Synthesis and biological evaluation of novel antiviral agents as protein-protein interaction inhibitors

scientific article published on 16 July 2013

Synthesis and biological evaluation of novel antiviral agents as protein-protein interaction inhibitors is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3109/14756366.2013.766609
P698PubMed publication ID23859152

P50authorLaura De LucaQ40121137
Rosaria GittoQ42716973
Zeger DebyserQ47494689
Alba ChimirriQ47494703
Frauke ChristQ75662430
P2093author name stringStefania Ferro
Francesca Morreale
P2860cites workNew 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitorsQ40121044
Emerging role of integrase inhibitors in the management of treatment-experienced patients with HIV infectionQ41434760
Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysisQ43454997
From ligand to complexes: inhibition of human immunodeficiency virus type 1 integrase by beta-diketo acid metal complexes.Q44619681
Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactorQ45586245
A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole seriesQ46640952
GBPM: GRID-based pharmacophore model: concept and application studies to protein-protein recognition.Q48453010
Insight into the fundamental interactions between LEDGF binding site inhibitors and integrase combining docking and molecular dynamics simulations.Q52632131
Identification of the LEDGF/p75 binding site in HIV-1 integraseQ24321722
Development and validation of a genetic algorithm for flexible dockingQ28236574
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75Q28250867
Novel targets for HIV therapyQ28293786
Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.Q33476232
Microwave assisted organic synthesis (MAOS) of small molecules as potential HIV-1 integrase inhibitors.Q33991491
HIV-1 integrase inhibitors: past, present, and futureQ34050694
HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigationQ34158634
Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.Q34161123
HIV-1 integrase: the next target for AIDS therapy?Q34257536
Integrase inhibitors to treat HIV/AIDS.Q34397376
A small-molecule antagonist of virion assemblyQ34489215
Allosteric inhibitor development targeting HIV-1 integraseQ35046515
HIV-1 integrase: a target for new AIDS chemotherapeuticsQ35768565
Twenty-six years of anti-HIV drug discovery: where do we stand and where do we go?Q37604356
Computational analysis of Human Immunodeficiency Virus (HIV) Type-1 reverse transcriptase crystallographic models based on significant conserved residues found in Highly Active Antiretroviral Therapy (HAART)-treated patientsQ37656453
Inhibitors of the interactions between HIV-1 IN and the cofactor LEDGF/p75.Q37867081
Inhibition of the interaction between HIV-1 integrase and its cofactor LEDGF/p75: a promising approach in anti-retroviral therapyQ37886203
4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration processQ39504985
Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitorsQ39913483
P433issue2
P921main subjectprotein-protein interactionQ896177
P304page(s)237-242
P577publication date2013-07-16
P1433published inJournal of Enzyme Inhibition and Medicinal ChemistryQ15708877
P1476titleSynthesis and biological evaluation of novel antiviral agents as protein-protein interaction inhibitors
P478volume29

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cites work (P2860)
Q35158672Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space
Q40613330Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein-protein Interaction Inhibitors
Q40314766Study of Structure-active Relationship for Inhibitors of HIV-1 Integrase LEDGF/p75 Interaction by Machine Learning Methods

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