Amyloid beta precursor protein

mammalian protein found in Homo sapiens

Wikidata entity: Q423510

Wikimedia Commons category is Amyloid precursor protein



P682 biological process ... Q133500 (learning) learning
P682 biological process ... Q187640 (cell adhesion) cell adhesion
P682 biological process ... Q189814 (endocytosis) endocytosis
P682 biological process ... Q411391 (regulation of gene expression) regulation of gene expression
P682 biological process ... Q14864049 (cellular response to cAMP) cellular response to cAMP
P682 biological process ... Q14864368 (neuron projection development) neuron projection development
P682 biological process ... Q898362 (post-translational protein modification) post-translational protein modification
P682 biological process ... Q14864461 (positive regulation of DNA-binding transcription factor activity) positive regulation of DNA-binding transcription factor activity
P682 biological process ... Q14864563 (defense response to Gram-positive bacterium) defense response to Gram-positive bacterium
P682 biological process ... Q14864697 (regulation of peptidyl-tyrosine phosphorylation) regulation of peptidyl-tyrosine phosphorylation
P682 biological process ... Q14864830 (response to yeast) response to yeast
P682 biological process ... Q14864950 (positive regulation of JNK cascade) positive regulation of JNK cascade
P682 biological process ... Q14865018 (regulation of synapse structure or activity) regulation of synapse structure or activity
P682 biological process ... Q14865229 (defense response to Gram-negative bacterium) defense response to Gram-negative bacterium
P682 biological process ... Q14865299 (axo-dendritic transport) axo-dendritic transport
P682 biological process ... Q14865848 (suckling behavior) suckling behavior
P682 biological process ... Q14865850 (mRNA polyadenylation) mRNA polyadenylation
P682 biological process ... Q14865851 (cellular copper ion homeostasis) cellular copper ion homeostasis
P682 biological process ... Q14865853 (regulation of epidermal growth factor-activated receptor activity) regulation of epidermal growth factor-activated receptor activity
P682 biological process ... Q14865855 (mating behavior) mating behavior
P682 biological process ... Q14865857 (axon midline choice point recognition) axon midline choice point recognition
P682 biological process ... Q14865859 (neuron remodeling) neuron remodeling
P682 biological process ... Q14865861 (ionotropic glutamate receptor signaling pathway) ionotropic glutamate receptor signaling pathway
P682 biological process ... Q14865863 (collateral sprouting in absence of injury) collateral sprouting in absence of injury
P682 biological process ... Q14865865 (neuromuscular process controlling balance) neuromuscular process controlling balance
P682 biological process ... Q14865867 (synaptic assembly at neuromuscular junction) synaptic assembly at neuromuscular junction
P682 biological process ... Q14865868 (smooth endoplasmic reticulum calcium ion homeostasis) smooth endoplasmic reticulum calcium ion homeostasis
P682 biological process ... Q14865880 (positive regulation of G2/M transition of mitotic cell cycle) positive regulation of G2/M transition of mitotic cell cycle
P682 biological process ... Q904082 (Notch signaling pathway) Notch signaling pathway
P682 biological process ... Q7251493 (protein phosphorylation) protein phosphorylation
P682 biological process ... Q1345738 (nervous system development) nervous system development
P682 biological process ... Q2200417 (cognition) cognition
P682 biological process ... Q428253 (innate immune response) innate immune response
P682 biological process ... Q14599315 (response to oxidative stress) response to oxidative stress
P682 biological process ... Q14599399 (negative regulation of cell population proliferation) negative regulation of cell population proliferation
P682 biological process ... Q14599650 (cholesterol metabolic process) cholesterol metabolic process
P682 biological process ... Q14633893 (positive regulation of gene expression) positive regulation of gene expression
P682 biological process ... Q14633915 (negative regulation of neuron differentiation) negative regulation of neuron differentiation
P682 biological process ... Q14860559 (positive regulation of phosphorylation) positive regulation of phosphorylation
P682 biological process ... Q14861064 (negative regulation of peptidase activity) negative regulation of peptidase activity
P682 biological process ... Q14862256 (synapse organization) synapse organization
P682 biological process ... Q14862265 (cellular response to copper ion) cellular response to copper ion
P682 biological process ... Q14863387 (response to radiation) response to radiation
P682 biological process ... Q14863717 (regulation of translation) regulation of translation
P682 biological process ... Q7936605 (visual learning) visual learning
P682 biological process ... Q14330656 (axonogenesis) axonogenesis
P682 biological process ... Q14330676 (adult locomotory behavior) adult locomotory behavior
P682 biological process ... Q14330812 (forebrain development) forebrain development
P682 biological process ... Q14330983 (dendrite development) dendrite development
P682 biological process ... Q14331117 (positive regulation of long-term synaptic potentiation) positive regulation of long-term synaptic potentiation
P682 biological process ... Q21095197 (positive regulation of T cell migration) positive regulation of T cell migration
P682 biological process ... Q21095286 (amyloid fibril formation) amyloid fibril formation
P682 biological process ... Q21095464 (antibacterial humoral response) antibacterial humoral response
P682 biological process ... Q21097362 (positive regulation of microglial cell activation) positive regulation of microglial cell activation
P682 biological process ... Q21101491 (regulation of Wnt signaling pathway) regulation of Wnt signaling pathway
P682 biological process ... Q21103414 (antifungal humoral response) antifungal humoral response
P682 biological process ... Q21106240 (positive regulation of amyloid-beta formation) positive regulation of amyloid-beta formation
P682 biological process ... Q21107055 (negative regulation of long-term synaptic potentiation) negative regulation of long-term synaptic potentiation
P682 biological process ... Q21115404 (tumor necrosis factor production) tumor necrosis factor production
P682 biological process ... Q21116181 (cellular response to norepinephrine stimulus) cellular response to norepinephrine stimulus
P682 biological process ... Q22273352 (cellular response to amyloid-beta) cellular response to amyloid-beta
P682 biological process ... Q22295073 (neuron projection maintenance) neuron projection maintenance
P682 biological process ... Q22295793 (astrocyte activation involved in immune response) astrocyte activation involved in immune response
P682 biological process ... Q22303632 (modulation of excitatory postsynaptic potential) modulation of excitatory postsynaptic potential
P682 biological process ... Q27862092 (negative regulation of low-density lipoprotein receptor activity) negative regulation of low-density lipoprotein receptor activity
P682 biological process ... Q27862144 (regulation of presynapse assembly) regulation of presynapse assembly
P682 biological process ... Q29572967 (positive regulation of amyloid fibril formation) positive regulation of amyloid fibril formation
P682 biological process ... Q31382677 (positive regulation of astrocyte activation) positive regulation of astrocyte activation
P682 biological process ... Q42483425 (regulation of spontaneous synaptic transmission) regulation of spontaneous synaptic transmission
P682 biological process ... Q14645719 (locomotory behavior) locomotory behavior
P682 biological process ... Q14758909 (G protein-coupled receptor signaling pathway) G protein-coupled receptor signaling pathway
P682 biological process ... Q14758945 (positive regulation of glycolytic process) positive regulation of glycolytic process
P682 biological process ... Q14761969 (positive regulation of NF-kappaB transcription factor activity) positive regulation of NF-kappaB transcription factor activity
P682 biological process ... Q14762271 (regulation of protein binding) regulation of protein binding
P682 biological process ... Q14763019 (positive regulation of mitotic cell cycle) positive regulation of mitotic cell cycle
P682 biological process ... Q14818068 (positive regulation of transcription by RNA polymerase II) positive regulation of transcription by RNA polymerase II
P682 biological process ... Q14818077 (neuron apoptotic process) neuron apoptotic process
P682 biological process ... Q14819456 (platelet degranulation) platelet degranulation
P682 biological process ... Q14819468 (extracellular matrix organization) extracellular matrix organization
P682 biological process ... Q14873025 (cellular process or phenomenon) cellular process or phenomenon
P682 biological process ... Q14874348 (positive regulation of signaling receptor activity) positive regulation of signaling receptor activity
P682 biological process ... Q14897693 (cellular response to nerve growth factor stimulus) cellular response to nerve growth factor stimulus
P682 biological process ... Q14905322 (microglia development) microglia development
P682 biological process ... Q14905686 (positive regulation of NIK/NF-kappaB signaling) positive regulation of NIK/NF-kappaB signaling
P682 biological process ... Q14916304 (cellular response to manganese ion) cellular response to manganese ion
P682 biological process ... Q14819484 (positive regulation of peptidase activity) positive regulation of peptidase activity
P682 biological process ... Q14819846 (positive regulation of protein phosphorylation) positive regulation of protein phosphorylation
P682 biological process ... Q14819853 (learning or memory) learning or memory
P682 biological process ... Q14819859 (negative regulation of gene expression) negative regulation of gene expression
P682 biological process ... Q14820583 (regulation of multicellular organism growth) regulation of multicellular organism growth
P682 biological process ... Q14820663 (positive regulation of peptidyl-serine phosphorylation) positive regulation of peptidyl-serine phosphorylation
P682 biological process ... Q14821385 (positive regulation of peptidyl-threonine phosphorylation) positive regulation of peptidyl-threonine phosphorylation
P682 biological process ... Q14821386 (positive regulation of protein binding) positive regulation of protein binding
P682 biological process ... Q14821388 (positive regulation of ERK1 and ERK2 cascade) positive regulation of ERK1 and ERK2 cascade
P682 biological process ... Q14852023 (response to interleukin-1) response to interleukin-1
P682 biological process ... Q14859614 (negative regulation of endopeptidase activity) negative regulation of endopeptidase activity
P682 biological process ... Q14859633 (astrocyte activation) astrocyte activation
P682 biological process ... Q14859636 (regulation of long-term neuronal synaptic plasticity) regulation of long-term neuronal synaptic plasticity
P682 biological process ... Q14859852 (response to lead ion) response to lead ion
P682 biological process ... Q14331119 (regulation of NMDA receptor activity) regulation of NMDA receptor activity
P682 biological process ... Q14599311 (apoptotic process) apoptotic process
P681 cell component ... Q79899 (cytoplasm) cytoplasm
P681 cell component ... Q83181 (Golgi apparatus) Golgi apparatus
P681 cell component ... Q178999 (axon) axon
P681 cell component ... Q187181 (synapse) synapse
P681 cell component ... Q189094 (cell surface) cell surface
P681 cell component ... Q220599 (cytosol) cytosol
P681 cell component ... Q29548 (plasma membrane) plasma membrane
P681 cell component ... Q40260 (nucleus) nucleus
P681 cell component ... Q842429 (perikaryon) perikaryon
P681 cell component ... Q14864382 (presynaptic active zone) presynaptic active zone
P681 cell component ... Q14864882 (astrocyte projection) astrocyte projection
P681 cell component ... Q14864893 (Golgi-associated vesicle) Golgi-associated vesicle
P681 cell component ... Q14865837 (ciliary rootlet) ciliary rootlet
