The pharmacological role of histone demethylase JMJD3 inhibitor GSK-J4 on glioma cells

scientific article published on 2 August 2017

The pharmacological role of histone demethylase JMJD3 inhibitor GSK-J4 on glioma cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.19793
P932PMC publication ID5620280
P698PubMed publication ID28978140

P2093author name stringHongtao Zhang
Yongbing Xu
Junjie Yang
Xiaoqiang Guo
Wenqing Zhao
Zeyang Wang
Yitong Li
Aixia Sui
Qilu Hu
P2860cites workHistone demethylases in physiology and cancer: a tale of two enzymes, JMJD3 and UTX.Q36936241
H3K27 demethylases, at long lastQ36965110
The future therapeutic potential of histone demethylases: A critical analysis.Q37593487
Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs.Q37618835
Epigenetics in human gliomasQ38005274
Understanding high grade glioma: molecular mechanism, therapy and comprehensive managementQ38075981
Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with MetforminQ38735409
Histone demethylase JMJD3 at the intersection of cellular senescence and cancerQ38766347
GSKJ4, A Selective Jumonji H3K27 Demethylase Inhibitor, Effectively Targets Ovarian Cancer Stem CellsQ38814242
The Roles of Histone Demethylase UTX and JMJD3 (KDM6B) in Cancers: Current Progress and Future PerspectivesQ38837856
The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs.Q39486701
An epigenetic therapy for diffuse intrinsic pontine gliomas.Q48424265
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma.Q55456585
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomasQ24339074
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancersQ24605342
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage responseQ27670940
JMJD3 as an epigenetic regulator in development and diseaseQ28084146
Malignant gliomas in adultsQ29615708
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastomaQ29616862
Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemiaQ34403179
Targeting histone lysine demethylases - progress, challenges, and the futureQ34421279
Expression and significance of histone H3K27 demethylases in renal cell carcinomaQ34443684
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem gliomaQ34641903
Suppression of Aurora-A-FLJ10540 signaling axis prohibits the malignant state of head and neck cancerQ35493637
Inhibition of KDM6 activity during murine ESC differentiation induces DNA damageQ35892322
Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypesQ36303824
Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade gliomaQ36561184
Epidemiology and molecular pathology of gliomaQ36577353
UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemiaQ36661533
The histone demethylase jumonji coordinates cellular senescence including secretion of neural stem cell-attracting cytokinesQ36834235
P433issue40
P407language of work or nameEnglishQ1860
P304page(s)68591-68598
P577publication date2017-08-02
P1433published inOncotargetQ1573155
P1476titleThe pharmacological role of histone demethylase JMJD3 inhibitor GSK-J4 on glioma cells
P478volume8

Reverse relations

cites work (P2860)
Q64387216Assessment of epigenetic mechanisms and DNA double-strand break repair using laser micro-irradiation technique developed for hematological cells
Q61443106Comprehensive profiling of JMJD3 in gastric cancer and its influence on patient survival
Q58554073Epigenetic Targeting of Glioblastoma
Q96231245GSK-J4 induces cell cycle arrest and apoptosis via ER stress and the synergism between GSK-J4 and decitabine in acute myeloid leukemia KG-1a cells
Q91584664JMJD3 promotes the epithelial-mesenchymal transition and migration of glioma cells via the CXCL12/CXCR4 axis
Q89451403Small Molecule GSK-J1 Affects Differentiation of Specific Neuronal Subtypes in Developing Rat Retina
Q99419066Targeted inhibition of KDM6 histone demethylases eradicates tumor-initiating cells via enhancer reprogramming in colorectal cancer
Q93017613Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma Cells
Q92059786Therapeutically targeting head and neck squamous cell carcinoma through synergistic inhibition of LSD1 and JMJD3 by TCP and GSK-J1

Search more.