Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm

scientific article

Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1200/JCO.2006.10.0677
P698PubMed publication ID17538177

P2093author name stringRobert L Fine
Elizabeth R Gerstner
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectblood–brain barrierQ221694
brain tumorQ233309
chemotherapyQ974135
P304page(s)2306-2312
P577publication date2007-06-01
P1433published inJournal of Clinical OncologyQ400292
P1476titleIncreased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm
P478volume25

Reverse relations

cites work (P2860)
Q41820394Activity of pemetrexed and high-dose gefitinib in an EGFR-mutated lung adenocarcinoma with brain and leptomeningeal metastasis after response to gefitinib
Q28710150Alterations of chemotherapeutic pharmacokinetic profiles by drug-drug interactions
Q34633703Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy
Q48632565Attributes of brain metastases from breast and lung cancer
Q57176317Barriers to Effective Drug Treatment for Brain Metastases: A Multifactorial Problem in the Delivery of Precision Medicine
Q36284456Bevacizumab in the treatment of five patients with breast cancer and brain metastases: Japan Breast Cancer Research Network-07 trial
Q48444978Bioluminescence and MR Imaging of the Safety and Efficacy of Vascular Disruption in Gliomas
Q38259683Bone marrow-derived stem cell therapy for metastatic brain cancers
Q28078998Breast cancer brain metastases: biology and new clinical perspectives
Q35586669Breast cancer with brain metastases: clinicopathologic features, survival, and paired biomarker analysis
Q37573461Cancer and the metastatic substrate
Q35034764Central nervous system failure in melanoma patients: results of a randomised, multicentre phase 3 study of temozolomide- and dacarbazine- based regimens
Q39331752Challenges in the delivery of therapies to melanoma brain metastases
Q38792519Challenges in the treatment of hormone receptor-positive, HER2-negative metastatic breast cancer with brain metastases
Q91410839Challenges to curing primary brain tumours
Q36721489Characterization of passive permeability at the blood-tumor barrier in five preclinical models of brain metastases of breast cancer
Q24194415Chemotherapy for newly diagnosed inoperable brain metastases from non-small cell lung cancer
Q94401116Chemotherapy for newly diagnosed inoperable brain metastases from non‐small cell lung cancer
Q38096437Chemotherapy in the management of brain metastases: the emerging role of fotemustine for patients with melanoma and NSCLC.
Q46099780Chemotherapy-related posterior reversible leukoencephalopathy syndrome
Q38265614Chimeric adeno-associated virus and bacteriophage: a potential targeted gene therapy vector for malignant glioma
Q35146078Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy.
Q44156403Convection-enhanced delivery of topotecan into diffuse intrinsic brainstem tumors in children
Q38691508Crossing the barrier: treatment of brain tumors using nanochain particles
Q36186315DNA topoisomerase I drugs and radiotherapy for lung cancer
Q27851801Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.
Q33794890Determinants of survival in patients with brain metastases from cutaneous melanoma
Q38759920Developmental therapeutics for patients with breast cancer and central nervous system metastasis: current landscape and future perspectives.
Q47573654Drug delivery to melanoma brain metastases: Can current challenges lead to new opportunities?
Q37362486Drug interactions at the blood-brain barrier: fact or fantasy?
Q34581741Early gastric cancer with suspected brain metastasis arising eight years after curative resection: a case report
Q39637384Effect of chemotherapy on survival after whole brain radiation therapy for brain metastases: a single-center retrospective analysis
Q37091154Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells
Q92874415Effects of Radiation Therapy on Neural Stem Cells
Q33620317Efficacy and safety of ipilimumab in patients with advanced melanoma and brain metastases
Q38616077Efficacy of XELOX plus Bevacizumab in Brain Metastasis from Rectal Cancer
Q89408783Efficacy of the MDM2 Inhibitor SAR405838 in Glioblastoma Is Limited by Poor Distribution Across the Blood-Brain Barrier
Q46944135Eligibility of patients with brain metastases for phase I trials: time for a rethink?
Q38953017Embracing rejection: Immunologic trends in brain metastasis
Q88497994Emerging Gene Fusion Drivers in Primary and Metastatic Central Nervous System Malignancies: A Review of Available Evidence for Systemic Targeted Therapies
Q35075446Emerging strategies for treating brain metastases from breast cancer
Q37157248Engineered knottin peptide enables noninvasive optical imaging of intracranial medulloblastoma
Q37968607Epilepsy in patients with a brain tumour: focal epilepsy requires focused treatment
Q34673086Fluorescent affibody peptide penetration in glioma margin is superior to full antibody
Q34565460Fluoxetine modulates breast cancer metastasis to the brain in a murine model
Q36851190Gliadel for brain metastasis.
Q34393640Heterogeneous Blood–Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer
Q28540667In silico prediction of inhibition of promiscuous breast cancer resistance protein (BCRP/ABCG2)
Q37747100Inhibition of VEGF and Angiopoietin-2 to Reduce Brain Metastases of Breast Cancer Burden
Q64057768Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis
Q59329795Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma
Q42593884Intercellular transfer of small RNAs from astrocytes to lung tumor cells induces resistance to chemotherapy