P681 cell component ... Q14865839 (spindle midzone) spindle midzone
P681 cell component ... Q902079 (dendritic spine) dendritic spine
P681 cell component ... Q903634 (extracellular exosome) extracellular exosome
P681 cell component ... Q2423067 (terminal bouton) terminal bouton
P681 cell component ... Q7880371 (smooth endoplasmic reticulum) smooth endoplasmic reticulum
P681 cell component ... Q1385443 (extracellular space) extracellular space
P681 cell component ... Q424178 (membrane raft) membrane raft
P681 cell component ... Q14633848 (endoplasmic reticulum lumen) endoplasmic reticulum lumen
P681 cell component ... Q14645596 (extracellular region) extracellular region
P681 cell component ... Q14860547 (recycling endosome) recycling endosome
P681 cell component ... Q7881690 (rough endoplasmic reticulum) rough endoplasmic reticulum
P681 cell component ... Q14327652 (integral component of membrane) integral component of membrane
P681 cell component ... Q14330632 (perinuclear region of cytoplasm) perinuclear region of cytoplasm
P681 cell component ... Q22327672 (main axon) main axon
P681 cell component ... Q22327935 (COPII-coated ER to Golgi transport vesicle) COPII-coated ER to Golgi transport vesicle
P681 cell component ... Q22328137 (growth cone filopodium) growth cone filopodium
P681 cell component ... Q22329391 (growth cone lamellipodium) growth cone lamellipodium
P681 cell component ... Q14645640 (neuron projection) neuron projection
P681 cell component ... Q14758889 (Golgi lumen) Golgi lumen
P681 cell component ... Q14758890 (endosome lumen) endosome lumen
P681 cell component ... Q14819447 (platelet alpha granule lumen) platelet alpha granule lumen
P681 cell component ... Q14873267 (cell-cell junction) cell-cell junction
P681 cell component ... Q14877465 (receptor complex) receptor complex
P681 cell component ... Q14904870 (trans-Golgi network membrane) trans-Golgi network membrane
P681 cell component ... Q14911785 (nuclear envelope lumen) nuclear envelope lumen
P681 cell component ... Q14840128 (cytoplasmic vesicle) cytoplasmic vesicle
P681 cell component ... Q14859540 (integral component of plasma membrane) integral component of plasma membrane
P681 cell component ... Q14860360 (dendritic shaft) dendritic shaft
P681 cell component ... Q14860538 (early endosome) early endosome
P681 cell component ... Q14860540 (clathrin-coated pit) clathrin-coated pit
P681 cell component ... Q14349455 (membrane) membrane
P681 cell component ... Q14349538 (apical part of cell) apical part of cell
P681 cell component ... Q14353100 (cell projection) cell projection
P681 cell component ... Q559423 (growth cone) growth cone
P681 cell component ... Q671136 (synaptic vesicle) synaptic vesicle
P681 cell component ... Q776995 (neuromuscular junction) neuromuscular junction
P681 cell component ... Q824237 (endosome) endosome
P373 Commons category String Amyloid precursor protein ???
P702 encoded by ... Q14865870 (APP) APP
P2888 exact match Url UniProt ???
P703 found in taxon ... Q15978631 (Homo sapiens) Homo sapiens
P692 Gene Atlas image CommonsMedia http://commons.wikimedia.org/wiki/Special:FilePath/PBB%20GE%20APP%20200602%20at.png ???
P527 has part(s) ... Q24720035 (Amyloidogenic glycoprotein, amyloid-beta peptide) Amyloidogenic glycoprotein, amyloid-beta peptide
P527 has part(s) ... Q24724569 (Amyloidogenic glycoprotein, heparin-binding) Amyloidogenic glycoprotein, heparin-binding
P527 has part(s) ... Q24776774 (Amyloidogenic glycoprotein, extracellular) Amyloidogenic glycoprotein, extracellular
P527 has part(s) ... Q24779127 (Amyloidogenic glycoprotein, copper-binding) Amyloidogenic glycoprotein, copper-binding
P527 has part(s) ... Q24781701 (Amyloidogenic glycoprotein, intracellular domain, conserved site) Amyloidogenic glycoprotein, intracellular domain, conserved site
P527 has part(s) ... Q24781840 (Proteinase inhibitor I2, Kunitz, conserved site) Proteinase inhibitor I2, Kunitz, conserved site
P527 has part(s) ... Q24782301 (Beta-amyloid precursor protein C-terminal) Beta-amyloid precursor protein C-terminal
