Partial agonist efficacy of EMD386088, a 5-HT6 receptor ligand, in functional in vitro assays.

scientific article

Partial agonist efficacy of EMD386088, a 5-HT6 receptor ligand, in functional in vitro assays. is …
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scholarly articleQ13442814

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P356DOI10.1016/S1734-1140(13)71081-8
P698PubMed publication ID24145094

P50authorMagdalena Jastrzębska-WięsekQ59703080
Monika MarcinkowskaQ59822638
Agata SiwekQ91209754
Marcin KolaczkowskiQ91350780
Grzegorz KazekQ114331031
Anna PartykaQ58958203
Anna WesołowskaQ58958243
P2093author name stringBarbara Nawieśniak
P2860cites work5-HT6 receptors positively coupled to adenylyl cyclase in striatal neurones in cultureQ72110315
Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptorQ24310557
Characterization of [(125)I]-SB-258585 binding to human recombinant and native 5-HT(6) receptors in rat, pig and human brain tissueQ24674871
Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathwaysQ24675480
Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466Q28236198
Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cellsQ28243874
5-ht6 receptorsQ28245286
Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disordersQ28260500
A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulationQ28263452
2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonistsQ28264695
Potential role of the 5-HT6 receptor in depression and anxiety: an overview of preclinical dataQ33706897
N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonistsQ33923475
E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat.Q34111024
Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression.Q34576271
SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models.Q34577251
Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulationQ34618354
Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats.Q34673522
Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonistQ34703801
5-HT6 receptors: a novel target for cognitive enhancementQ36187762
Partial agonists, full agonists, antagonists: dilemmas of definitionQ36741987
5-HT6 receptor signal transduction second messenger systemsQ37809903
Behavioral pharmacology: potential antidepressant and anxiolytic properties.Q37844224
Neonatal serotonin (5-HT) depletion does not affect spatial learning and memory in ratsQ39608475
Procognitive 5-HT6 antagonists in the rat forced swimming test: potential therapeutic utility in mood disorders associated with Alzheimer's disease.Q46080371
Actions of novel agonists, antagonists and antipsychotic agents at recombinant rat 5-HT6 receptors: a comparative study of coupling to G alpha s.Q46568729
Acute and repeated treatment with the 5-HT7 receptor antagonist SB 269970 induces functional desensitization of 5-HT7 receptors in rat hippocampusQ48484963
P433issue4
P304page(s)998-1005
P577publication date2013-01-01
P1433published inPharmacological ReportsQ15766499
P1476titlePartial agonist efficacy of EMD386088, a 5-HT6 receptor ligand, in functional in vitro assays
P478volume65

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cites work (P2860)
Q38298300Antidepressant-like activity of EMD 386088, a 5-HT6 receptor partial agonist, following systemic acute and chronic administration to rats.
Q47587262Dorsomedial prefrontal cortex 5-HT6 receptors regulate anxiety-like behavior
Q36273778Idalopirdine - a small molecule antagonist of 5-HT6 with therapeutic potential against obesity
Q38627971Investigational drugs targeting 5-HT6 receptors for the treatment of Alzheimer's disease.
Q42323374Metabolic and Cardiovascular Benefits and Risks of EMD386088-A 5-HT6 Receptor Partial Agonist and Dopamine Transporter Inhibitor
Q39134334Serotonin 5-HT6 Receptor Antagonists in Alzheimer's Disease: Therapeutic Rationale and Current Development Status
Q28275114Study of a mechanism responsible for potential antidepressant activity of EMD 386088, a 5-HT6 partial agonist in rats
Q47996823Study on the effect of EMD386088, a 5-HT6 receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats.