Potent neurotoxic fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs as potential probes in models of Parkinson disease

scientific article published on April 1988

Potent neurotoxic fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs as potential probes in models of Parkinson disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1471-4159.1988.TB10610.X
P698PubMed publication ID3258018

P2093author name stringSayre LM
Harik SI
Arora PK
Riachi NJ
P2860cites workCorrelation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity with blood-brain barrier monoamine oxidase activityQ34625772
A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridineQ37343442
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicityQ37683630
Monoamine neurotransmitters in diffuse reversible forebrain ischemia and early recirculation: increased dopaminergic activityQ48330557
Distribution of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in experimental animals studied by postiron emission tomography and whole body autoradiographyQ48386571
Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitorsQ48614146
Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidaseQ48681443
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectParkinson's diseaseQ11085
neurotoxicityQ3338704
P304page(s)1319-1321
P577publication date1988-04-01
P1433published inJournal of NeurochemistryQ6295643
P1476titlePotent neurotoxic fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs as potential probes in models of Parkinson disease
P478volume50

Reverse relations

cites work (P2860)
Q44416117An Improved Preparation of 3,5-Bis(trifluoromethyl)acetophenone and Safety Considerations in the Preparation of 3,5-Bis(trifluoromethyl)phenyl Grignard Reagent
Q68329869Molecular determinants in the bioactivation of the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Q43679571Neurotoxin mechanisms and processes relevant to Parkinson's disease: an update
Q37567182Orally delivered water soluble Coenzyme Q10 (Ubisol-Q10) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson's disease
Q36916051Pyridine Derivatives: Structure-Activity Relationships Causing Parkinsonism-Like Symptoms
Q30955390Selective neurotoxins, chemical tools to probe the mind: the first thirty years and beyond
Q38005634The MPTP story: MAO activates tetrahydropyridine derivatives to toxins causing parkinsonism