Translocation of heme oxygenase-1 contributes to imatinib resistance in chronic myelogenous leukemia

scientific article published on 27 June 2017

Translocation of heme oxygenase-1 contributes to imatinib resistance in chronic myelogenous leukemia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.18684
P932PMC publication ID5620182
P698PubMed publication ID28978042

P2093author name stringBianca Schaefer
Soenke Behrends
P2860cites workExpression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductaseQ24296465
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)Q27639449
Inhibition of heme oxygenase-1 increases responsiveness of pancreatic cancer cells to anticancer treatmentQ46493698
Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance developmentQ46681664
Targeting of heat shock protein 32 (Hsp32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinibQ46892079
Immunochemical evidence for an association of heme oxygenase with the microsomal electron transport system.Q54005463
The binding sites on human heme oxygenase-1 for cytochrome p450 reductase and biliverdin reductaseQ28181839
The concept of synthetic lethality in the context of anticancer therapyQ28268061
Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosomeQ28287810
Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant defensesQ28394814
Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stressQ28510887
Mass spectrometric identification of lysine residues of heme oxygenase-1 that are involved in its interaction with NADPH-cytochrome P450 reductaseQ28569380
Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa stainingQ29614339
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemiaQ29615030
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplificationQ29618788
Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemiaQ29620690
Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteinsQ33797023
Heme-oxygenases during erythropoiesis in K562 and human bone marrow cellsQ33963776
Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loopQ34075619
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydrataseQ34208791
Heme oxygenase isoforms differ in their subcellular trafficking during hypoxia and are differentially modulated by cytochrome P450 reductase.Q34251131
Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas.Q34266894
Long-term treatment with imatinib results in profound mast cell deficiency in Ph+ chronic myeloid leukemiaQ35550174
Induction of heme oxygenase-1 by Na+-H+ exchanger 1 protein plays a crucial role in imatinib-resistant chronic myeloid leukemia cellsQ35608071
Molecular pathways: Fumarate hydratase-deficient kidney cancer--targeting the Warburg effect in cancerQ35659640
The development of imatinib as a therapeutic agent for chronic myeloid leukemiaQ35993288
Nuclear translocation of haeme oxygenase-1 is associated to prostate cancerQ36610787
C-Terminal membrane spanning region of human heme oxygenase-1 mediates a time-dependent complex formation with cytochrome P450 reductaseQ37462854
Targeting of heme oxygenase-1 attenuates the negative impact of Ikaros isoform 6 in adult BCR-ABL1-positive B-ALL.Q37619813
Heme oxygenase-1: emerging target of cancer therapyQ38426058
Therapeutic drug monitoring of imatinib, nilotinib, and dasatinib for patients with chronic myeloid leukemiaQ38462901
Mutations in the BCR-ABL1 Kinase Domain and Elsewhere in Chronic Myeloid LeukemiaQ38571435
Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activityQ38984568
Proteomic strategy for probing complementary lethality of kinase inhibitors against pancreatic cancer.Q39069263
Nuclear translocation of heme oxygenase-1 confers resistance to imatinib in chronic myeloid leukemia cellsQ39254490
PTEN deletion and heme oxygenase-1 overexpression cooperate in prostate cancer progression and are associated with adverse clinical outcomeQ39580327
Hemin counteracts the repression of Bcl-2 and NrF2 genes and the cell killing induced by imatinib in human Bcr-Abl(+) CML cellsQ39790926
Heme oxygenase-1 nuclear translocation regulates bortezomibinduced cytotoxicity and mediates genomic instability in myeloma cellsQ39956732
Identification of heme oxygenase-1 as a novel BCR/ABL-dependent survival factor in chronic myeloid leukemiaQ40559164
Erythropoietin promotes resistance against the Abl tyrosine kinase inhibitor imatinib (STI571) in K562 human leukemia cells.Q40613241
Imatinib induces mitochondria-dependent apoptosis of the Bcr-Abl-positive K562 cell line and its differentiation toward the erythroid lineage.Q40620201
Optimization of sorting conditions for the selection of stable, high-producing mammalian cell linesQ40924510
Degradation of heme by a soluble peptide of heme oxygenase obtained from rat liver microsomes by mild trypsinizationQ44272938
Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patientsQ44780594
P433issue40
P407language of work or nameEnglishQ1860
P921main subjectimatinibQ177094
P304page(s)67406-67421
P577publication date2017-06-27
P1433published inOncotargetQ1573155
P1476titleTranslocation of heme oxygenase-1 contributes to imatinib resistance in chronic myelogenous leukemia
P478volume8

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cites work (P2860)
Q64930299Heme Oxygenase-1 Inhibition Sensitizes Human Prostate Cancer Cells towards Glucose Deprivation and Metformin-Mediated Cell Death.
Q47101668Insights into the mechanism of isoenzyme-specific signal peptide peptidase-mediated translocation of heme oxygenase

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