P527 has part(s) ... Q24782403 (Amyloidogenic glycoprotein, extracellular domain conserved site) Amyloidogenic glycoprotein, extracellular domain conserved site
P527 has part(s) ... Q24784434 (Pancreatic trypsin inhibitor Kunitz domain) Pancreatic trypsin inhibitor Kunitz domain
P527 has part(s) ... Q24787118 (Amyloidogenic glycoprotein, E2 domain) Amyloidogenic glycoprotein, E2 domain
P31 instance of ... Q8054 (protein) protein
P680 molecular function ... Q167149 (protein binding) protein binding
P680 molecular function ... Q14865841 (acetylcholine receptor binding) acetylcholine receptor binding
P680 molecular function ... Q14865842 (transition metal ion binding) transition metal ion binding
P680 molecular function ... Q14865844 (growth factor receptor binding) growth factor receptor binding
P680 molecular function ... Q14633858 (DNA binding) DNA binding
P680 molecular function ... Q14861063 (peptidase inhibitor activity) peptidase inhibitor activity
P680 molecular function ... Q14863348 (PTB domain binding) PTB domain binding
P680 molecular function ... Q13667380 (metal ion binding) metal ion binding
P680 molecular function ... Q14762994 (identical protein binding) identical protein binding
P680 molecular function ... Q14819233 (signaling receptor binding) signaling receptor binding
P680 molecular function ... Q14819453 (heparin binding) heparin binding
P680 molecular function ... Q14819454 (peptidase activator activity) peptidase activator activity
P680 molecular function ... Q14874346 (signaling receptor activator activity) signaling receptor activator activity
P680 molecular function ... Q14859581 (serine-type endopeptidase inhibitor activity) serine-type endopeptidase inhibitor activity
P680 molecular function ... Q14599289 (enzyme binding) enzyme binding
P361 part of ... Q417667 (Beta amyloid) Beta amyloid
P361 part of ... Q24779223 (amyloid-beta precursor protein) amyloid-beta precursor protein
P361 part of ... Q24786013 (PH-like domain superfamily) PH-like domain superfamily
P361 part of ... Q41797301 (E2 domain superfamily) E2 domain superfamily
P361 part of ... Q41797561 (Amyloidogenic glycoprotein, heparin-binding domain superfamily) Amyloidogenic glycoprotein, heparin-binding domain superfamily
P361 part of ... Q41797769 (Amyloidogenic glycoprotein, copper-binding domain superfamily) Amyloidogenic glycoprotein, copper-binding domain superfamily
P361 part of ... Q41797976 (Pancreatic trypsin inhibitor Kunitz domain superfamily) Pancreatic trypsin inhibitor Kunitz domain superfamily
P361 part of ... Q41798162 (Amyloidogenic glycoprotein, amyloid-beta peptide superfamily) Amyloidogenic glycoprotein, amyloid-beta peptide superfamily
P361 part of ... Q83134800 (Amyloidogenic glycoprotein, heparin-binding domain, protein family) Amyloidogenic glycoprotein, heparin-binding domain, protein family
P361 part of ... Q83145772 (Amyloidogenic glycoprotein, extracellular domain, protein family) Amyloidogenic glycoprotein, extracellular domain, protein family
P361 part of ... Q83146695 (Amyloidogenic glycoprotein, copper-binding domain, protein family) Amyloidogenic glycoprotein, copper-binding domain, protein family
P361 part of ... Q83162777 (Beta-amyloid precursor protein C-terminal domain, protein family) Beta-amyloid precursor protein C-terminal domain, protein family
P361 part of ... Q83165141 (Pancreatic trypsin inhibitor Kunitz domain, protein family) Pancreatic trypsin inhibitor Kunitz domain, protein family
P361 part of ... Q83166224 (Amyloidogenic glycoprotein, E2 domain, protein family) Amyloidogenic glycoprotein, E2 domain, protein family
P361 part of ... Q95350723 (Proteinase inhibitor I2, Kunitz, conserved site, protein family) Proteinase inhibitor I2, Kunitz, conserved site, protein family
P361 part of ... Q95352469 (Amyloidogenic glycoprotein, intracellular domain, conserved site, protein family) Amyloidogenic glycoprotein, intracellular domain, conserved site, protein family
P361 part of ... Q95353444 (Amyloidogenic glycoprotein, copper-binding domain conserved site, protein family) Amyloidogenic glycoprotein, copper-binding domain conserved site, protein family
