Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

scientific article

Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NM.3716
P932PMC publication ID4257862
P698PubMed publication ID25401693
P5875ResearchGate publication ID268449740

P50authorSabine MüllerQ89245124
P2093author name stringXi Huang
C David James
Nalin Gupta
Zhiguo Zhang
Pamela L Paris
Xiaoyue Chen
Haiyun Gan
Rintaro Hashizume
Dong Fang
David Solomon
Claudia Petritsch
Todd A Waldman
Noemi Andor
Robin Lerner
Vy Ngo
Maxwell W Tom
Yuichiro Ihara
P2860cites workReduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomasQ24339074
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomasQ24629777
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage responseQ27670940
Fast gapped-read alignment with Bowtie 2Q27860699
Role of histone H3 lysine 27 methylation in Polycomb-group silencingQ28131795
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and developmentQ28241669
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutationsQ29615392
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastomaQ29616862
ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip dataQ33575507
Polycomb complexes and silencing mechanisms.Q34320981
Brainstem glioma: a reviewQ34628180
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expressionQ36850449
Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomasQ36981245
Design and analysis of ChIP-seq experiments for DNA-binding proteinsQ37003887
An experimental xenograft mouse model of diffuse pontine glioma designed for therapeutic testingQ37344059
Targeting Wee1 for the treatment of pediatric high-grade gliomasQ37580495
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastomaQ38259785
Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN.Q39173934
Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatmentQ39277587
Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response.Q55470277
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectpharmacologyQ128406
Brainstem gliomaQ4955921
P304page(s)1394-1396
P577publication date2014-11-17
P1433published inNature MedicineQ1633234
P1476titlePharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
P478volume20

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