-controlled phase 3 trial

scientific article published on 4 June 2014

Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): a randomised, double-blind, placebo-controlled phase 3 trial is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0140-6736(14)60538-9
P698PubMed publication ID24907224

P50authorSivi Ouwerkerk-MahadevanQ47158918
Maria Beumont-MauvielQ47158921
Fred PoordadQ47412568
Ewa JanczewskaQ59830669
Patrick MarcellinQ89798262
Maria ButiQ91265862
P2093author name stringYves Horsmans
Oliver Lenz
Maria Beumont-Mauviel
Monika Peeters
Sivi Ouwerkerk-Mahadevan
Michael Manns
Jane Scott
Ronald Kalmeijer
Federico Villamil
Rekha Sinha
Guy De La Rosa
Evaldo Stanislau Affonso de Araujo
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Telaprevir for previously treated chronic HCV infectionQ34109057
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In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435.Q39736457
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Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trialQ42211649
Simeprevir increases rate of sustained virologic response among treatment-experienced patients with HCV genotype-1 infection: a phase IIb trialQ42242013
Antiviral activity of TMC435 monotherapy in patients infected with HCV genotypes 2-6: TMC435-C202, a phase IIa, open-label studyQ42977630
Telaprevir and peginterferon with or without ribavirin for chronic HCV infectionQ42987218
Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infectionQ42989510
Rapid HCV-RNA decline with once daily TMC435: a phase I study in healthy volunteers and hepatitis C patientsQ42992022
Influence of the HCV subtype on the virological response to pegylated interferon and ribavirin therapyQ42992084
P433issue9941
P407language of work or nameEnglishQ1860
P921main subjecthepatitis CQ154869
placeboQ269829
ribavirinQ421862
Hepatitis C virusQ708693
interferon alfaQ6046441
pegylated interferonQ7160835
simeprevirQ7517689
chronic hepatitis CQ55779873
chronic hepatitisQ62019625
phase III clinical trialQ42824827
P304page(s)414-426
P577publication date2014-06-04
P1433published inThe LancetQ939416
P1476titleSimeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): a randomised, double-blind, placebo-controlled phase 3 trial
P478volume384

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