Pathway-based discovery of genetic interactions in breast cancer

scientific article published on 28 September 2017

Pathway-based discovery of genetic interactions in breast cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PGEN.1006973
P932PMC publication ID5619706
P698PubMed publication ID28957314

P50authorWen WangQ56990584
Michael CostanzoQ64022058
Chad L MyersQ88414136
P2093author name stringCarol A Lange
Charles Boone
Zack Z Xu
P2860cites workFinding the missing heritability of complex diseasesQ22122198
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's diseaseQ22251067
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
PGC-1 coactivators: inducible regulators of energy metabolism in health and diseaseQ24541524
KEGG: Kyoto Encyclopedia of Genes and GenomesQ24548371
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsQ24550675
The NHGRI GWAS Catalog, a curated resource of SNP-trait associationsQ24568334
Genome-wide association study reveals genetic risk underlying Parkinson's diseaseQ24646654
The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML.Q54629037
Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathwaysQ55554520
Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D and Risk of Breast CancerQ56087735
Expression of peroxisome-proliferator activated receptor-gamma (PPAR?) and the PPAR? co-activator, PGC-1, in human breast cancer correlates with clinical outcomesQ61857372
Therapy-related acute lymphoblastic leukemia is more frequent than previously recognized and has a poor prognosisQ61873060
Acute Myeloid Leukemia After Adjuvant Breast Cancer Therapy in Older Women: Understanding RiskQ63365930
Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal womenQ79182457
TLR9 and the recognition of self and non-self nucleic acidsQ79405093
Reactome: a knowledgebase of biological pathwaysQ24795413
The genetic landscape of a cellQ28131628
Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1Q28207670
Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancerQ28240593
GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and PathogenicityQ28275543
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancerQ28303909
Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX miceQ28368272
The mystery of missing heritability: Genetic interactions create phantom heritabilityQ28732355
BOOST: A fast approach to detecting gene-gene interactions in genome-wide case-control studiesQ28749463
Large-scale genotyping identifies 41 new loci associated with breast cancer riskQ29416989
Integrating common and rare genetic variation in diverse human populationsQ29547220
Personal genomes: The case of the missing heritabilityQ29614582
Missing heritability and strategies for finding the underlying causes of complex diseaseQ29614586
Genome-wide association studies for common diseases and complex traitsQ29615822
Glutathione transferasesQ29616501
RUNX1 and its understudied role in breast cancerQ30424533
Hereditary breast cancer: ever more pieces to the polygenic puzzleQ33356511
RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary glandQ33555996
Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programsQ33568421
Genetic interactions affecting human gene expression identified by variance association mappingQ33597150
Systematic interpretation of genetic interactions using protein networksQ33622989
Progesterone and breast cancer.Q33687459
Familial Risk and Heritability of Cancer Among Twins in Nordic CountriesQ33874409
Toll-like receptor 9 in breast cancerQ33928402
Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia.Q33944747
Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1.Q34023796
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).Q34085748
Genome-wide association study identifies five new breast cancer susceptibility lociQ34114293
Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell deathQ34123770
Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humansQ34152058
Finding the sources of missing heritability in a yeast crossQ34325891
Extracellular protein kinase A as a cancer biomarker: its expression by tumor cells and reversal by a myristate-lacking Calpha and RIIbeta subunit overexpressionQ34979352
Detecting gene-gene interactions that underlie human diseasesQ34980492
Risk of marrow neoplasms after adjuvant breast cancer therapy: the national comprehensive cancer network experienceQ34996659
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general populationQ35089479
Putting genetic interactions in context through a global modular decompositionQ35145534
Incidence of acute myeloid leukemia after breast cancerQ35640784
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancerQ35755874
A multiethnic cohort in Hawaii and Los Angeles: baseline characteristicsQ35786223
The Nurses' Health Study: lifestyle and health among womenQ36111939
Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians.Q36227599
Ultrafast genome-wide scan for SNP-SNP interactions in common complex diseaseQ36354895
A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11.Q36435849
Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemiaQ36450186
Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.Q36670312
Genome-wide association analysis identifies three new breast cancer susceptibility lociQ36842233
Vitamin D signalling pathways in cancer: potential for anticancer therapeuticsQ36919979
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancerQ36956156
Biologic features and treatment outcome of secondary acute lymphoblastic leukemia--a review of 101 casesQ37158199
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.Q37356243
Protein kinase A activation confers resistance to trastuzumab in human breast cancer cell linesQ37455274
Polymorphisms in steroid hormone biosynthesis genes and risk of breast cancer and fibrocystic breast conditions in Chinese womenQ37467813
Searching for missing heritability: designing rare variant association studiesQ37543773
RETRACTED ARTICLE: Detection and replication of epistasis influencing transcription in humansQ37699035
The RUNX family: developmental regulators in cancerQ38319972
Human GSTA1-1 reduces c-Jun N-terminal kinase signalling and apoptosis in Caco-2 cellsQ39086596
A global genetic interaction network maps a wiring diagram of cellular functionQ39318959
Mapping of signaling networks through synthetic genetic interaction analysis by RNAiQ39580460
The increased expression of peroxisome proliferator-activated receptor-gamma1 in human breast cancer is mediated by selective promoter usageQ40525112
Negative regulation of MEKK1-induced signaling by glutathione S-transferase Mu.Q40527631
Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor gamma (PPAR gamma) ligand, 15-deoxy-delta 12,14prostaglandin J2 (15-d-PGJ2).Q40586826
Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cellsQ43006369
Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancerQ44033535
Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer riskQ44085002
Type 2 diabetes and subsequent incidence of breast cancer in the Nurses' Health StudyQ44453199
Polymorphic variation in GSTP1 modulates outcome following therapy for multiple myeloma.Q44468885
PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancerQ44557888
Association of homozygous wild-type glutathione S-transferase M1 genotype with increased breast cancer riskQ44770001
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritisQ44921278
Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk among postmenopausal womenQ45188730
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P304page(s)e1006973
P577publication date2017-09-28
P1433published inPLOS GeneticsQ1893441
P1476titlePathway-based discovery of genetic interactions in breast cancer
P478volume13

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cites work (P2860)
Q90645991Complex Haplotypes of GSTM1 Gene Deletions Harbor Signatures of a Selective Sweep in East Asian Populations
Q97088693Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens
Q57108215Elucidating the Underlying Functional Mechanisms of Breast Cancer Susceptibility Through Post-GWAS Analyses
Q59813527Epigenetic Factors and Mitochondrial Biology in Yeast: A New Paradigm for the Study of Cancer Metabolism?
Q93029325Genetic interaction networks in cancer cells
Q92555567Global Genetic Networks and the Genotype-to-Phenotype Relationship
Q64019134Integrating genetic and protein-protein interaction networks maps a functional wiring diagram of a cell
Q89187412Synthetic Lethal Networks for Precision Oncology: Promises and Pitfalls
Q99559613Systematic analysis of bypass suppression of essential genes
Q42366130Up For A Challenge (U4C): Stimulating innovation in breast cancer genetic epidemiology

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