Metabolic and Cardiovascular Benefits and Risks of EMD386088-A 5-HT6 Receptor Partial Agonist and Dopamine Transporter Inhibitor

scientific article published on 8 February 2017

Metabolic and Cardiovascular Benefits and Risks of EMD386088-A 5-HT6 Receptor Partial Agonist and Dopamine Transporter Inhibitor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FNINS.2017.00050
P932PMC publication ID5296348
P698PubMed publication ID28228713

P50authorMagdalena KotańskaQ58658505
Magdalena Jastrzębska-WięsekQ59703080
Joanna SniecikowskaQ91350774
Marcin KolaczkowskiQ91350780
Karolina PytkaQ43191797
P2860cites workTesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: dopamine transporter occupancy as measured by PET.Q43497308
Partial agonist efficacy of EMD386088, a 5-HT6 receptor ligand, in functional in vitro assays.Q43760124
"Nonhedonic" food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effectQ43959924
Cardiovascular effects of methylphenidate in humans are associated with increases of dopamine in brain and of epinephrine in plasmaQ44317525
Pharmacological characterisation of the thermogenic effect of bupropionQ45056272
Pharmacological evaluation of the anxiolytic-like effects of EMD 386088, a partial 5-HT6 receptor agonist, in the rat elevated plus-maze and Vogel conflict tests.Q46610840
Pyrrolidin-2-one derivatives may reduce body weight in rats with diet-induced obesityQ47324338
Pica in rats is analogous to emesis: an animal model in emesis researchQ70519103
Diabetic dyslipidaemiaQ89261937
Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese ratsQ24675513
Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporterQ26829749
Dopamine signaling in food addiction: role of dopamine D2 receptorsQ27021853
Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disordersQ28260500
2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonistsQ28264695
Study of a mechanism responsible for potential antidepressant activity of EMD 386088, a 5-HT6 partial agonist in ratsQ28275114
A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced ObesityQ28550518
Brain dopamine and obesityQ32040881
Weight gain is associated with reduced striatal response to palatable foodQ34258063
Inhibition of dopamine and norepinephrine reuptake produces additive effects on energy balance in lean and obese miceQ34547482
Role of 5-HT3 receptor on food intake in fed and fasted miceQ35196080
The progression of cardiovascular risk to cardiovascular disease.Q36970153
Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factorsQ37136276
Relation of reward from food intake and anticipated food intake to obesity: a functional magnetic resonance imaging studyQ37189446
Regulation of the dopamine transporter: aspects relevant to psychostimulant drugs of abuse.Q37702373
Targeting 5-HT receptors for the treatment of obesityQ37844308
Naltrexone/bupropion: an investigational combination for weight loss and maintenance.Q37976220
Serotonin controlling feeding and satietyQ38248834
Modern obesity pharmacotherapy: weighing cardiovascular risk and benefitQ38249884
A role for 5-ht6 receptors in retention of spatial learning in the Morris water maze.Q38298172
Antidepressant-like activity of EMD 386088, a 5-HT6 receptor partial agonist, following systemic acute and chronic administration to rats.Q38298300
Dopaminergic agonists normalize elevated hypothalamic neuropeptide Y and corticotropin-releasing hormone, body weight gain, and hyperglycemia in ob/ob miceQ38316225
Therapeutic Potential of 5-HT6 Receptor Agonists.Q38534316
The 5-HT6 receptor agonist EMD 386088 produces antidepressant and anxiolytic effects in rats after intrahippocampal administration.Q42597841
P304page(s)50
P577publication date2017-02-08
P1433published inFrontiers in NeuroscienceQ2177807
P1476titleMetabolic and Cardiovascular Benefits and Risks of EMD386088-A 5-HT6 Receptor Partial Agonist and Dopamine Transporter Inhibitor
P478volume11

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cites work (P2860)
Q91814012Are the Hydantoin-1,3,5-triazine 5-HT6R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro
Q57039732Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT₆ Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo
Q47172455Idalopirdine, a selective 5-HT6 receptor antagonist, reduces food intake and body weight in a model of excessive eating.
Q91704575Social-housing and use of double-decker cages in rat telemetry studies
Q92128383The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment
Q88867837The histamine H3 receptor inverse agonist pitolisant reduces body weight in obese mice

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