PPAR Medicines and Human Disease: The ABCs of It All.

scientific article published on 7 August 2012

PPAR Medicines and Human Disease: The ABCs of It All. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1155/2012/504918
P932PMC publication ID3423947
P698PubMed publication ID22919365
P5875ResearchGate publication ID230735876

P2093author name stringAnthony J Apostoli
Christopher J B Nicol
P2860cites workPioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1/ABCG1 expressions via PPARγ/LXRα pathway: findings from in vitro and ex vivo studies.Q53224210
Multidrug resistance in locally advanced breast cancer.Q54577011
CLA-1/SR-BI Is Expressed in Atherosclerotic Lesion Macrophages and Regulated by Activators of Peroxisome Proliferator-Activated ReceptorsQ58150309
Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecanQ73088375
Bezafibrate induces multidrug-resistance P-Glycoprotein 3 expression in cultured human hepatocytes and humanized livers of chimeric miceQ80410289
[TNF-alpha induced reversal of multidrug resistance in human hepatocellular carcinoma cells]Q80772491
Reversal of drug resistance in ovarian cancer: where do we go from here?Q81351629
Restoration of PPARγ reverses lipid accumulation in alveolar macrophages of GM-CSF knockout miceQ82241424
Telmisartan exerts antiatherosclerotic effects by activating peroxisome proliferator-activated receptor-γ in macrophagesQ83809430
The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathwayQ22010685
Mutations in lipid transporter ABCA12 in harlequin ichthyosis and functional recovery by corrective gene transferQ24307584
PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDLQ24311741
PPAR and LXR activators regulate ABCA12 expression in human keratinocytesQ24317055
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell lineQ24338329
Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis.Q24531488
The role of peroxisome proliferator-activated receptors in carcinogenesis and chemopreventionQ24601222
A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transportQ24603087
ABC transporters: the power to changeQ24634548
Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in miceQ44535882
High-density lipoproteins: a new potential therapeutic target for the prevention of cardiovascular diseaseQ44788570
Reduction of intracellular cholesterol accumulation in THP-1 macrophages by a combination of rosiglitazone and atorvastatinQ44926037
Regulation of ABCA1 expression in human keratinocytes and murine epidermis.Q45947272
Levels of multidrug resistance (MDR1) P-glycoprotein expression by human breast cancer correlate with in vitro resistance to taxol and doxorubicin.Q45985449
Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liverQ46440370
Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processingQ46533975
Effects of fibrate drugs on expression of ABCA1 and HDL biogenesis in hepatocytesQ46689993
PPARalpha agonists positively and negatively regulate the expression of several nutrient/drug transporters in mouse small intestineQ46918057
Effects of combined PPARgamma and PPARalpha agonist therapy on reverse cholesterol transport in the Zucker diabetic fatty rat.Q46923577
Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alphaQ46935309
The effect of PPARalpha and PPARgamma ligands on inflammation and ABCA1 expression in cultured gallbladder epithelial cellsQ46953942
Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancerQ47969061
Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha.Q51556346
Expression of the transcription factor lung Krüppel-like factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo.Q52032014
Effects of rosiglitazone and atorvastatin on the expression of genes that control cholesterol homeostasis in differentiating monocytesQ40334975
The CD44 receptor interacts with P-glycoprotein to promote cell migration and invasion in cancerQ40390461
Molecular physiology of reverse cholesterol transportQ40526401
Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux.Q40558191
PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathwayQ40669358
Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts.Q41091588
Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiationQ41451147
PPAR-gamma: adipogenic regulator and thiazolidinedione receptorQ41755813
Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in miceQ42526889
Multidrug resistance in breast cancer: from in vitro models to clinical studiesQ42695791
PPARγ activates ABCA1 gene transcription but reduces the level of ABCA1 protein in HepG2 cellsQ42856938
Regulatory action on rosiglitazone by the U.S. Food and Drug AdministrationQ42860408
ABC transporters in cancer: more than just drug efflux pumps.Q43193922
Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: a randomized controlled trialQ43553725
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.Q43579744
Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathwaysQ43994076
Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouseQ44269265
Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytesQ24651375
Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1Q28141056
A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesisQ28199913
The human ATP-binding cassette (ABC) transporter superfamilyQ28204495
Multidrug resistance in cancer: role of ATP-dependent transportersQ28208049
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell linesQ28247169
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptorsQ28276138
Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophagesQ28283333
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferatorsQ28304744
The PPARs: from orphan receptors to drug discoveryQ28371618
Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouseQ28509638
ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteinsQ28594013
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotypeQ29615563
Targeting multidrug resistance in cancerQ29616803
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokinesQ29620217
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activationQ29620219
Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trialQ30080004
Conjugated linoleic acid isomers reduce cholesterol accumulation in acetylated LDL-induced mouse RAW264.7 macrophage-derived foam cellsQ30319415
Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4.Q30764627
Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptorQ30881181
PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathwayQ31793810
Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells.Q31856730
Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genesQ31932176
Influence of lipid lowering fibrates on P-glycoprotein activity in vitro.Q33196280
Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cellsQ33247258
Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fastingQ33293463
P-glycoprotein: from genomics to mechanism.Q34272173
Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux.Q34277079
Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999Q34360283
Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patientsQ34433361
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutantsQ34488592
Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent mannerQ34556218
Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist.Q34582444
Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes.Q34701840
Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trialQ34985342
New strategies in managing and preventing atherosclerosis: focus on HDL.Q35002306
Pleiotropic effects of glitazones: a double edge sword?Q35025858
Assessing the association of pioglitazone use and bladder cancer through drug adverse event reportingQ35043204
Medicinal Chemistry and Actions of Dual and Pan PPAR ModulatorsQ35216684
Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitroQ35753181
Inflammation in atherosclerosis and diabetes mellitusQ35813657
PPARs: therapeutic targets for metabolic diseaseQ36110177
Retinoid x receptor heterodimers in the metabolic syndromeQ36225102
PPARs in diseases: control mechanisms of inflammationQ36353852
Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoproteinQ36501176
The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosisQ36506556
Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteinsQ36525551
Pathomechanisms of harlequin ichthyosis and ABCA transporters in human diseasesQ36538928
Effect of fenofibrate therapy and ABCA1 polymorphisms on high-density lipoprotein subclasses in the Genetics of Lipid Lowering Drugs and Diet NetworkQ36687632
PPARs and molecular mechanisms of transrepressionQ36791361
A role for multidrug resistance protein 4 (MRP4; ABCC4) in human dendritic cell migrationQ36868737
The biochemistry and function of stratum corneum lipids.Q36885208
Is there a role for fibrates in the management of dyslipidemia in the metabolic syndrome?Q36918533
Role of the MRP1/ABCC1 multidrug transporter protein in cancerQ37034313
Ichthyosis update: towards a function-driven model of pathogenesis of the disorders of cornification and the role of corneocyte proteins in these disordersQ37045238
Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteinsQ37083713
Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid.Q37291393
Direct antiatherosclerotic effects of PPAR agonistsQ37365530
Troglitazone reverses the multiple drug resistance phenotype in cancer cells.Q37403238
On the mechanism for PPAR agonists to enhance ABCA1 gene expressionQ37464644
PPARs: diverse regulators in energy metabolism and metabolic diseasesQ37681306
New insights into the role of PPARsQ37903527
Mammalian multidrug-resistance proteins (MRPs).Q37941757
Atherosclerosis: current pathogenesis and therapeutic optionsQ37953777
Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.Q37977108
Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell lineQ38290528
Regulation of breast cancer resistant protein by peroxisome proliferator-activated receptor α in human brain microvessel endothelial cellsQ38328428
13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophagesQ39435368
Mycophenolic acid induces ATP-binding cassette transporter A1 (ABCA1) expression through the PPARγ-LXRα-ABCA1 pathwayQ39456852
Reversal of P-glycoprotein-mediated multidrug resistance in SGC7901/VCR cells by PPARgamma activation by troglitazoneQ39691751
Interaction of thiazolidinediones (glitazones) with the ATP-binding cassette transporters P-glycoprotein and breast cancer resistance proteinQ39795888
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P304page(s)504918
P577publication date2012-08-07
P1433published inPPAR ResearchQ15756406
P1476titlePPAR Medicines and Human Disease: The ABCs of It All.
P478volume2012

Reverse relations

cites work (P2860)
Q28540807An in-silico model of lipoprotein metabolism and kinetics for the evaluation of targets and biomarkers in the reverse cholesterol transport pathway
Q35861003Characterization of Visceral and Subcutaneous Adipose Tissue Transcriptome and Biological Pathways in Pregnant and Non-Pregnant Women: Evidence for Pregnancy-Related Regional-Specific Differences in Adipose Tissue
Q40073832Effects of germinated brown rice and its bioactive compounds on the expression of the peroxisome proliferator-activated receptor gamma gene.
Q38817895Peroxisome proliferator-activated receptors in cardiac energy metabolism and cardiovascular disease

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