Preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine

scientific article published on 7 November 2013

Preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PNTD.0002538
P932PMC publication ID3820736
P698PubMed publication ID24244774
P5875ResearchGate publication ID258639695

P50authorJorge E. OsorioQ28743695
P2093author name stringCharalambos D Partidos
Joseph D Santangelo
Shi-Hsia Hwa
Joseph N Brewoo
Yock Ann Lee
P2860cites workA mouse muscle-adapted enterovirus 71 strain with increased virulence in miceQ84195454
Oral immunization of mice using transgenic tomato fruit expressing VP1 protein from enterovirus 71Q95821973
Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71.Q39835244
Differences in perception of dysentery and enteric fever and willingness to receive vaccines among rural residents in ChinaQ40498833
Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against diseaseQ41988715
A Phase I, randomized, open-label study to evaluate the safety and immunogenicity of an enterovirus 71 vaccineQ42694361
Clinical spectrum of enterovirus 71 infection in children in southern Taiwan, with an emphasis on neurological complications.Q43523822
Protection of neonatal mice from lethal enterovirus 71 infection by maternal immunization with attenuated Salmonella enterica serovar Typhimurium expressing VP1 of enterovirus 71.Q43914758
Combined peptides of human enterovirus 71 protect against virus infection in miceQ43934303
Pyramidal and extrapyramidal involvement in experimental infection of cynomolgus monkeys with enterovirus 71.Q43981254
Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancementQ45361800
Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challengeQ45396589
Neutralizing antibody provided protection against enterovirus type 71 lethal challenge in neonatal miceQ46354156
Cross-antigenicity among EV71 strains from different genogroups isolated in Yamagata, Japan, between 1990 and 2007.Q46550828
Phylogenetic designation of enterovirus 71 genotypes and subgenotypes using complete genome sequences.Q47736273
Fulminant neurogenic pulmonary oedema with hand, foot, and mouth diseaseQ48405572
Genetic and antigenic analyses of enterovirus 71 isolates in Taiwan during 1998-2005Q80290931
Aluminium assay and evaluation of the local reaction at several time points after intramuscular administration of aluminium containing vaccines in the Cynomolgus monkeyQ81299406
DNA vaccine constructs against enterovirus 71 elicit immune response in miceQ21245503
Production of EV71 vaccine candidatesQ26866091
Identification and validation of clinical predictors for the risk of neurological involvement in children with hand, foot, and mouth disease in SarawakQ27487876
The Enterovirus 71 A-particle Forms a Gateway to Allow Genome Release: A CryoEM Study of Picornavirus UncoatingQ27677204
Scavenger receptor B2 is a cellular receptor for enterovirus 71Q28249350
Phylogenetic evidence for inter-typic recombination in the emergence of human enterovirus 71 subgenotypesQ33255718
Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998Q33824871
Neurologic complications in children with enterovirus 71 infectionQ33875092
Purification and characterization of enterovirus 71 viral particles produced from vero cells grown in a serum-free microcarrier bioreactor system.Q33908518
Display of VP1 on the surface of baculovirus and its immunogenicity against heterologous human enterovirus 71 strains in miceQ33958090
Typing of human enteroviruses by partial sequencing of VP1.Q33960048
Forecasting the economic value of an Enterovirus 71 (EV71) vaccineQ34338981
Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trialQ34347924
Challenges to licensure of enterovirus 71 vaccinesQ34406820
Comparative analysis of the immunogenicity and protective effects of inactivated EV71 vaccines in miceQ34430681
Cross-reactive neutralizing antibody responses to enterovirus 71 infections in young children: implications for vaccine developmentQ34607995
Non-clinical vaccine safety assessmentQ34612424
Adaptation of enterovirus 71 to adult interferon deficient miceQ34635242
An overview of the evolution of enterovirus 71 and its clinical and public health significanceQ34635602
A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infectionQ35702513
A non-mouse-adapted enterovirus 71 (EV71) strain exhibits neurotropism, causing neurological manifestations in a novel mouse model of EV71 infectionQ35826494
The poliovirus 135S particle is infectiousQ35870848
An attenuated strain of enterovirus 71 belonging to genotype a showed a broad spectrum of antigenicity with attenuated neurovirulence in cynomolgus monkeys.Q35948053
Immunological evaluation and comparison of different EV71 vaccine candidatesQ36248450
Virology, epidemiology, pathogenesis, and control of enterovirus 71.Q37801742
Inactivation of viral antigens for vaccine preparation with particular reference to the application of binary ethylenimineQ37951381
Safety and immunogenicity of a novel human Enterovirus 71 (EV71) vaccine: a randomized, placebo-controlled, double-blind, Phase I clinical trialQ38474516
Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: current genotyping of EV71 does not reflect their antigenicity.Q39255114
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)e2538
P577publication date2013-11-07
P1433published inPLoS Neglected Tropical DiseasesQ3359737
P1476titlePreclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine
P478volume7

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cites work (P2860)
Q92968336An inactivated enterovirus 71 vaccine is safe and immunogenic in healthy adults: A phase I, double blind, randomized, placebo-controlled, study of two dosages
Q37130763Comprehensive safety assessment of a human inactivated diploid enterovirus 71 vaccine based on a phase III clinical trial
Q38195326Development of enterovirus 71 vaccines: from the lab bench to Phase III clinical trials
Q30383172EV71 vaccine, a new tool to control outbreaks of hand, foot and mouth disease (HFMD).
Q28606867Efficacy of a Trivalent Hand, Foot, and Mouth Disease Vaccine against Enterovirus 71 and Coxsackieviruses A16 and A6 in Mice
Q37628730Epidemiologic Features of Enterovirus 71-Associated Hand-Foot-and-Mouth Disease from 2009 to 2013 in Zhejiang, China
Q38835845Epidemiological features and spatio-temporal clusters of hand-foot-mouth disease at town level in Fuyang, Anhui Province, China (2008-2013).
Q30249022Hand, foot and mouth disease (HFMD): emerging epidemiology and the need for a vaccine strategy.
Q40855930Status of research and development of vaccines for enterovirus 71.
Q42230193Surveillance of hand, foot, and mouth disease for a vaccine

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