Systemic treatment of brain metastases in HER2-positive breast cancer: current status and future directions

scientific article published on February 2012

Systemic treatment of brain metastases in HER2-positive breast cancer: current status and future directions is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2217/FON.11.149
P698PubMed publication ID22335578
P5875ResearchGate publication ID221833544

P2093author name stringHatem A Azim
Hamdy A Azim
P2860cites workUptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancerQ24621947
Lapatinib plus capecitabine for HER2-positive advanced breast cancerQ27851403
Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancerQ27851549
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastomaQ27860910
Phosphodiesterase type 5 inhibitors increase Herceptin transport and treatment efficacy in mouse metastatic brain tumor modelsQ28473716
The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporterQ28477938
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancerQ29616112
Targeting multidrug resistance in cancerQ29616803
Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brainQ33283845
Dose-dense temozolomide regimen for the treatment of brain metastases from melanoma, breast cancer, or lung cancer not amenable to surgery or radiosurgery: a multicenter phase II study.Q33386298
The role of chemotherapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guidelineQ33599111
Treatment of HER2-positive metastatic breast cancer with lapatinib and capecitabine in the lapatinib expanded access programme, including efficacy in brain metastases--the UK experience.Q33747400
Multifactorial central nervous system recurrence susceptibility in patients with HER2-positive breast cancer: epidemiological and clinical data from a population-based cancer registry study.Q33878643
Incidence, pattern and timing of brain metastases among patients with advanced breast cancer treated with trastuzumabQ48612753
Randomized phase II study of lapatinib plus capecitabine or lapatinib plus topotecan for patients with HER2-positive breast cancer brain metastasesQ49123747
2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial.Q53243856
Central nervous system metastases in patients with HER2-positive metastatic breast cancer: incidence, treatment, and survival in patients from registHER.Q54573427
Clinical outcome of patients with brain metastases from HER2-positive breast cancer treated with lapatinib and capecitabine.Q54654985
Incidence Proportions of Brain Metastases in Patients Diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance SystemQ57407206
Trastuzumab in the adjuvant treatment of HER2-positive early breast cancer patients: a meta-analysis of published randomized controlled trialsQ33939795
Brain metastases from breast cancer: prognostic significance of HER-2 overexpression, effect of trastuzumab and cause of deathQ34022312
Vardenafil: structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5).Q34341349
Heterogeneous Blood–Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast CancerQ34393640
Breast cancer metastasis to the central nervous systemQ34455205
The blood-brain barrier and cancer: transporters, treatment, and Trojan horsesQ34577796
Prognostic factors of survival in the trastuzumab era among women with breast cancer and brain metastases who receive whole brain radiotherapy: a single-institution reviewQ34583604
Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigmQ34632917
Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2.Q34779629
Regulation and function of cyclic nucleotidesQ35256720
Breast cancer resistance protein and P-glycoprotein in brain cancer: two gatekeepers team upQ35720625
Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancerQ35914677
Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and developmentQ36874299
Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brainQ36954809
A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analysesQ37054957
PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor modelQ37076589
Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2Q37119716
LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studiesQ37216064
Targeting Her-2/neu in breast cancer: as easy as this!Q37245691
Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brainQ37278215
International guidelines for management of metastatic breast cancer: combination vs sequential single-agent chemotherapyQ37329165
Human epidermal growth factor receptor 2-positive breast cancer and central nervous system metastasesQ37601140
Monoclonal antibodies in neuro-oncology: Getting past the blood-brain barrierQ37819809
Metastatic behavior of breast cancer subtypesQ38416421
Role of efflux pump activity in lapatinib/caelyx combination in breast cancer cell linesQ39799826
The risk of central nervous system metastases after trastuzumab therapy in patients with breast carcinomaQ40490061
Disruption of the blood brain barrier by brain metastases of triple-negative and basal-type breast cancer but not HER2/neu-positive breast cancerQ42463524
Identifying breast cancer patients at risk for Central Nervous System (CNS) metastases in trials of the International Breast Cancer Study Group (IBCSG).Q43846885
Trastuzumab treatment beyond brain progression in HER2-positive metastatic breast cancerQ44176007
Preliminary results of whole brain radiotherapy with concurrent trastuzumab for treatment of brain metastases in breast cancer patientsQ44689634
A randomized, placebo-controlled, double-blind phase 2 study of docetaxel compared to docetaxel plus zosuquidar (LY335979) in women with metastatic or locally recurrent breast cancer who have received one prior chemotherapy regimenQ45125373
Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancerQ46116627
Phase 2 trial of temozolomide using protracted low-dose and whole-brain radiotherapy for nonsmall cell lung cancer and breast cancer patients with brain metastases.Q46362575
Characteristics of patients with brain metastases receiving trastuzumab for HER2 overexpressing metastatic breast cancerQ46606673
Capecitabine therapy of central nervous system metastases from breast cancerQ48115520
Trastuzumab prolongs overall survival in patients with brain metastases from Her2 positive breast cancerQ48142933
Increased rate of brain metastasis with trastuzumab therapy not associated with impaired survivalQ48253215
CXCR4 expression in early breast cancer and risk of distant recurrenceQ48398507
Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancerQ48575675
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectbrain metastasisQ1620196
P304page(s)135-144
P577publication date2012-02-01
P1433published inFuture OncologyQ2781597
P1476titleSystemic treatment of brain metastases in HER2-positive breast cancer: current status and future directions
P478volume8

Reverse relations

cites work (P2860)
Q59339787A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases
Q36288549Analysis of gene expression of secreted factors associated with breast cancer metastases in breast cancer subtypes
Q89257523Antibody pharmacokinetics in rat brain determined using microdialysis
Q47606935Delivery of Biologics Across the Blood-Brain Barrier with Molecular Trojan Horse Technology
Q38846435Effect of Oncoxin Oral Solution in HER2-Overexpressing Breast Cancer
Q37136423Effect of adjuvant trastuzumab treatment in conventional clinical setting: an observational retrospective multicenter Italian study
Q48268775HER2 blockade in metastatic collecting duct carcinoma (CDC) of the kidney: a case report
Q44134898Pattern of rash, diarrhea, and hepatic toxicities secondary to lapatinib and their association with age and response to neoadjuvant therapy: analysis from the NeoALTTO trial
Q46014242Regional Delivery of Chimeric Antigen Receptor-Engineered T Cells Effectively Targets HER2+ Breast Cancer Metastasis to the Brain.
Q34686390Surgical resection of brain metastases-impact on neurological outcome
Q36746835Synergistic Effect between Sphingosine-1-Phosphate and Chemotherapy Drugs against Human Brain-metastasized Breast Cancer MDA-MB-361 cells

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