Sustained expression of miR-26a promotes chromosomal instability and tumorigenesis through regulation of CHFR.

scientific article published on 26 January 2017

Sustained expression of miR-26a promotes chromosomal instability and tumorigenesis through regulation of CHFR. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/NAR/GKX022
P932PMC publication ID5416844
P698PubMed publication ID28126920

P50authorSilvia OttavianiQ53077137
Justin StebbingQ86918342
P2093author name stringAleksandra Dabrowska
Paul Cathcart
Leandro Castellano
Jonathan Krell
Adam E Frampton
Loredana Pellegrino
P2860cites workChfr defines a mitotic stress checkpoint that delays entry into metaphaseQ22254761
miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifsQ24292787
miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOTQ24292808
The RNA binding protein Larp1 regulates cell division, apoptosis and cell migrationQ24308702
Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesisQ24310798
MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb proteinQ24601263
miRTarBase: a database curates experimentally validated microRNA-target interactionsQ24613026
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancersQ24625794
The impact of microRNAs on protein outputQ24653549
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer modelQ24655262
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivoQ24657924
MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammalsQ24680274
Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cellsQ27345177
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targetsQ27860792
Widespread changes in protein synthesis induced by microRNAsQ27860886
miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stressQ39043647
MiR-26a enhances metastasis potential of lung cancer cells via AKT pathway by targeting PTEN.Q39299200
Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppressionQ40114418
The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancerQ40502692
14-3-3 family members act coordinately to regulate mitotic progressionQ40563137
SurvMicro: assessment of miRNA-based prognostic signatures for cancer clinical outcomes by multivariate survival analysisQ43795986
Curcumin disrupts mitotic spindle structure and induces micronucleation in MCF-7 breast cancer cellsQ44026767
The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleusQ45240522
The spindle checkpointQ56951146
Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomasQ73154777
Silencing of microRNAs in vivo with 'antagomirs'Q27860891
MicroRNAs: genomics, biogenesis, mechanism, and functionQ27861070
Chfr expression is downregulated by CpG island hypermethylation in esophageal cancerQ28206993
Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancersQ28214439
Inhibition of translational initiation by Let-7 MicroRNA in human cellsQ28265842
Genomic instability--an evolving hallmark of cancerQ28274009
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformationQ28285317
MYC stimulates EZH2 expression by repression of its negative regulator miR-26aQ28291303
Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancerQ28295895
Chfr is required for tumor suppression and Aurora A regulationQ28510913
A mechanism linking extra centrosomes to chromosomal instabilityQ29617923
14-3-3 proteins: structure, function, and regulationQ29619100
miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcriptsQ30540092
Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorshipQ33719798
14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesisQ33720143
Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cellsQ34155349
Trastuzumab produces therapeutic actions by upregulating miR-26a and miR-30b in breast cancer cellsQ34181700
Short interfering RNAs as a tool for cancer gene therapyQ34369280
Methylation of tumor suppressor genes is related with copy number aberrations in breast cancerQ34991280
The auto-ubiquitylation of E3 ubiquitin-protein ligase Chfr at G2 phase is required for accumulation of polo-like kinase 1 and mitotic entry in mammalian cellsQ35182916
Chromosome aberrations in solid tumorsQ35201471
Centrosomal amplification and spindle multipolarity in cancer cellsQ35990959
Antisense therapy for cancerQ36133133
AneuploidyQ36465788
MicroRNAs and chromosomal abnormalities in cancer cellsQ36617820
TP53 regulates miRNA association with AGO2 to remodel the miRNA-mRNA interaction networkQ36633192
Cytokinesis arrest and redistribution of actin-cytoskeleton regulatory components in cells expressing the Rho GTPase CDC42Hs.Q36823371
The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response.Q37354147
Overexpression of LARP1 predicts poor prognosis of colorectal cancer and is expected to be a potential therapeutic targetQ37447620
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue8
P304page(s)4401-4412
P577publication date2017-05-01
P1433published inNucleic Acids ResearchQ135122
P1476titleSustained expression of miR-26a promotes chromosomal instability and tumorigenesis through regulation of CHFR
P478volume45

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cites work (P2860)
Q47200415Ancient and modern: hints of a core post-transcriptional network driving chemotherapy resistance in ovarian cancer
Q64069874Circular RNA circCHFR Facilitates the Proliferation and Migration of Vascular Smooth Muscle via miR-370/FOXO1/Cyclin D1 Pathway
Q91529114HNRNPA2/B1 is upregulated in endocrine-resistant LCC9 breast cancer cells and alters the miRNA transcriptome when overexpressed in MCF-7 cells
Q48126654MiR-489 suppresses tumor growth and invasion by targeting HDAC7 in colorectal cancer.
Q47142132MicroRNA in Glioblastoma: An Overview
Q46277416Molecular genetics and cellular events of K-Ras-driven tumorigenesis.
Q91610547miRNA-26a-5p Accelerates Healing via Downregulation of PTEN in Fracture Patients with Traumatic Brain Injury

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