EWS-FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway

scientific article published on 9 June 2016

EWS-FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/1873-3468.12243
P932PMC publication ID4988508
P698PubMed publication ID27282934

P50authorHeinrich KovarQ41462089
Raphaela SchwentnerQ86823360
P2093author name stringDietmar Fuchs
Sophie Erhardt
Javier Alonso
Michel Goiny
Maximilian O Kauer
Florian Kromp
Dave N T Aryee
Anna M Katschnig
Cornelia N Mutz
P2860cites workIdentification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah ReceptorQ24336486
Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35Q24338794
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Endotoxin-Induced Tryptophan Degradation along the Kynurenine Pathway: The Role of Indolamine 2,3-Dioxygenase and Aryl Hydrocarbon Receptor-Mediated Immunosuppressive Effects in Endotoxin Tolerance and Cancer and Its Implications for ImmunoparalysisQ26765777
Understanding the role of the kynurenine pathway in human breast cancer immunobiologyQ26773472
The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex diseaseQ26775306
Targeting the indoleamine 2,3-dioxygenase pathway in cancerQ26775471
Twenty Years on: What Do We Really Know about Ewing Sarcoma and What Is the Path Forward?Q26782649
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenaseQ28204166
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptorQ28249782
Association of the Ah receptor with the 90-kDa heat shock proteinQ28281332
Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanismQ28297392
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivityQ29547693
The STATs of cancer--new molecular targets come of ageQ29614601
2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of ToxicityQ29618527
Ovarian tumors in rats induced by chronic 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment.Q31463198
voom: Precision weights unlock linear model analysis tools for RNA-seq read countsQ33741687
Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signalingQ33792422
Ah receptor ligands and tumor promotion: survival of neoplastic cellsQ33864770
The aryl hydrocarbon receptor (AhR) inhibits vanadate-induced vascular endothelial growth factor (VEGF) production in TRAMP prostatesQ33986252
A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumorsQ34098524
The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesisQ34128053
Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus.Q34154342
Endogenous kynurenines as targets for drug discovery and developmentQ34156448
An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cellsQ34187909
Kynurenic acid inhibits colon cancer proliferation in vitro: effects on signaling pathwaysQ34208593
Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.Q34464009
Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream EffectorsQ34913785
EWS-FLI1 employs an E2F switch to drive target gene expression.Q35171620
Aryl hydrocarbon receptor ligands in cancer: friend and foe.Q35458027
The aryl hydrocarbon receptor contributes to the proliferation of human medulloblastoma cellsQ35913114
Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenaseQ35925641
Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humansQ35974760
Transcription of Interleukin-8: How Altered Regulation Can Affect Cystic Fibrosis Lung DiseaseQ36139057
Monitoring tryptophan metabolism in chronic immune activationQ36247653
Aryl hydrocarbon receptor, cell cycle regulation, toxicity, and tumorigenesisQ36279973
Aryl hydrocarbon receptor: Linking environment to immunityQ36378234
Tryptophan Nutrition and Metabolism: An OverviewQ36919700
A molecular function map of Ewing's sarcomaQ37165799
Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritisQ37550704
The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth.Q37682508
An introduction to the molecular basics of aryl hydrocarbon receptor biologyQ37792070
An expanding range of targets for kynurenine metabolites of tryptophanQ38057527
Role of aryl hydrocarbon receptor in cancer.Q38109748
bHLH-PAS proteins in cancerQ38164994
Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy.Q38243878
High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-SeqQ38322490
Dibenzo[A,L]pyrene-induced genotoxic and carcinogenic responses are dramatically suppressed in aryl hydrocarbon receptor-deficient miceQ38477476
Regulatory mechanisms, expression levels and proliferation effects of the FUS-DDIT3 fusion oncogene in liposarcomaQ38795105
Synergistic antitumor effect with indoleamine 2,3-dioxygenase inhibition and temozolomide in a murine glioma modelQ38814416
AhR and Arnt differentially regulate NF-κB signaling and chemokine responses in human bronchial epithelial cellsQ38958431
Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumorsQ38968663
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulatorsQ39513318
Overexpression of indoleamine 2,3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft modelQ39916520
EWS/FLI1 suppresses retinoblastoma protein function and senescence in Ewing's sarcoma cellsQ40013782
Cholecystokinin down-regulation by RNA interference impairs Ewing tumor growth.Q40145072
Reinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interferenceQ40224792
Regulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinoneQ40297002
Characterisation of the kynurenine pathway in skin-derived fibroblasts and keratinocytes.Q41499706
The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing SarcomaQ42530521
AhR: far more than an environmental sensorQ43207322
A constitutively active dioxin/aryl hydrocarbon receptor promotes hepatocarcinogenesis in miceQ44980767
Indoleamine-2,3-dioxygenase in an immunotherapy model for Ewing sarcoma.Q45572170
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acidQ48898368
Simultaneous measurement of serum tryptophan and kynurenine by HPLCQ61906305
Characteristics of interferon induced tryptophan metabolism in human cells in vitroQ61906378
Kynurenic acid in human saliva--does it influence oral microflora?Q79917706
Kynurenic acid synthesis and kynurenine aminotransferases expression in colon derived normal and cancer cellsQ84201033
Hexachlorobenzene induces cell proliferation, and aryl hydrocarbon receptor expression (AhR) in rat liver preneoplastic foci, and in the human hepatoma cell line HepG2. AhR is a mediator of ERK1/2 signaling, and cell cycle regulation in HCB-treatedQ85665598
P433issue14
P407language of work or nameEnglishQ1860
P304page(s)2063-2075
P577publication date2016-06-09
P1433published inFEBS LettersQ1388051
P1476titleEWS-FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway
P478volume590

Reverse relations

cites work (P2860)
Q89006309EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis
Q102210881Functional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis
Q57174958Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers
Q41866532Kynurenine aminotransferase activity of Aro8/Aro9 engage tryptophan degradation by producing kynurenic acid in Saccharomyces cerevisiae.

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