Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier

scientific article published on 24 April 2010

Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BMCL.2010.04.086
P932PMC publication ID3725995
P698PubMed publication ID20466543

P2093author name stringPeter A Crooks
Quentin R Smith
Jun Oki
David R Worthen
Jyothi Matharu
P2860cites workTransport of glutamate and other amino acids at the blood-brain barrierQ28374449
Affinity of antineoplastic amino acid drugs for the large neutral amino acid transporter of the blood-brain barrierQ34004944
Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigmQ34632917
Chemotherapy delivery issues in central nervous system malignancy: a reality check.Q36835363
Topoisomerase I inhibitors for the treatment of brain tumorsQ37159504
Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2.Q37227297
Selective cytotoxicity of a system L specific amino acid nitrogen mustardQ42223942
Synthesis and analgesic properties of two leucine-enkephalin analogues containing a conformationally restrained N-terminal tyrosine residueQ42259377
Rapid high-affinity transport of a chemotherapeutic amino acid across the blood-brain barrierQ48492787
An in situ brain perfusion technique to study cerebrovascular transport in the rat.Q48627674
Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injectionQ51116341
Leucine enkephalin analogues containing a conformationally restrained N-terminal amino acid residue.Q53912043
Differential DNA cross-linking and cytotoxicity in PHA-stimulated human lymphocytes exposed to melphalan, m-L-sarcolysin and peptichemioQ69397239
Facilitated transport of melphalan at the rat blood-brain barrier by the large neutral amino acid carrier systemQ69745648
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectblood–brain barrierQ221694
P1104number of pages4
P304page(s)3688-3691
P577publication date2010-04-24
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titleRegiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier
P478volume20