Q44647936Intrathecal application of donor lymphocytes in leukemic meningeosis after allogeneic stem cell transplantation
Q36371783Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast cancer.
Q34016491Lapatinib for the treatment of breast cancer in the People's Republic of China
Q46423087Long-lasting successful cerebral response with sorafenib in advanced renal cell carcinoma
Q52087016Lung cancer-associated brain metastasis: Molecular mechanisms and therapeutic options.
Q33989239MRI-based characterization of vascular disruption by 5,6-dimethylxanthenone-acetic acid in gliomas
Q57181658Magnetic targeting of paclitaxel-loaded poly(lactic--glycolic acid)-based nanoparticles for the treatment of glioblastoma
Q37812446Medical Management of Brain Metastases
Q38766796Melanoma Brain Metastases: Current Areas of Investigation and Future Directions
Q38807942Melanoma central nervous system metastases: current approaches, challenges, and opportunities
Q37738771Modern multidisciplinary management of brain metastases
Q37080236Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy
Q37819809Monoclonal antibodies in neuro-oncology: Getting past the blood-brain barrier
Q37579928Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases
Q37303869New challenges and opportunities in the management of brain metastases in patients with ErbB2-positive metastatic breast cancer
Q35734471Novel treatment strategies for brain tumors and metastases
Q47944360Obstacles to Brain Tumor Therapy: Key ABC Transporters
Q38067340Optimal management of brain metastases from breast cancer. Issues and considerations
Q36888327Pazopanib inhibits the activation of PDGFRβ-expressing astrocytes in the brain metastatic microenvironment of breast cancer cells
Q39690634Peptide-based leptin receptor antagonists for cancer treatment and appetite regulation
Q34708283Pharmacokinetics and efficacy of PEGylated liposomal doxorubicin in an intracranial model of breast cancer.
Q98476068Physiologically Based Pharmacokinetic Modeling of Central Nervous System Pharmacokinetics of CDK4/6 Inhibitors to Guide Selection of Drug and Dosing Regimen for Brain Cancer Treatment
Q35627248Prolonged survival of a patient with metastatic leptomeningeal melanoma treated with BRAF inhibition-based therapy: a case report
Q48401767Protracted low dose of oral vinorelbine and temozolomide with whole-brain radiotherapy in the treatment for breast cancer patients with brain metastases
Q45046519Quantitative Fluorescence Microscopy Measures Vascular Pore Size in Primary and Metastatic Brain Tumors
Q48105538Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood-Brain Barrier in Glioblastoma Patients Using an IVIVE-PBPK Modeling Approach
Q54962187Recent advances in the biology and treatment of brain metastases of non-small cell lung cancer: summary of a multidisciplinary roundtable discussion.
Q42214301Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier
Q35071355Regression of brain metastases from breast cancer with eribulin: a case report
Q37084982Regression of recurrent malignant gliomas with convection-enhanced delivery of topotecan
Q38101607Revisiting the role of systemic therapies in patients with metastatic melanoma to the CNS.
Q38010057Risk of intracranial hemorrhage with anticoagulation therapy in melanoma patients with brain metastases
Q36898626Safety and efficacy of carmustine (BCNU) wafers for metastatic brain tumors.
Q60045957Safety evaluation of frequent application of microbubble-enhanced focused ultrasound blood-brain-barrier opening
Q30429246Short-time focused ultrasound hyperthermia enhances liposomal doxorubicin delivery and antitumor efficacy for brain metastasis of breast cancer
Q61809370Significant response of low-dose apatinib monotherapy in brain metastases of triple-negative breast cancer: A case report
Q33507517Small vessel ischemic disease of the brain and brain metastases in lung cancer patients
Q80940181Survival in patients with brain metastases from breast cancer: the importance of HER-2 status
Q48234725Survival patterns following brain metastases for patients with melanoma in the MAP-kinase inhibitor era.
Q41428337Systemic therapy for echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase non-small cell lung cancer brain metastases.
Q39652258Systemic treatment of brain metastases in HER2-positive breast cancer: current status and future directions
Q39675468TP53 regulates human AlkB homologue 2 expression in glioma resistance to Photofrin-mediated photodynamic therapy.
Q38715328Targeted Therapies for the Treatment of Brain Metastases in Solid Tumors
Q37231972Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases
Q47247953The biology and therapeutic management of melanoma brain metastases
Q38564085The future of targeted therapies for brain metastases
Q38259586The management of brain metastases in non-small cell lung cancer
Q38614374The role of astrocytes in the progression of brain cancer: complicating the picture of the tumor microenvironment.
Q33599111The role of chemotherapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline
Q37586262The role of chemotherapy in the treatment of patients with brain metastases from solid tumors
Q47735641The role of nivolumab in melanoma
Q58023833Therapie von Hirnmetastasen und Meningeosis neoplastica
Q37809862Therapy and prophylaxis of brain metastases
Q37967507Treatment of brain metastases: chemotherapy
Q44534087Vemurafenib and radiation therapy in melanoma brain metastases
Q50942238Whole-brain radiation fails to boost intracerebral gefitinib concentration in patients with brain metastatic non-small cell lung cancer: a self-controlled, pilot study.
Q84010105[Treatment of advanced metastatic melanoma]

Search more.