P129 physically interacts with ... Q15708278 (aducanumab) aducanumab

External Ids
P705Ensembl protein IDENSP00000396923
P705Ensembl protein IDENSP00000352760
P705Ensembl protein IDENSP00000387483
P705Ensembl protein IDENSP00000284981
P705Ensembl protein IDENSP00000406539
P705Ensembl protein IDENSP00000346129
P705Ensembl protein IDENSP00000398879
P705Ensembl protein IDENSP00000345463
P705Ensembl protein IDENSP00000350578
P705Ensembl protein IDENSP00000351796
P646Freebase ID/m/025s20g
P6366Microsoft Academic ID (discontinued)31705614
P6366Microsoft Academic ID (discontinued)2908769674
P10283OpenAlex IDC31705614
P638PDB structure ID2MXU
P638PDB structure ID2NAO
P638PDB structure ID2OTK
P638PDB structure ID2Y29
P638PDB structure ID2Y2A
P638PDB structure ID2Y3J
P638PDB structure ID2Y3K
P638PDB structure ID2Y3L
P638PDB structure ID3BKJ
P638PDB structure ID3GCI
P638PDB structure ID3IFL
P638PDB structure ID3IFN
P638PDB structure ID3IFO
P638PDB structure ID3IFP
P638PDB structure ID3JTI
P638PDB structure ID3MOQ
P638PDB structure ID3MXC
P638PDB structure ID3NYL
P638PDB structure ID3OW9
P638PDB structure ID3SV1
P638PDB structure ID3U0T
P638PDB structure ID3UMH
P638PDB structure ID3UMI
P638PDB structure ID3UMK
P638PDB structure ID4JFN
P638PDB structure ID4OJF
P638PDB structure ID4ONF
P638PDB structure ID4ONG
P638PDB structure ID4PQD
P638PDB structure ID4PWQ
P638PDB structure ID5KK3
P638PDB structure ID2M9S
P638PDB structure ID1BA6
P638PDB structure ID5HOW
P638PDB structure ID4NGE
P638PDB structure ID2R0W
P638PDB structure ID3OVJ
P638PDB structure ID2IPU
P638PDB structure ID3NYJ
P638PDB structure ID3KTM
P638PDB structure ID2M9R
P638PDB structure ID2G47
P638PDB structure ID5HOX
P638PDB structure ID2LMQ
P638PDB structure ID5HOY
P638PDB structure ID5BUO
P638PDB structure ID3DXD
P638PDB structure ID5CSZ
P638PDB structure ID5C67
P638PDB structure ID5AEF
P638PDB structure ID3BAE
P638PDB structure ID2WK3
P638PDB structure ID4M1C
P638PDB structure ID5AM8
P638PDB structure ID5AMB
P638PDB structure ID3JQL
P638PDB structure ID4HIX
P638PDB structure ID4XXD
P638PDB structure ID3L81
P638PDB structure ID4MDR
P638PDB structure ID1X11
P638PDB structure ID4MVI
P638PDB structure ID4MVK
P638PDB structure ID4MVL
P638PDB structure ID3L33
P638PDB structure ID3DXC
P638PDB structure ID3DXE
P638PDB structure ID3JQ5
P638PDB structure ID1ZJD
P638PDB structure ID3AYU
P638PDB structure ID1AAP
P638PDB structure ID1AMB
P638PDB structure ID1AMC
P638PDB structure ID1AML
P638PDB structure ID1BA4
P638PDB structure ID1BJB
P638PDB structure ID1BJC
P638PDB structure ID1BRC
P638PDB structure ID1CA0
P638PDB structure ID1HZ3
P638PDB structure ID1IYT
P638PDB structure ID1MWP
P638PDB structure ID1OWT
P638PDB structure ID1QCM
P638PDB structure ID1QWP
P638PDB structure ID1QXC
P638PDB structure ID1QYT
P638PDB structure ID1TAW
P638PDB structure ID1TKN
P638PDB structure ID1Z0Q
P638PDB structure ID1ZE7
P638PDB structure ID1ZE9
P638PDB structure ID2BEG
P638PDB structure ID2BP4
P638PDB structure ID2FJZ
P638PDB structure ID2FK1
P638PDB structure ID2FK2
P638PDB structure ID2FK3
P638PDB structure ID2FKL
P638PDB structure ID2FMA
P638PDB structure ID2LFM
P638PDB structure ID2LLM
P638PDB structure ID2LMN
P638PDB structure ID2LMO
P638PDB structure ID2LMP
P638PDB structure ID2LNQ
P638PDB structure ID2LOH
P638PDB structure ID2LP1
P638PDB structure ID2LZ3
P638PDB structure ID2LZ4
P638PDB structure ID2M4J
P638PDB structure ID2MGT
P638PDB structure ID2MJ1
P638PDB structure ID2MPZ
P638PDB structure ID2MVX
P637RefSeq protein IDNP_000475
P637RefSeq protein IDNP_001129488
P637RefSeq protein IDNP_001129601
P637RefSeq protein IDNP_001129602
P637RefSeq protein IDNP_001129603
P637RefSeq protein IDNP_001191230
P637RefSeq protein IDNP_001191231
P637RefSeq protein IDNP_001191232
P637RefSeq protein IDNP_958816
P637RefSeq protein IDNP_958817
P637RefSeq protein IDXP_024307843
P7260Transporter Classification Database ID1.C.50.1.2
P352UniProt protein IDP05067

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